John J. Donnelly
Senior Director
Department of Immunology & Infectious Diseases
Chiron Vaccines
Chiron Corporation

email: John_Donnelly@chiron.com

Specialty: Vaccine Research and Development

Current Projects: Vaccines against HIV amd Neisseria meningitidis groups A, B, C, W, Y, active immunization strategies for cancer therapy

Undergraduate Education: University of Pennsylvania, 1971-1975, Biology, B.A.

Other School: University of Pennsylvania, 1975-1979, Immunology, Ph.D.; US Army War College 2000-2002, Strategic studies, M.S.

Professional Memberships: American Association of Blood Banks, American Association of Immunologists, Association for Research in Vision and Ophthalmology, British Society for Immunology, New York Academy of Sciences, Royal Society for Tropical Medicine and Hygiene

Fellowships:

John Hopkins University
Baltimore, Maryland
Department of Ophthalmology
1982, Postdoctoral Research Fellow

University of Cambridge
Cambridge, England
Department of Clinical Veterinary Medicine
1980-81, Postdoctoral Research Fellow

Selected Publications: Ulmer, J.B., DeWitt, C.M., Chastain, M., Friedman, A., Donnelly, J.J., McClements, W.L., Caulfield, M.J., Bohannon, K.E., Volkin, D.B., Evans, R.K.: Enhancement of DNA Vaccine Potency Using Conventional Aluminum Adjuvants. Vaccine, 18:18-28, 2000.

McNeely, T.B., Liu, X., Bringman, T., Donnelly, J.J.: Effect of individual conjugate dose on immunogenicity of multivalent pneumococcal polysaccharide-N. meningitidis outer membrane protein complex conjugate vaccine. Vaccine, 18:2808-16, 2000.

Dupuis, M., Denis-Mize K., Woo C., Goldbeck, C., Selby, M.J., Chen, M., Otten G.R., Ulmer, J.B., Donnelly, J.J., Ott, G., and McDonald, D.M.: Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J. Immunol. 165:2850-2858, 2000.

Denis-Mize, K.S., Dupuis M., MacKichan, M.L., Singh, M., Doe, B., O'Hagan, D., Ulmer, J.B., Donnelly, J.J., McDonald, D.M., and Ott, G.: Plasmid DNA adsorbed onto caitonic micropraticles mediates target gene expression and antigen presentation by dendritic cells. Gene Therapy, in press.

Ugozzoli, M., Santos, G., Donnelly, J.J., and O'Hagan, D: The potency of a genetically toxoided mucosal adjuvant derived from the heat labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of pre-existing immunity to the adjuvant. J. Infec. Dis. 183:351-4, 2001.

Singh M., Ott G, Kazzaz J, Ugozzoli M, Briones M, Donnelly J, O'Hagan DT. Cationic microparticles are an effective delivery system for immune stimulatory CpG DNA. Pharm. Res., 18:1476-9, 2001.

Santos GF, Deck RR, Donnelly JJ, Blackwelder W, and Granoff DM. Importance of complement source when measuring meningococcal bactericidal titers as a surrogate of protective efficacy. Clin Diagn. Lab Immunol. 8:616-23, 2001.

Srivastava, I.K., L. Stamatatos, A. Fong, H. Legg, E. Kan, S. Coates, L. Leung, M. Wininger, A.R. Tipton, J. Donnelly, J.B. Ulmer, and S.W. Barnett. Purification and characterization of oligomeric glycoprotein from a primary R5 subtype B human immunodeficiency virus for vaccine applications. J. Virology. 76:2835-47, 2002.

Anderson E.L., Frey S.L., Geldmacher K., Radley D., Lee A., Donnelly, J.J., Mendelman, P.M., Dargan J.M., Kaplan K.M. Safety, tolerability and immunogenicity of low dose Haemophilus influenzae type b conjugated to the outer membrane protein complex of Neisseria meningitidis group B. Ped. Inf. Dis. J. 21:350-2, 2002.

O'Hagan DT, Singh M, Kazzaz J, Ugozzoli M, Briones M, Donnelly J, Ott G: Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen. Vaccine. 20: 3389-98, 2002.