Jacqueline N. Crawley, Ph.D.
Robert E. Chason Endowed Chair in Translational Research, MIND Institute; University of California Davis School of Medicine Professor in Residence, Department of Psychiatry and Behavioral Sciences
UC Davis MIND Institute
Research II Room 1001A
4625 2nd Avenue
Sacramento, CA 95817
Phone: (916) 734-1129
Jacqueline N. Crawley, Ph.D. received her undergraduate education at the University of Pennsylvania in Philadelphia and graduated with a degree in biology. Her dissertation research was completed in the departments of zoology and psychology at the University of Maryland in College Park. Postdoctoral research in neuropsychopharmacology was conducted at Yale University School of Medicine. In 1979 she joined the Intramural Research Program at the National Institute of Mental Health in Bethesda, Maryland to establish a behavioral neuroscience laboratory. Her research program investigated animal models of neuropsychiatric disorders, including anxiety, depression, schizophrenia, and Alzheimer’s. She has published over 240 peer reviewed papers, 95 chapters and reviews, 5 books, and was editor of the journal Neuropeptides. Dr. Crawley’s sole-authored book, What’s Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, is in broad use by neuroscientists and the biomedical research community.
Beginning in 2000, Dr. Crawley’s interest in the genetics of autism led to a new focus on mutant mouse models of autism and other neurodevelopmental disorders. The Crawley lab conducts behavioral phenotyping of mice with mutations in genes associated with autism, to understand the consequences of each genetic abnormality across developmental stages. Her team innovated mouse behavioral assays with relevance to diagnostic symptoms including social approach, reciprocal social interactions, olfactory communication and ultrasonic vocalizations, motor stereotypies and repetitive behaviors, which have been widely adapted by many laboratories worldwide for investigations of animal models of neurodevelopmental disorders. Comprehensive behavioral phenotyping studies conducted by her group include mice with mutations in the autism risk genes engrailed2, fmr1, neuroligin1, neuroligin3, neuroligin4, shank1, shank3, as well as oxytocin, vasopressin 1b, 16p11.2 deletions, and inbred strains.
Dr. Crawley joined the University of California Davis in 2012 as a MIND Institute faculty member and Professor in the Department of Psychiatry and Behavioral Sciences. To discover effective therapeutics for the core symptoms of autism, the Crawley team is currently pursuing preclinical translational studies in mouse models with the most robust autism-relevant phenotypes, to identify pharmacological interventions that reverse and prevent autism-relevant behaviors.
Ph.D., Zoology, University of Maryland, College Park, MD, 1971-76
Postdoctoral, Yale University School of Medicine, New Haven, CT, 1976-79
Click here (PDF) for a list of Dr. Crawley's publications and academic activities.