Lee-Way Jin, M.D., Ph.D. - IDDRC Investigator
Professor and Director of Neuropathology, Department of Pathology and Laboratory Medicine, UC Davis School of Medicine
UC Davis MIND Institute
2805 50th Street, Room 1418
Phone: 916-703-0392 / Fax: 916-703-0272
Areas of Interest
Rett syndrome, Autism, Alzheimer’s disease, Neurochemistry, Neuroglia
Dr. Jin’s research is focused broadly on brain disorders affecting intellect and cognition. His laboratory employs multidisciplinary approaches to develop targeted therapies for Rett syndrome and Alzheimer’s disease. Promising compounds currently under intensive investigation include microglia potassium channel blockers, a group of neuroprotective tricyclic pyrone compounds, and neurosteroids. The goal of the laboratory is to provide improvement to the lives of many suffering from these brain disorders.
Current IDDRC Projects
- The role of astrocytes in Rett syndrome, NICHD/NIH, R01 HD064817
- Glutamine transporter SNAT1 and SNAT2 in Rett syndrome microglia, NICHD/NIH, R21 HD073631
Recent Representative Publications
Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin L-W. (2009) Rett syndrome astrocytes are abnormal and spread the MeCP2 deficiency state through gap junction. J Neurosci, 29:5051-5021.
Maezawa I, Jin L-W. (2010) Rett syndrome microglia damage dendrites and synapses by elevated release of glutamate. J Neurosci, 30:5346-5356.
Greco CM, Navarro C, Hunsaker MR, Maezawa I, Shuler J, Tassone F, Delany M, Au JW, Berman R, Jin L-W, Schumann C, Hagerman PJ, Hagerman RJ. (2011) Neuropathological features in the hippocampus and cerebellum of three older men with fragile X syndrome. Molecular Autism, :2.
Tassone F, Greco CM, Hunsaker MR, Seritan AL, Berman RF, Gane WL, Jacquemont S, Basuta K, Jin L-W, Hagerman PJ, Hagerman RJ. (2012) Neuropathological, clinical, and molecular pathology in female fragile X premutation carriers with and without FXTAS. Gene, Brain, & Behavior, 11:577-585.
Yasui D, Xu H, Dunaway KW, LaSalle JM, Jin L-W, Maezawa I. (2013) MeCP2 modulates gene expression pathways in astrocytes. Mol Autism, 4(1):3.