Jacqueline Crawley, Ph.D. - IDDRC Investigator
Faculty member, UC Davis MIND Institute, Robert E. Chason Endowed Chair in Translational Research,Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
4625 2nd Avenue, Research 2, Room 1001A
Sacramento, CA 95617
Phone: (916) 734-1129
Areas of Interest
Mouse Models of Autism, Behavioral Phenotypes, Drug treatments
Jacqueline Crawley is the Director of the IDDRC Rodent Behavior Core E. Dr. Crawley’s research program is focused on mouse models of autism to investigate hypotheses about causes and to discover effective treatments for the diagnostic symptoms. Her laboratory developed a constellation of mouse behavioral tests with face validity to the diagnostic and associated symptoms of autism, which has been widely adopted by the research community. Assays include social approach, reciprocal social interactions, social olfactory signals and responses, ultrasonic vocalizations, motor stereotypies, repetitive behaviors, perseveration, hyperactivity, anxiety-like, sensory reactivity, and cognitive abilities. Mouse models of neurodevelopmental disorders with intellectual disabilities are analyzed with subsets of these assays and an extensive set of learning and memory tasks. Pharmacological interventions that target pathways relevant to specific genetic mutations identified in monogenic neurodevelopmental disorders are evaluated in optimized mouse models. The mouse behavioral expertise of Dr. Crawley’s team is available to Users of the IDDRC Rodent Behavior Core.
Current IDDRC Projects
- Characterization of Brain and Behavior in 7q11.23 Duplication Syndrome, Simons Foundation, SFARI Award # 234798JC
- Convergent Synaptic Mechanisms in Neurodevelopmental Disorders, NINDS/NIH, R01NS085709
- Preclinical Consortium for Autism Therapeutics, Autism Speaks, Targeted Award #8703
Recent Representative Publications
Silverman JL, Gastrell PT, Karras MN, Solomon M and Crawley JN (2014). Cognitive abilities on transitive inference using a novel touchscreen technology for mice. Cerebral Cortex, in press.
Brielmaier J, Senerth JM, Silverman JL, Matteson PG, Millonig JH, DiCiccio-Bloom E, Crawley JN (2013). Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed2 knockout mice. Genes, Brain and Behavior, in press.
Silverman JL, Smith DG, Sukoff Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN (2012). Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Science Translational Medicine 4:131ra51.
Yang M, Bozdagi O, Scattoni ML, Wohr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Zhang J, Harris M, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN (2012). Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. The Journal of Neuroscience 32: 6525-6541.
Crawley JN (2004). Designing mouse behavioral tasks relevant to the symptoms of autism. Mental Retardation and Developmental Disabilities Research Reviews, Special Issue on Autism 10: 248-258.