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Department of Neurology

Department of Neurology

Faculty | Professors

Frank Sharp, M.D.

Frank Sharp, M.D.

Professor
Specialty: Neurology

UC Davis MIND Institute
2825 50th Street
Sacramento, CA  95817
(916) 703-0258
 

Clinical & Research Interests

Frank Sharp’s research focuses on molecular neurobiology, genomics, neural cell injury and cell death and the blood genomics of neurological disease. Prior to his appointment at UC Davis, Dr. Sharp had a distinguished clinical and research career at UC San Diego, UC San Francisco and the University of Cincinnati, making groundbreaking contributions to new fields of study and new insights into brain function and disease. Among these contributions were:

  • First laboratory to show proof of principle for using blood genomics to detect pathological events in the animal and human brain.
  • Paved the way for performing PET and fMRI studies in humans.
  • First to demonstrate that a transcription factor can be used to map active neurons.

Dr. Sharp is currently on the editorial boards of several journals, has been a standing member of the AHA Brain grant review committee, and is a permanent member of the NINDS NSDA review committee.

Education

UC San Diego
La Jolla, California
M.D. 1972

 

UC Davis
Davis, California
B.S. 1968

Internship

Duke University Hospitals
Durham, North Carolina
1973

Residency

University of California, San Francisco
San Francisco, California
1979
Neurology

Fellowships

National Institute of Mental Health
Bethesda, Maryland
1976

Board Certifications

American Board of Neurology, 1981

Professional Memberships

Society for Cerebral Blood Flow and Metabolism
Society for Neurochemistry
Society for Neuroscience

Select Recent Publications

Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR (2008) Gene expression changes in children with autism. Genomics. 2008 Jan;91(1):22-29

 

Sharp FR, Liu DZ, Zhan X, Ander BP. Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin and Src. Acta Neurochir Suppl. 2008, 105: 43-46.

 

Liu DZ, Cheng XY, Ander BP, Xu H, Davis RR, Gregg JP, Sharp FR.  Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol Dis. 2008 May;30(2):201-11

 

Lu A, Clark JF, Broderick JP, Pyne-Geithman GJ, Wagner KR, Ran R, Khatri P, Tomsick T, Sharp FR.  Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol. 2008 Apr;210(2):549-59.

 

Zhan X, Kim C, Sharp FR. Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res. 2008 Oct 9;1234:183-97.

 

Xu H, Tang Y, Liu DZ, Ran R, Ander BP, Apperson M, Liu XS, Khoury JC, Gregg JP, Pancioli A, Jauch EC, Wagner KR, Verro P, Broderick JP, Sharp FR (2008).  Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab. 2008 Jul;28(7):1320-1328

 

Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR (2008) Gene expression changes in children with autism. Genomics. 2008 Jan;91(1):22-29

 

Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun. 2009 Jan;23(1):124-33.