Da Zhi Liu, Ph.D.
Associate Adjunct Professor
Med Neuroscience Building
1515 Newton Court, Rm 510D
Davis, CA 95618
Dr. Liu’s research leverages the technologies and knowledge currently used in cancer research, such as oncogene inhibition (e.g. Src) or tumor suppressor elevation (e.g. miR-122), to develop new approaches for treatment of neurological diseases, including ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and vascular cognitive impairment. Liu and colleagues developed the novel concept of “aberrant cell cycle diseases” that reveals the two different types of diseases − neurological diseases and cancers − are sharing the same mechanism: aberrant cell cycle re-entry. This is because aberrant cell cycle re-entry is related not only to tumor growth in cancers, but also to neuronal death in neurological diseases. This concept provides theoretical framework for Liu’s current research using cancer elements to study neurological diseases, and paves the way to explore neural regulation in cancers.
Shanghai Institute of Materia Medica, China
PhD., Neuro-Pharmacology, 2005
University of California, Davis,
Post doc, Neuroscience, 2006-2010
Society for Neuroscience
American Heart Association
Society for Cerebral Blood Flow and Metabolism
Liu DZ, Ander BP. Cell Cycle Inhibition without Disruption of Neurogenesis is a Strategy for Treatment of Aberrant Cell Cycle Diseases: an Update.ScientificWorldJournal. 2012; 2012:491737. PMID: 22547985. Review.
Liu DZ,, Ander BP, Tian Y, Stamova B, Jickling G, Davis RR, Sharp FR. Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells. Gene, 2012; 495:120-127. PMID: 22244746
Liu DZ. Mutations in Tumor Suppressor Genes: Links between Cancers and Autism Spectrum Disorders? Journal of Cytology & Histology. 2013; 5:e109. Editorial
Liu DZ. Aberrant cell cycle re-entry: Links between Cancers and Alzheimer’s disease. JSM Alzheimer’s Disease and Related Dementia. 2014; 1(2):1006. Editorial
Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One. 2014 Jul 18;9(7):e102550. PMID: 25036109
Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B, Liu D. microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted GeneTargets. PLos One. 2014 Jun 9;9(6):e99283. PMID: 24911610
Zhan X, Jickling GC, Ander BP, Liu D, Stamova B, Cox C, Jin LW, DeCarli C, Sharp FR. Myelin injury and degraded myelin vesicles in Alzheimer's disease. Curr Alzheimer Res. 2014 Mar;11(3):232-8. PMID: 24484278
Liu DZ, Sharp FR, Van KC, Ander BP, Ghiasvand R, Stamova B, Zhan X, Jickling GC, Lyeth BG. Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury. J Neurotrauma. 2014 Jul 15;31(14):1268-76. PMID: 24428562
Liu DZ, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B, Sharp FR. Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2016;36(8):1374-83. PMID:26661204