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UC Davis MIND Institute

UC Davis MIND Institute

Flora Tassone, Ph.D.

Flora Tassone, Ph.D.

Research Biochemist, Department of Biochemistry and Molecular Medicine; Investigator, UC Davis MIND Institute, University of California, Davis
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone:  (916) 703-0463
E-mail:  ftassone@ucdavis.edu 

 

Dr. Flora Tassone received her B.S. degree in biology from the University of Rome “La Sapienza” and her Ph.D. from the University of Rome UCSC in 1992. She is a research biochemist in the Department of Biochemistry and Molecular Medicine, and a MIND Institute investigator at the University of California, Davis, School of Medicine. She is a molecular geneticist with a specialty in transcriptional and translational regulation of the fragile X (FMR1) gene. Dr. Tassone has made a number of important observations related to the mechanism of gene expression of the FMR1 gene, especially regarding the effects of premutation alleles on individuals the scientific community thought to be clinically unaffected. Specifically, she investigated the clinical manifestations, protein and FMR1 mRNA expression in individuals with fragile X syndrome and made the important discovery of gene dysregulation (increased activity) among premutation carriers. This discovery provided a molecular basis for the forms of clinical involvement among carriers, including fragile X- associated tremor ataxia syndrome (FXTAS). She continues to work on the molecular basis and abnormal molecular phenotype observed in individuals with FXTAS. Dr. Tassone is the director of the Molecular Core of a Fragile X project and she is the PI on a pilot study on Newborn Screening in Fragile X syndrome, funded by the NIH, the first of its kind in United States. Her laboratory provides the molecular support to a number of projects at the MIND Institute, as well as at the University of California, Davis. Her research also focuses on a number of other neurodevelopmental disorders including Autism Spectrum Disorders and 22q11.2 deletion syndrome.  Dr. Tassone has extensive experience in medical genetics and clinical analysis. She has been granted multiple fellowships and training opportunities, as well as research awards from NIH, the National Fragile X Foundation, and UC Davis Health System for her outstanding contributions to the field. Dr. Tassone is well known in the international Fragile X community; her work has been presented internationally and she has published extensively on the molecular aspect of both Fragile X and FXTAS and autism.

Education

B.S., Biology, University of Rome, 1983
Med Genetic, Medical Genetics, University of Rome, 1988
Ph.D., Molecular Biology, Catholic University of Rome, 1992


Click here (PDF) for a list of Dr. Tassone's publications and academic activities.