Welcome to the UC Davis MIND Institute » and Center for Excellence in Developmental Disabilities (CEDD) » resource page for 22q11.2 Deletion Syndrome.
What is 22q11.2 Deletion Syndrome?
Chromosome 22q11.2 deletion syndrome, also called velocardiofacial syndrome and DiGeorge syndrome, is caused by the deletion of a small segment of the long arm of chromosome 22 and is linked to over 180 physical, psychological and behavioral anomalies. Children with the syndrome experience some degree of developmental delay and learning difficulties. Most of these children have at least some of the following physical conditions: congenital heart defects, cleft palate or velopharyngealinsufficiencies, immune deficiencies or neonatal hypocalcemia. Likewise, most of them are at increased risk for some of the following behavioral and psychological disorders: attention deficit hyperactivity disorder, autism spectrum disorders, oppositional-defiant disorder, obsessive-compulsive disorder and schizophrenia.
- 22q Family Foundation »
- About Kids Health »
- Children’s Hospital of Philadelphia: 22q and You Center »
- IEP Workshop for Parents of kids with 22q11.2DS/VCFS - From Cincinnati Children's Hospital »
- Chromosome 22 Central »
- Cincinnati Children's Hospital 22q/VCFS Center »
- Dalglish Family Hearts and Minds Clinic for Adults with 22q11.2DS at University of Toronto »
- Dempster Family Foundation »
- Genetic Services from Elywn »
- International 22q11.2 Deletion Syndrome Foundation »
- VCFS/22q11 Foundation Australia »
- Virtual VCFS Center »
Medical Care Management
Medical Care Guidelines from International 22q11.2 Deletion Syndrome Consortium.
Bassett, A.S. et al. (2011) Practical guidelines for managing patients with 22q11.2 deletion syndrome. Journal of Pediatrics 159, 332–9. Article (PDF) »
Fung, W. L. A. et al. Practical guidelines for managing adults with 22q11.2 deletion syndrome. Genet Med (2015). doi:10.1038/gim.2014.175 Article (PDF) »
National Institutes of Health Information
Online Discussion Groups and Support for Parents or Affected Individuals
Congenital Heart Disease
The websites listed are independent of the UC Davis MIND Institute and Center for Excellence in Developmental Disabilities (CEDD). Resources are provided for information only and do not reflect the opinions or endorsement of the UC Davis MIND Institute and Center for Excellence in Developmental Disabilities.