Claudia M. Greco, M.D.

Assistant Professor, Department of Pathology, School of Medicine UC Davis M.I.N.D. Institute

UC Davis M.I.N.D. Institute
2825 50th Street
Sacramento, CA 95817
E-mail:  claudia.greco@ucdmc.ucdavis.edu

Dr. Greco joined the UC Davis Department of Pathology in 2000 as a specialist in anatomic pathology. A graduate of the Pennsylvania State University School of Medicine, Dr. Greco was recruited to UC Davis from Stanford University where she was clinical assistant professor in the Department of Pathology. Dr. Greco is board certified in pathology, with additional subspecialty certifications in anatomic pathology and neuropathology. Her research focus is in neuropathology, in particular neuromuscular diseases, neurodevelopmental disorders and forensic neuropathology. She assists the M.I.N.D. Institute with the acquisition and evaluation of brain material for understanding the pathophysiology of neurodevelopmental disorders.

B.A. Case Western Reserve University, Cleveland, Ohio, 1971
M.D. Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 1975

Hagerman PJ, Greco CM, Hagerman RJ. A cerebellar tremor/ataxia syndrome among fragile X premutation carriers. Cytogenet Genome Res 100: 206-12, 2003. Review of a newly-discovered neurodegenerative disorder in older adults that is caused by the same fragile X gene that gives rise to a neurodevelopmental disorder in childhood.

Leehey MA, Munholz RP, Lang AE, Bruanberg JA, Grisby J, Greco C, Jacquemont S, Tassone F, Lozano AM, Hagerman PJ, Hagerman RJ.  The Fragile X Premutation Presenting as Essential Tremor.  Arch Neurol 60: 117-212, 2003. This is a case report of two adult males who presented with essential tremor, but they really had FXTAS (Fragile X Tremor Ataxia Syndrome). The course of the syndrome, as well as problems associated with surgery in one of the cases is discussed.

Hagerman RJ, Leavitt BT, Farzin F, Jacquemont S, Greco CM, Brunberg JA, Tassone F, Hessl D, Harris SW, Zhang L, Jardini T, Gane LW, Ferranti J, Ruiz L, Leehey MA, Grigsby J, and Hagerman PJ.  Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) in Females with the FMR1 Premutation. Am J Hum Genet 74:1051-1056, 2004. Reports study demonstrating that older females with the premutation may also develop FXTAS.

Jacquemont S, Hagerman RJ, Leehey MA, Hall DA, Levine RA, Brunberg JA, Zhang Lin, Jardini T, Gane LW, Harris SW, Herman K, Grigsby J, Greco C, Berry-Kravis E, Tassone F, Hagerman PJ . Penetrance of the fragile X-associated tremor/ataxia syndrome (FXTAS) in a premutation carrier population: Initial results from a California family-based study. JAMA 291(4):460-469, 2004.  The fragile X permutation, which is associated with autism in some carriers, frequently leads to neurological problems in grandfathers.