Jill Silverman, Ph.D. - IDDRC Investigator

Jacqueline Crawley, Ph.D.

Assistant Adjunct Professor, UC Davis MIND Institute, Assistant Adjunct Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine 
UC Davis MIND Institute
4625 2nd Avenue, Research 2, Room 1001B
Sacramento, CA 95617


Phone: 916-734-8531
E-mail: jsilverman@ucdavis.edu 

Areas of Interest

Mouse Models of Autism, mouse behavioral assays, social, cognitive

Research

Dr. Silverman’s expertise is in preclinical translational evaluation of pharmacological treatments for autism spectrum disorders. Her research focus encompasses behavioral phenotypes of autism in genetic mouse models, environmental toxin effects on rat behaviors, interpretation of rodent behavioral data, pharmacological treatment reversals in mouse models of autism and the development of complex rodent behavioral tasks of executive function. Recent publications describe her discoveries of drug treatments that reduced repetitive behaviors and improved social behavior in mouse models of autism. Dr. Silverman leads projects in the Preclinical Autism Consortium for Therapeutics and serves as overall Manager of the IDDRC Rodent Behavior Core.

Recent Representative Publications

Silverman JL, Gastrell PT, Karras MN, Solomon M and Crawley JN (2014). Cognitive abilities on transitive inference using a novel touchscreen technology for mice.  Cerebral Cortex, in press.

Silverman JL, Oliver CF, Karras MN, Gastrell PT, and Crawley JN (2013) Ampakine enhancement of social interaction in the BTBR mouse model of autism. Neuropharmacology: Special Issue on Cognitive Enhancers. 64:268-82.

Silverman JL, Babineau BA, Oliver CF, Karras MN, Crawley JN (2013) Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism. Neuropharmacology: Special Issue on Neurodevelopmental Disorders, in press.

Silverman JL, Smith DG, Sukoff Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN (2012). Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.  Science Translational Medicine 4:131ra51.

Silverman JL, Turner SM, Barkan CL, Tolu SS, Saxena R, Hung AY, Sheng M, Crawley JN (2011) Sociability and motor functions in Shank1 mutant mice.  Brain Research Special Issue on The Emerging Neuroscience of Autism Spectrum Disorders, 1380: 120-137.