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Department of Neurology

Department of Neurology

Faculty | Professors


Molecular physiology 



Tsung-Yu Chen, M.D., Ph.D.

Tsung-Yu Chen, M.D., Ph.D.

Specialty: Neurology

Center for Neuroscience
1544 Newton Court
Davis, CA  95618


Other Languages



National Yang-Ming Medical School
Taipei Chinese
M.D. 1986

Professional Memberships

Biophysical Society
Society for General Physiologists

Select Recent Publications

Chen T.-Y. (2005) Structure and function of ClC channels. Ann. Rev. Physiol. 67: 809-839.


Li Y, Yu W.-P., Lin C.-W. and Chen T.-Y. (2005) Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophys. J. 88: 3936-3945.


Chen M.-F. and Chen T.-Y. (2003) Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channel. J. Gen. Physiol. 122: 133-145.


Lin C.-W. and Chen T.-Y. (2003) Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J. Gen. Physiol. 122: 147-159.


Chen T.-Y., Chen M.-F. and Lin C.-W. (2003) Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. J. Gen. Physiol. 122: 641-651.


Chen T.-Y. (2003) Coupling gating with ion permeation in ClC chloride channels. Science STKE. 2003: pe23.


Chen, M.-F. and Chen., T.-Y. (2001) Different fast-gate regulation by external Cl- and H+ of the muscle-type ClC chloride channels. J. Gen Physiol. 118: 23-32.


Lin, C.-W. and Chen, T.-Y. (2000) Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J. Gen. Physiol. 116: 535-546.


Lin, Y.-W., Lin, C.-W., and Chen, T.-Y. (1999) Elimination of the slow gating of ClC-0 chloride channel by a point mutation. J. Gen. Physiol. 114: 1-12.


Chen, T.-Y. (1998) Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating. J. Gen. Physiol. 112: 715-726.