CoresInvestigators
Barbara L. Shacklett
Assistant Professor
Department of Medical Microbiology and Immunology
email: blshacklett@ucdavis.edu
Specialty: Mucosal Immunology, Virology
Current Projects:
Undergraduate Education: BS, Rutgers University, 1985
Other School: PhD, Microbiology, University of California, Davis, 1994
Fellowships:
Professional Memberships:
Selected Publications:
Shacklett, B.L. (2002), Beyond 51Cr release: New methods for analyzing HIV-specific T-cell responses in peripheral blood and mucosal tissues. Clinical and Experimental Immunology 130:172-182.
Shacklett, B.L., Wilkens, D.T., Cox, C.A., Shaw, K.E.S., Adamson, L.A., Gardner, M.B., Sonigo, P. and Luciw, P.A. (2002), Live, Attenuated SIVmacM4, with Point Mutations in the Env-TM Intracytoplasmic Domain, Provides Partial Protection from Pathogenic SIVmac251. Journal of Virology 76:11365-11378.
Shacklett, B.L., Cox, C.A., Sandberg, J.K., Jacobson, M.A., Stollman, N.H. and Nixon, D.F. (2003), Trafficking of HIV-1-specific CD8+ T-cells to gut-associated lymphoid tissue (GALT) during chronic infection. Journal of Virology 77:5621-5631.
Shacklett, B.L., Yang, O., Hausner, M.A., Elliott, J., Hultin, L., Price, C., Fuerst, M., Matud, J., Hultin, P., Cox, C., Ibarrondo, J., Wong, J., Nixon, D.F., Anton, P., and Jamieson, B.D. (2003), Optimization of methods to assess human mucosal immune responses to HIV vaccination and infection. Journal of Immunological Methods 279:17-31.
Karlsson, R.K., Nixon, D.F. and Shacklett, B.L. (2003) Poorly soluble peptides can mimic authentic ELISPOT responses. (Research Letter) Journal of Immunological Methods, in press.
Shacklett, B.L., Cox, C.A., Wilkens, D.T., Karlsson, R.K., Nilsson, A., Nixon, D.F., and Price, R.W. (2004), Increased adhesion molecule and chemokine receptor expression on CD8+ T-cells trafficking to cerebrospinal fluid in HIV infection. Journal of Infectious Diseases, in press.
Shacklett, B.L., Cox, C.A., Quigley, M., Kreis, C., Stollman, N.H., Jacobson, M.A., Andersson, J., Sandberg, J.K., and Nixon, D.F. (2003), Abundant granzyme A, but not perforin, in cytolytic granules of CD8+ T-cells in gut-associated lymphoid tissue (GALT): Implications for immune control of HIV-1 infection. Submitted.