Dr.Nie’s research interest is the elucidation of the molecular mechanisms of hearing generation and loss. Her work focuses on potassium homeostasis and the generation of endocochlear potential in the mouse inner ear. During the last four years, she has cloned and characterized various potassium and chloride channels related to potassium cycling in the cochlea. She is also interested in the identification of transcriptional factors and their modulators, which control the development of auditory sensory hair cells.

Jilin University, China, B Sc. in Biochemistry 1979-1984
Institute of Microbiology, Chinese Academy of Sciences, China, M. Sc. in Genetics 1984-1987
Institute of Microbiology, Chinese Academy of Sciences, China, Ph. D in Genetics 1997-2000
University of California, Davis, Postdoctoral fellow in Medical Microbiology, Jan -July, 2001
University of California, Davis, Postdoctoral fellow in Neuroscience/Otolaryngology, 2001- 2004

Assistant Professor, Liaoning normal university, Dalian, China, 1987-1994
Associate Professor, Liaoning normal university, Dalian, China, 1995-2000
Assistant Adjunct Professor, University of California, Davis, 2004 - present

Society for Neuroscience
Association for Research in Otolaryngology
American Society for Biochemistry and Molecular Biology

Xiangmei Chen Award for outstanding achievement in teaching, 1995

2005  Liping Nie, Karen Mu, Weihong Feng, Michael Anne Gratton, and Ebenezer N Yamoah Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear. J Neuroscience; 25: 8671-9.
2005  Liping Nie, Weihong Feng, Rodney Diaz, Michael A Gratton, Karen Jo Doyle, and Ebenezer N Yamoah Functional Consequences of Polyamines Synthesis Inhibition by DFMO: Cellular Mechanisms for DFMO-mediated Ototoxicity. J. Bio. Chem., 280: 15097-15102.

2005  Beisel KW, Rocha-Sanchez SM, Morris KA, Liping Nie, Feng F, Kachar B, Yamoah EN, Fritzsch B Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss. J Neuroscience; 25: 9285-93.

2005  Wen Liu, Koichi Nonaka, Liping Nie, Jian Zhang, Steven D. Christenson, Juyun Bae, Steven G. Van Lanen, Emmanuel Zazopoulos, Chris M. Farnet, Catherine F. Yang, and Ben Shen The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases. Chemistry & Biology, 12: 1-10.

2005  Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, Xu Y, Liping Nie, Vazquez AE, Young JN, Glatter KA, Chiamvimonvat N. Differential isoform expression of small conductance Ca2+-activated K+ channels, SK1, SK2 and SK3 channels in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol., 289: H2714-23.

2004  Mathew C. Casimiro, Bjoern C. Knollmann, Ebenezer N. Yamoah, Liping Nie, Jay C. Vary Jr., Syevda G. Sirenko, Anne E. Greene, Alexander Grinberg, Sing Ping Huang, Steven N. Ebert, and Karl Pfeifer Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward Syndrome in humans. Genomics, 84: 555-64.

2004  Liping Nie, Haitao Song, Meifang Chen, Nipavan Chiamvimonvat, Kirk W. Beisel, Ebenezer N. Yamoah, and Ana E. Vázquez Cloning and Expression Of A Small Conductance Ca 2+ -Activated K + Channel From The Mouse Cochlea: Coexpression With ?9/?10 Acetylcholine Receptors. J. Neurophysiol., 91: 1536-44.

2004  Hongwei Dou, Ana E. Vazquez, Yoon Namkung, Hanqi Chu, Emma Lou Cardell, Liping Nie, Susan Parson, Hee-Sup Shin, and Ebenzer N. Yamoah Null Mutantion of ?1D Ca++ channel gene Result in Deafness but no vestibular defect in mice. JARO, 5: 215-226

2003  Yanfang Xu, Dipika Tuteja, Zhao Zhang, Jennifer Rodriguez, Liping Nie, Ana E. Vazquez, Kathryn A. Glatter, and Nipavan Chiamvimonvat Differential Expression of A Small Conductance, Calcium-Activated K+ Channel In Cardiac Atrial And Vertricular Myocytes. J. Bio. Chem., 278: 49085-49094.

2003  Haitao Song, Liping Nie, Adrian Rodriguez-Contrerus, Zu-hang Sheng, and Ebeneze N. Yamoah Functional Interaction of Auxilary Subunits and Synapticproteins with the Ca2+ Channel (Cav3.1) May Impart Hair cell-specific Ca2+ current properties. J. Neurophysiol., 89: 1143-1149.;

2003  Catherine T Tamse, Yanfang Xu, Haitao Song, Liping Nie, and Ebenezer N. Yamoah, Protein KinaseA Mediates Voltage-Dependent Facilitation of Ca2+Current in Presynaptic Hair Cell in Hermissenda Crassicornis. J. Neurophysiol., 89: 1718-1926.

2003  Goujun Wang, Liping Nie, and Huarong Tan. Cloning and characterization of sanO, a gene involved in nikkomycin biosynthesis in Streptomyces ansochromogenes. Lett Appl Microbiol., 37: 452-457.

2002  Huarong Tan, Yuqing Tian, Haihua Yang, Gang Liu, and Liping Nie A novel Streptomyces gene, samR, with different effects on differentiation of Streptomyces ansochromogenes and Streptomyces coelicolor. Arch Microbiol., 177: 274-278.