Izumi Maezawa, Ph.D. - IDDRC Investigator
Assistant Adjunct Professor, Department of Pathology and Laboratory Medicine, UC Davis Medical Center
UC Davis MIND Institute
2825 50th Street, Room 1417
Sacramento, CA 95817
Phone: 916-703-0392 / Fax: 916-703-0370
Areas of Interest
Rett syndrome, Neuroinflammation, Microglia Biology and Therapeutic Targets in Autism Spectrum Disorders
Dr. Maezawa has a strong interest in microglial biology. Her pioneer work on glial abnormalities in Rett syndrome, an autism spectrum disorder, provides a link between epigenetic regulation and glial function. Current projects in her laboratory are aimed at finding molecular targets on microglia for treatment of autism and Rett syndrome. She is co-inventor of several small molecule drug candidates for these disorders.
Current IDDRC Projects
- Glutamine Transporters SNAT1 and SNAT2 in Rett Syndrome Microglia, CMBG/ R21 HD073631
Recent Representative Publications
Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. (2009) Rett syndrome astrocytes are abnormal and spread the MeCP2 deficiency through gap junction. J Neurosci. 29:5051-5061. PMID: 19386901 *Editorial highlights in: Nat rev Neurosci. 10:396, 2009; Nat Med 15:620, 2009.
Maezawa I, Jin L-W. (2010) Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J Neurosci, 30:5346-5356. PMID: 20392956.
Maezawa I, Zimin P, Wulff H, Jin L-W. (2011) Aβ oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem, 286:3693-3706. PMCID: PMC3030372
Maezawa I, Calafiore M, Wulff H, Jin L-W. (2012) Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biology, 7:85-97.
Yasui D, Xu H, Dunaway KW, LaSalle JM, Jin L-W, Maezawa I. (2013) MeCP2 modulates gene expression pathways in astrocytes. Mol Autism, 4:3. PMCID: PMC3561260.