Clinical/Research Interests

Dr. Muizelaar, a nationally recognized expert in vascular surgery, head injury and trauma, is at the forefront of new treatments for stroke and head injury. He has been instrumental in equipping the ICU with some of the most advanced computerized-monitoring equipment available. Dr. Muizelaar's research includes clinical trials of presynaptic calcium-channel blockers for patients with severe head injuries and the use of hypothermia in the treatment of these conditions. He also is investigating new treatments for patients with cerebral aneurysms.

Dr. Muizelaar's clinical subspecialty expertise includes cerebral aneurysms, cerebral arterio-venous malformations, carotid endarterectomy, severe trauma, intensive care, cerebral blood flow and metabolism, facial pain, specific pain syndrome, spinal stenosis, and degenerative disease. His surgical expertise includes complex aneurysms and arteriovenous malformations, carotid and vertebral constructive surgery, skull-base tumors, hearing preservation in acoustic tumors, medulla oblongata and spinal DREZ lesions, peripheral nerve surgery including brachial plexus surgery, and spinal interbody fusion techniques. Dr. Muizelaar's research interests focus on the design, implementation and conduct of clinical trials in severe head injury and subarachnoid hemorrhage; monitoring cerebral blood flow, cerebral blood volume and metabolism with various techniques in patients; and metabolism and basic mechanisms and pharmacotherapy in experimental brain injury.

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Select Recent Publications:

Zwienenberg-Lee M, Hartmann, Rudisill NM, Muizelaar JP. Endovascular management of cerebral vasospasm. Neurosurgery, 2006. (In Press)

Maas AIR, Murray G, Henney H, Kassem N, LeGrand V, Mangelus M, Muizelaar JP, Stochetti N, Knoller N. Efficacy and safety of dexanabinol in severe traumatic brain injury: Results of a phase-III randomized placebo-controlled clinical study. The Lancet, Neurology, 2006. (In Press)

Van Putten HP, Bouwhuis MG, Muizelaar JP, Lyeth BG, Berman RF. Diffusion-weighted imaging of edema following traumatic brain injury in rats: Effects of secondary hypoxia. Journal of Neurotrauma, 22(8):857-872, 2005.

Hallam TM, Floyd CL, Folkerts MM, Lee LL, Gong QZ, Lyeth BG, Muizelaar JP, Berman RF. Comparison of behavioral deficits and acute neuronal degeneration in rat lateral-fluid percussion and weight-drop brain-injury models. Journal of Neurotrauma, 21(5):521-539, 2004.

Zwienenberg-Lee M, Muizelaar JP. Practical aspects in the management of patients with aneurysmal. Dutch Journal of Neurology, 104(6):362-371, 2003.

Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Dietrich WD, Ghajar J, Grady SM, Grossman RG, Hall ED, Heetderks W, Hovda DA, Jallo J, Katz RL, Knoller N, Kockanek PM, Maas AI, Majde J, Marion DW, Marmarou A, Marshall LF, McIntosh TK, Miller E, Mohberg N, Muizelaar JP, Pitts LH, et al. The Clinical Trials in Head Injury Study Group. Clinical trials in head injury. Journal of Neurotrauma, 19(5):503-557, 2002.

Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR, Muizelaar JP, Marion DW, Luerssen TG. Hypothermia on admission in patients with severe brain injury. Journal of Neurotrauma, 19(3):293-301, 2002.

Zwienenberg M, Muizelaar JP. Cerebral perfusion and blood flow in neurotrauma. Neurological Research, 23(2/3):167-174, 2001.

Zwienenberg M, Gong QZ, Berman RF, Muizelaar JP, Lyeth BG. The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury. Neurosurgery, 48(5):1119-1127, 2001.

Verweij BN, Vinas FC, Muizelaar JP. Hyper-acute measurement of intracranial pressure, jugular-venous oxygen saturation, and laser-doppler flowmetry before and during removal of traumatic acute subdural hematoma. Journal of Neurosurgery, 95:569-572, 2001.