Jinoh Kim, Ph.D. - IDDRC Investigator
Assistant Professor, Department of Pediatrics, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 1421
Sacramento, CA 95817
Phone: 916-703-0451 / Fax: 916-703-0370
Areas of Interest
Intracellular Protein Trafficking, COPII Vesicle, Craniofacial Development, Endoplasmic Reticulum
Jinoh Kim is an Investigator of the IDDRC. Dr. Kim studies how secretory proteins exit the endoplasmic reticulum, the place where the secretory proteins are synthesized. Coat protein complex II (COPII) is responsible for ER export of the majority of secretory and membrane proteins. Defects in this machinery cause various human diseases. Dr. Kim’s laboratory focuses on a craniofacial disease that is caused by lesions in components of the COPII machinery. This disease manifests craniofacial abnormalities and developmental delay. Dr. Kim’s laboratory is set to delineate molecular mechanisms of this disease by using Cell Biological and Biochemical approaches.
Current IDDRC Projects
- Characterization of the interplay between SEC23A and the MAPK signaling pathway, NIDCR/NIH, R21 DE022419
Recent Representative Publications
Thanabalasuriar, A., J. Kim, and S. Gruenheid. 2013. The inhibition of COPII trafficking is important for intestinal epithelial tight junction disruption during enteropathogenic Escherichia coli and Citrobacter rodentium infection. Microbes and Infection 15:738-744.
Justice C.M., G. Yagnik, Y. Kim, I. Peter, E.W. Jabs, M. Erazo, X. Ye, L. Shi, M.L. Cunningham, V. Kimonis, T. Roscioli, S.A. Wall, A.O.M. Wilkie, J. Stoler, J.T. Richtsmeier, Y. Heuzé, P.A. Sanchez-Lara, M.F. Buckley, C.M. Druschel, J.L. Mills, M. Caggana, P.A. Romitti, D.M. Kay, C. Sanders, P.J. Taub, O.D. Klein, J. Boggan, M. Zwienenberg-Lee, C. Naydenov, J. Kim, A.F. Wilson, and S.A. Boyadjiev. 2012. A genome-wide association study identifies susceptibility loci for non-syndromic sagittal craniosynostosis near BMP2 and within BBS9. Nature Genetics 44:1360-1364.
Thanabalasuriar, A., J. Bergeron, A. Gillingham, M. Mimee, J.L. Thomassin, N. Strynadka, J. Kim, and S. Gruenheid. 2012. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cellular Microbiology 14:1206-1218.
Kim, S.D., K.B. Pahuja, M. Ravazzola, J. Yoon, S.A. Boyadjiev, S. Hamamoto, R. Schekman, L. Orci, and J. Kim. 2012. The SEC23-SEC31 interface plays a critical role for export of procollagen from the endoplasmic reticulum. Journal of Biological Chemistry 287:10134-10144.
Boyadjiev S.A., S.D. Kim, A. Hata, C. Haldeman-Englert, E.H. Zackai, C. Naydenov, S. Hamamoto, R.W. Schekman, and J. Kim. 2011. Cranio-Lenticulo-Sutural Dysplasia associated with defects in collagen secretion. Clinical Genetics 80:169-176.