David Pleasure M.D. - IDDRC Investigator

David Pleasure M.D.

Director, Institute for Pediatric Regenerative Medicine, Distinguished Professor, Neurology and Pediatrics, UC Davis School of Medicine
Department of Neurology
c/o Shriners Hospitals for Children
2425 Stockton Blvd.
Sacramento, CA 95817

Phone: 916-453-2331 / Fax: 916-453-2288

Areas of Interest

Central Nervous System Development, Cerebral Palsy, Leukodystrophies, Central Nervous System Autoimmune Disorders

Research

David Pleasure, Director of the Institute for Pediatric Regenerative Medicine, is a clinical neurologist with interests in development of the central nervous system, periventricular leukomalacia (the most common cause of cerebral palsy), childhood leukodystrophies, and childhood-onset multiple sclerosis.  Current projects focus on the pathogenesis of Canavan leukodystrophy, the role of astroglial chemokines in central nervous system autoimmune diseases, and the normal control of oligodendroglial development.

Current IDDRC Projects

  • Will PEDF Therapy Reverse Chronic Demyelination and Prevent Axon Loss in EAE, Department of Defense, CDMRP MS110057.

Recent Representative Publications

Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D (2012) Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development.  Journal of Neuroscience, 32:639-645 (PMID: 22238099).

Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D (2012) PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.  Journal of Neuroscience, 32, 12152-12164 (PMID: 22933798).

Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, Guo F (2013) Adenomatous polyposis coli regulates oligodendroglial development.  Journal of Neuroscience, 33, 3113-3130 (PMID: 23407966).

Jiang P, Chen C, Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W (2013) hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.  Nature Communications, 4:2196 (PMID: 23880652).

Chetty S, Friedman AR, Travosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty A, Krishnamurthy A, Tsai M-K, Covarrubias D, Wong A, Francis D, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus.  Molecular Psychiatry, in press.