Jinoh Kim, Ph.D.

Assistant Professor, Section of Genetics, Department of Pediatrics, School of Medicine

UC Davis M.I.N.D. Institute
Wet lab 1421
2805 50th Street
Sacramento, CA 95817
Tel: 916-703-0451
Fax: 916-703-0370
Email: jinoh.kim@ucdmc.ucdavis.edu

Dr. Kim is a cell biologist with expertise in intracellular protein trafficking. He is studying genetic disorders and bacterial infectious disease which cause defective protein transport from the endoplasmic reticulum (ER). Using biochemical and cell biological approaches, Dr. Kim has focused on biogenesis of gamma–secretase, an important enzyme complex responsible for generation of toxic amyloid peptide. He discovered that some familial Alzheimer’s disease (FAD)-linked presenilin 1 (PS1) mutant proteins cause aberrant export of gamma–secretase from the ER.  Dr. Kim’s laboratory is currently pursuing proteins recycling ER and Golgi compartments which control development of brain and other tissues.

B.S., Seoul National University
Ph.D., University of Connecticut
Postdoctoral training, UC-Berkeley

Kim, S.D., and Kim, J. 2008. Sequence analyses of presenilin mutations linked to familial Alzheimer’s disease. Cell Stress & Chaperones, in press.

Kim, J., B. Kleizen, R. Choy, G. Thinakaran, S.S. Sisodia, and R. Schekman. 2007. Biogenesis of gamma–secretase early in the secretory pathway. J. Cell Biol. 179: 951-963.

Kim, J., A. Thanabalasuriar, T. Chaworth-Musters, J.C. Fromme, E.A. Frey, P.I. Lario, P. Metalnikov, K. Rizg, N.A. Thomas, S.F. Lee. E.L. Hartland, P.R. Hardwidge, T. Pawson, N.C. Strynadka, B.B. Finlay, R. Schekman, and S. Gruenheid. 2007. The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COP II function.  Cell Host & Microbe 2: 160-171.

Sun, C., S.L. Rusch, J. Kim, and D.A. Kendall. 2007. Chloroplast SecA and Escherichia coli SecA have distinct lipid and signal peptide preferences. J. Bacteriol. 189: 1171-1175.

Kim, J., S. Hamamoto, M. Ravazzola, L. Orci, and R. Schekman. 2005. Uncoupled  packaging of amyloid precursor protein and presenilin 1 into COPII vesicles. J. Biol. Chem. 280: 7758-7768.

Kim, J., and Schekman, R. 2004. The ins and outs of presenilin 1 membrane topology.  Proc. Natl. Acad. Sci. USA 101: 905-906.

“FAD-linked presenilin 1 mutations show trafficking defects from the endoplasmic reticulum.” Minisymposium; Protein Misfolding and Disease, The American Society for Cell Biology. December 10 –14, 2005. San Francisco.

The American Society for Cell Biology

Ad hoc reviewer: Journal of Cell Biology, Proceedings of National Academy of Sciences (USA), Molecular Biology of the Cell.