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Department of Obstetrics and Gynecology

Department of Obstetrics and Gynecology

Study of Women's Health Across the Nation IV: UC Davis site

Co-Investigator: Associate Professor Elaine Waetjen, M.D.

Co-Investigator: Professor Bill Lasley, Ph.D.

Research funding: National Institute of Health, U01 AG012554


The Study of Women’s Health Across the Nation (SWAN) is a Cooperative Agreement funded in September 1994 to establish a multi-center, multi-ethnic longitudinal study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition and to relate these changes to subsequent health status and age-related diseases during the postmenopause. SWAN originally enrolled 3302 women at 7 clinical centers and baseline visits were completed in 1996-1997. Thus, 10 years of follow-up are currently available on women in this cohort. SWAN focuses on four major areas: Cardiovascular Disease: Cardiovascular Risk Factor Changes in Women at Midlife; Symptoms and Conditions of Women in Mid-Life and Early Older Age Project; Physical Functioning and Osteoarthritis; and Bone: Determinants and Outcomes of Bone Mass in Mid-Life Women. These SWAN IV components have three overarching aims: 1) Characterize the endocrinology and symptomatology of the post-reproductive period and evaluate their relationships to earlier stages of the transition; 2) Ascertain health outcomes including cardiovascular and fracture events; and 3) Characterize the physiologic and psychosocial changes that occur with aging and link them to both the prior menopausal transition experience and subsequent health outcomes.