Robert H. Fairclough, Ph.D.
Center for Neuroscience
School of Medicine
1515 Newton Court, Room 510
Davis, CA 95618
Clinical & Research Interests
Robert Fairclough's lab studies the structure and function of nicotinic acetylcholine receptors. He use anti-AChR monoclonal antibodies; fluorescence spectroscopy; electron microscopic imaging; anomalous X-ray scattering; site specific mutations of AChR expressed in oocytes followed by observing the acetylcholine induced currents; AChR Tb(III) binding studies; and any other trick we can employ to squeeze insights about the operation of this ligand gated ion channel from mother nature. He is also exploring new molecular therapies for treating both autoimmune MG and slow channel congenital MG.
New York, New York
New Haven, Connecticut
Select Recent Publications
Agius MA, Richman DP, Fairclough RH, and Maselli RA, (Eds.) Myasthenia Gravis and Related Disorders: Molecular Basis for Disease of the Neuromuscular Junction. Ann. NY. Acad. Sci. 998.
Agius M, Richman DP, Fairclough RH, Aarlie J, Gilhus NE, and Romi F. Three Forms of Immune Myasthenia. Ann. NY. Acad. Sci. 998: 453-456.
Fairclough RH, Agius MA, Gudipati E, Silvian L, Hamaoka B, Beltzner CC, Lin MY, Chuang AR and Richman DP. Agonist-Induced Transitions of the Acetylcholine Receptor. Ann. NY. Acad. Sci. 998:101-113.
Fairclough RH, Gudipati E, Lin MY, Twaddle GM, Richman DP, Burkwall DA and Josephs R. A role for a (187-199) in the conversion of agonist binding energy to the opening of the ACh receptor ion channel. Ann. NY Acad. Sci. 841: 87-92, 1998.
Gudipati E, Silvian LJ, Katta V and Fairclough RH. Distance between a-cys 192 of the acetylcholine receptor and rhodamine labeled -bungarotoxin complexed to the receptor.Ann. NY Acad. Sci. 841: 104-107, 1998.
Agius MA, Twaddle GM and Fairclough RH. Epitope spreading in experimental autoimmune myasthenia gravis. Ann. NY Acad. Sci. 841:365-367, 1998.
Agius MA, Maselli RA, Zhu S, Fairclough RH, Lin MY and Ellis W. Rhodamine-labeled alpha bungarotoxin allows visualization of endplates in congenital endplate acetylcholinesterase deficiency (CEAD). Ann. NY Acad. Sci. 841:207-209, 1998.
Agius MA, Zhu S, Lee E-K, Aarli JA, Kirvan C, Fairclough RH and Maselli R. Antibodies to AChR, synapse-organizing proteins, titin, and other muscle proteins in Morvan's fibrillary chorea. Ann. NY Acad. Sci. 841: 522-524, 1998.
Agius MA, Zhu S and Fairclough RH. Anti-rapsyn antibodies in chronic procainamide-associated myopathy (CPAM). Ann. NY Acad. Sci. 841: 527-529, 1998.
Agius MA, Zhu S, Kirvan CA, Schafer A, Lin MY, Fairclough RH, Oger JJ-F, Aziz T and Aarli JA. Rapsyn antibodies in myasthenia gravis. Ann. NY Acad. Sci. 841: 516-521, 1998.