Jay V. Solnick
Associate Professor

email: jvsolnick@ucdavis.edu

Specialty: Infectious Diseases

Undergraduate Education:

University of California, San Diego

La Jolla, California

B.A. 1971

Other School:

University of North Carolina

Chapel Hill, North Carolina

Ph.D. 1977

Residencies:

Stanford University

Palo Alto, California 1986-89

Board Certifications:

American Board of Internal Medicine,

Infectious Disease, 1992

Professional Memberships:

* American Society of Microbiology

* Infectious Diseases Society of America

Fellowships: Stanford University

Worldwide, infectious diseases are the most common cause of illness and death. Unfortunately, the same is often true of underserved populations in the United States. Many of these infections, are treatable or preventable by vaccination or change in lifestyle. Because of this, the practice of infectious diseases gives me the opportunity to really make a difference. My approach to patient care is to blend a thorough evaluation of each individual patient with an understanding of the larger epidemiological and microbiological issues at hand. I make a sincere effort to treat each patient as I would wish to be treated. At UC Davis, we have the resources and the most up-to-date medical research to offer compassionate care with a solid foundation in medical science.

Solnick specializes in treating infectious diseases, especially Helicobacter pylori and enteric infectious diseases. He is evaluating a stool antigen test for detection of Helicobacter pylori in humans. Solnick's research interests also include studying the gastric pathogen, Helicobacter, and developing a rhesus monkey model of H. pylori infection at the California Regional Primate Research Center. Other projects involve identifying and characterizing regulatory genes, characterizing urease mutants, and investigating growth phase regulation.

Selected Publications: Nguyen, H.H. and Solnick, J.V. Acute infection with Hepatitis C Virus can cause dilated cardiomyopathy. Infect Dis Clin Practice, 2003, in press.

Dandekar, S., Reay, E., Taylor, J.M., and Solnick, J.V. Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques. Digest Dis Sci, 2003, in press.

Solnick, J.V. Clinical significance of Helicobacter species other than H. pylori. Clin Infec Dis, 2003, 36: 349-354.

Fernandez, K.R., Hansen, L.M., Vandamme, P., Beaman, B.L., and Solnick, J.V. Captive rhesus monkeys (Macaca mulatta) are commonly infected with Helicobacter cinaedi. J Clin Microbiol, 2002, 40: 1908-12.

Solnick, J.V., Hansen, L.M., Canfield, D.R. and Parsonnet, J. Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in the rhesus monkey (Macaca mulatta). Infection and Immunity, 2001, 69: 6887-6892.

Solnick, J.V., Hansen, L.M. and Canfield, D.R. The [14C]-urea breath test is not sensitive for detection of acute Helicobacter pylori infection in rhesus monkeys (Macaca mulatta). Digestive Diseases and Sciences, 2002, 47: 298-303.

Hansen, L.M. and Solnick, J.V. Selection for urease activity during Helicobacter pylori infection of rhesus macaques (Macaca mulatta). Infect Immun, 2001, 69:3519-22.

Solnick, J.V. and Schauer, D.B. Emergence of the Helicobacter Genus in the Pathogenesis of gastric and enterohepatic diseases, Clinical Microbiology Reviews, 2001, 14: 59-97.

Solnick, J.V., Canfield, D.R., Hansen, L.M., and Torabian, S.Z. Immunization with recombinant Helicobacter pylori urease in specific pathogen free rhesus monkeys (Macaca mulatta), Infection and Immunity, 2000, 68: 2560-65.

Mattapallil, J.J., Dandekar, S., Canfield, D.R., and Solnick, J.V. A predominant Th-1 type of immune response is induced early during acute Helicobacter pylori infection in rhesus macaques, Gastroenterology, 2000, 118: 307-15.

Tanaka, A., Prindiville, TP, Gish, R., Solnick, JV, Coppel, RL, Keeffe, EB, Ansari, A., Gershwin, ME. Are infectious agents involved in primary biliary cirrhosis: A PCR approach. Journal of Hepatology, 1999, 31:664-671.

Prier, R. and Solnick, J. V. The reemergence of water and food-borne infectious diseases. Postgraduate Medicine, 2000, 107: 245-252.

Norris, C.R., Marks, S.L., Eaton, K.A., Torabian S. Z., Munn, R.J., Solnick , J.V. The normal cat stomach is colonized with an uncultivated bacterium resembling Helicobacter felis that is associated with minimal gastritis. Journal of Clinical Microbiology, 1999, 37: 189-194.

Solnick, J.V., Canfield, D.R., Yang, S., and Parsonnet, J. The rhesus monkey model (Macaca mulatta) model of Helicobacter pylori: Noninvasive detection and derivation of specific pathogen free monkeys. Laboratory Animal Science, 1999, 49: 197-201.

Solnick, JV. Editorial: Antibiotic resistance in Helicobacter pylori. Clinical Infectious Diseases, 1998, 27: 90-92.

Foley, J., Solnick, J.V., Lapointe, J.-M., Jang, S. and Pedersen, N. Severe diarrhea associated with a novel enteric Helicobacter species in a kitten. Journal of Clinical Microbiology, 1998, 36, 908-912.

Solnick, JV, Hansen, LM, Syvanen, M. The major sigma factor (RpoD) from Helicobacter pylori and other gram negative bacteria show an enhanced rate of divergence. Journal of Bacteriology, 1997, 179: 6196-6200.

Balatbat, AB and Solnick, JV. Locally acquired Echinococcus granulosus in California. Infectious Diseases in Clinical Practice, 1997, 6: 616-618.

Solnick JV, Josenhans C, Tompkins LS, and Labigne, A. Construction and charcterization of an isogenic urease-negative mutant of Helicobacter mustelae, Infection and Immunity, 1995, 63: 3718-3721.

Andrutis, KA, Fox JG, Marini RP, Murphy JC, Yan L, Schauer DB, Solnick, JV. Inability of a urease-negative isogenic mutant of Helicobacter mustelae to colonize the ferret, Infection and Immunity, 1995, 63: 3722-3725.