Lin Zhang, M.D., Ph.D.
Medical Director, Deep Brain StimulationProgram
Lawrence J. Ellison Ambulatory Care Center
4860 Y St., Suite 0100
Sacramento, CA 95817
Clinical & Research Interests
As a fellowship-trained neurologist subspecializing in movement disorders, Dr. Zhang’s primary clinical and research interests are in Parkinson's disease (PD), tremor, ataxia, and other movement disorders. His particular expertise has led him to focus on the epidemiology of PD, exploring whether nutritional deficiencies in certain populations have an impact on PD. He currently serves as Chair of the Working Group on Genetic & Environmental Risk Factors for PD as part of the largest clinical research consortium in the country, the Parkinson Study Group (PSG). As a member site for PSG, the clinical trial program he leads at UC Davis has participated in many multicenter trials testing new medications for PD, several of which are now used in clinical practice.
Dr. Zhang’s other clinical and research interests focus on dystonia and related movement disorders such as facial spasm, limb spasticity, and dystonic tremor, all of which can be treated with neurotoxin injections, most commonly botox. He has participated in registry studies and double-blinded clinical trials for neurotoxin therapeutics, and his services presently offer four different types of neurotoxins to accommodate the patient's needs, symptoms, previous exposure to other toxins, and a variety of other indications.
Dr. Zhang also serves as the medical director of the Deep Brain Stimulation (DBS) program at UC Davis and he is very interested in the clinical applications of DBS. Under his direction the DBS program of UCDavis has become a referral center that offers implantation surgery weekly and clinical programming visits daily, serving the greater Sacramento area and northern California.
Beijing University School of Medicine
New Orleans, Louisiana
Cleveland Clinic Foundation
Cleveland Clinic Foundation
University of Rochester
Rochester, New York
Movement Disorders & Experimental Therapeutics
American Academy of Neurology
Movement Disorders Society
Parkinson Study Group
Select Recent Publications
Berneet Kaur, Danielle J. Harvey, Charles S. DeCarli, Lin Zhang, Marwan N. Sabbagh, John M. Olichney. (2012) Extrapyramidal signs by dementia severity in Alzheimer’s disease and dementia with Lewy bodies. Alzheimer's Disease and Associate Disorders, 2012(sept).
Lin Zhang, Laura Sperry, Kiarash Shahaie. (2012) Deep Brain Stimulation: A Less Invasive Surgical Option for Movement Disorders. AANLCP, 12(2): 636-643.
Randi J. Hagerman, Jamie Pak, Melina Ortigas, John Olichney, Robert Frysinger, Madeline Harrison, Edmund Cornman, Danuta Z. Loesch, Richard G. Bittar, Richard Peppard, Lin Zhang*, Kiarash Shahlaie. (2012) "Case series: Deep Brain Stimulation in Patients with FXTAS." Journal of Brain Disorders and Research, 1(2): open access.
E. Disbrow; K. Russo; C.I. Higginson.; E. W. Yund; M. I Ventura, M.A.; L. Zhang; N. Malhado-Chang; D. L. Woods; K. Sigvardt. (2012) Efficacy of Tailored Computer-Based Neurorehabilitation for Improvement of Movement Initiation in Parkinson's Disease. Brain Research, 1452(May 3): 151-64.
Hamlin A, Liu Y, Nguyen DV, Tassone F, Zhang L, Hagerman RJ. (2011) Sleep apnea in fragile X premutation carriers with and without FXTAS. American Journal of Medical Genetics, 156(8): 923-928.
Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, Decarli C, Hagerman PJ, Hagerman RJ. (2010) Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Am J Med Genet B Neuropsychiatr Genet., 153B(3): 775-85.
Zhang L, Coffey S, Lua LL, Greco CM, Schafer JA, Brunberg J, Borodyanskaya M, Agius MA, Apperson M, Leehey M, Tartaglia N, Tassone F, Hagerman PJ, Hagerman RJ. (2009) FMR1 premutation in females diagnosed with multiple sclerosis. J Neurol Neurosurg Psychiatry, 80(7): 812-4.
Lua LL and Zhang L. (2009) Development of parkinsonism following exposure to Aripiprazole: two case reports. J Med Case Reports, 3: 6448.
Hagerman RJ, Hall DA, Coffey S, Leehey M, Bourgeois J, Gould J, Zhang L, Seritan A, Berry-Kravis E, Olichney J, Miller JW, Fong AL, Carpenter R, Bodine C, Gane LW, Rainin E, Hagerman H, Hagerman PJ. (2008) Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems. Clin Interv Aging, 3(2): 215-262.
Leehey MA, Berry-Kravis E, Goetz CG, Zhang L, Hall DA, Li L, Rice CD, Lara R, Cogswell J, Reynolds A, Gane L, Jacquemont S, Tassone F, Grigsby J, Hagerman RJ, Hagerman PJ. (2008) FMR1 CGG repeat length predicts motor dysfunction in premutation carriers. Neurology, 70(16): 1397-1402.