Richard M. Donovan
Research Scientist III

email: rdonovan@dhs.ca.gov

Specialty: Infectious Diseases

Undergraduate Education: University of Colorado, B.A., 1974

Graduate Education: University of Arizona, M.S., 1977, Ph.D., 1981

Professional Memberships: American Society for Microbiology, International AIDS Society, American Association for the Advancement of Science

Postdoctoral Fellowships: University of California, 1983

My major research focus has been on mechanisms of HIV pathogenesis, surrogate markers, and evaluation of antiretroviral therapy. I also have a clinical laboratory background in HIV isolation, antigen assay, serology, viral load monitoring using PCR, RT-PCR, and bDNA, in situ hybridization, HIV genotyping and phenotyping.

I am currently working on: genotypic analysis of HIV in several completed and ongoing AIDS vaccine trials; a comparative evaluation of cellular activation in HIV-infected cohorts; and the assessment of mutations associated with drug resistance and clinical outcome in HIV-infected patients.

Selected Publications: Donovan RM, Cohen SH, Peterson WR, Bolton V, Carlson JR, Jordan GW, Goldstein E, and Bush CE. In situ detection of Human Immunodeficiency Virus (HIV) nucleic acid using nonradioactive DNA probes and computerized image analysis. Journal of Histochemistry and Cytochemistry 1988;36:1573-1577.

Donovan RM, Dickover RE, Goldstein E, Dandekar S, and Carlson JR. HIV-1 proviral copy number in blood mononuclear cells from AIDS patients. Journal of Acquired Immune Deficiency Syndromes 1991; 4: 766-769.

Donovan RM, Dickover RE, Cohen SH, Bolton V, Carlson JR, Huth RG, Guozhen Liu, and Goldstein E. Decreases in unintegrated HIV DNA are associated with antiretroviral therapy in AIDS patients. Journal of Acquired Immune Deficiency Syndromes 1992;5:31-36.

Donovan RM, Bush CE, Smereck SM, Baxa DM, Markowitz NP, and Saravolatz LD. Rapid decrease In unintegrated HIV DNA after the initiation of ZDV therapy. Journal of Infectious Diseases 1994;170:202-5.

Donovan RM, Bush CE, Markowitz NP, Baxa DM, and Saravolatz LD. Changes in virus load markers during AIDS-associated opportunistic diseases in Human Immunodeficiency Virus-infected persons. Journal of Infectious Diseases 1996;174: 401-403.

Donovan RM, Moore E, Bush CE, Markowitz NP, and Saravolatz LD. Changes in plasma HIV RNA levels and CD4 cell counts after vaccination of pediatric patients. AIDS 1997; 1054-1056.

Donovan RM. Retroviridae. In Review of Veterinary Microbiology, Biberstein EL, and Zee YC, eds. Blackwell Scientific Publications, Boston. 1999.