David Michael Asmuth
Assistant Professor
Division of Infectious Diseases
Department of Internal Medicine

email: dasmuth@ucdavis.edu

Specialty:

• HIV/AIDS Pathogenesis and Treatment
• HIV/HCV Co-infection Pathogenesis and Treatment
• Pathogen-specific Cell Mediated Immune Responses

Undergraduate Education:

• University of Notre Dame
  Notre Dame, Indiana
  B.A., 1977

Medical Education:

• Northwestern University Medical School
  Chicago, Illinois
  M.D., 1985

Internships:

• Intern in Medicine
  University of Wisconsin Hospital and Clinics
  Madison, Wisconsin
  1985-86
• Resident in Internal Medicine
  Primary Care/Boise Tract, University of Washington at Seattle
  Seattle, Washington
  1986-88

Professional Memberships:

• American College of Physicians, Member, 1989
• Infectious Diseases Society of America, Member, 1994
• International Society of Analytical Cytometry, Member, 2000

Fellowships:

• Fellow in Infectious Diseases,
  University of Washington- Seattle
  Boise, Idaho
  1988-89
• Clinical Associate, HIV Outpatient Clinic
  Division of Infectious Diseases, New England
  Deaconess Hospital and Harvard Medical School
  Boston, Massachusetts
  1989-90
• Clinical Research Fellow in Infectious Diseases
  New England Deaconess Hospital and Harvard Medical School
  Boston, Massachusetts
  1990-93

Dr. Asmuth's research has primarily been in the area of HIV/ AIDS Pathogenesis and Treatment and HIV/HCV Co-Infection Pathogenesis and Treatment. His funding has included the Adult AIDS Clinical Trials Unit, the UTMB Small Grants Program, the UTMB President's Cabinet Award, a National Heart, Lung, and Blood Institute Contract, and currently a K23 mentored research award from the National Institute of Health.

The K23 Mentored Research Award has focused on effect of HIV infection on host cell cycle regulatory machinery. With the collaboration of R. Allen White, PhD of the Biomathematics Department of the MD Anderson Cancer Center in Houston, TX, Dr. Asmuth is measuring the duration of the phases of the cell cycle in both an in vitro model using HIV-infected normal lymphocytes and an ex vivo model using peripheral blood mononuclear cells and lymph node cells from HIV-infected subjects.

Selected Publications: Asmuth D.M., Olson R.D., Hackett S.P., Bryant A.E., Tweten R.K., Tso J.Y., Zollman T., Stevens D.L.: Effects of Clostridium perfringens recombinant and crude phospholipase C and q toxins on rabbit hemodynamic parameters. JID 172(5):1317-23, 1995.

Lyon R., Haque A.K., Asmuth DM, Woods GL: Changing patterns of infections in patients with AIDS: A study of 279 autopsies of prison inmates and nonincarcerated patients at a University Hospital in Eastern Texas, 1984-1993. CID 23(2): 241-47, 1996.

Lederman MM, Kalish LA, Asmuth DM, Fiebig E, Mileno M, Busch MP. Modeling relationships among HIV-1 replication, immune activation and CD4+ cell losses using adjusted correlative analyses. AIDS; 14(8): 951-958, 2000

Nokta MA, Li X-D, Nichols J, Mallen M, Pou A, Asmuth D, Pollard RB. Chemokine/CD4 receptor density ratios correlate with HIV replication in lymph nodes and peripheral blood of HIV infected individuals. AIDS, 15:161-169, 2001.

Collier AC, Kalish LA, Busch MP, Gernsheimer T, Assmann SF, Lane TA, Asmuth DM, Lederman MM, Murphy EL, Kumar P, Kelley M, Flanigan TP, McMahon DK, Sacks HS, Kennedy MS, Holland PV. Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection - The Viral Activation Transfusion Study: A randomized controlled trial. JAMA, 285(12): 1592-1601, 2001.

Nokta MA, Li X-D, Nichols J, Pou A, Asmuth D, Pollard RB. Homeostasis of naïve and memory T cell subpopulations in lymphoid tissues in the context of HIV infection. JID, 183(9): 1336-1342 2001.

Drew WL, Chou S, Miner RC, Mohr BA, Busch MP, van der Horst CM, Asmuth DM, Kalish LA, Cytomegalovirus glycoprotein B groups in HIV-infected patients with incident retinitis. JID 186(1): 114-117, 2002.

Nokta MA, Li X-D, McVey Z, Al-Harthi L, Pou A, Nichols J, Asmuth D, Landay A, Pollard RB. Entrapment of recent thymic emigrants and naïve CD4 T cells in lymphoid tissues from HIV infected patients: Association with HIV cellular viral load. AIDS 16(16): 2119-2127, 2002.

Asmuth DM, Kalish LA, Laycock M, Murphy EL, Mohr BA, Lee T-H, Gallarda J, Giachetti C, Dollard S, van der Horst C, Grant RM, Busch MP, for the Viral Activation Transfusion Study (VATS) Group. Absence of Hepatitis B and C viruses, Human T-Cell Leukemia Virus I/II and Human Herpes Virus-8 Activation Following Allogeneic Red Blood Cell Transfusion in Patients with Advanced HIV-1 Infection. Transfusion 43(4): 451-458, 2003.

Rossero R, Asmuth DM, Grady JJ, McKinsey DS, Green S, Andron L, Pollard RB. Hydroxyurea in combination with didanosine and stavudine in antiretroviral experienced HIV-infected subjects. Int J STD & AIDS, 14(5):350-355, 2003.