Leonard Abbeduto, Ph.D.

Director, UC Davis MIND Institute and Tsakopoulos-Vismara Endowed Chair, Department of Psychiatry and Behavioral Sciences, School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2222
Sacramento, CA 95817 


Phone: 916-703-0234 / Fax: 916-703-0244
E-mail: ljabbeduto@ucdavis.edu 

Areas of Interest

Fragile X syndrome, Autism, Down syndrome, Language Development, Families

Research

Leonard Abbeduto is the Principal Investigator and Director of the IDDRC and Director of the UC Davis MIND Institute. Dr. Abbeduto’s research is focused broadly on the development of language across the lifespan in individuals with neurodevelopmental disorders, such as fragile X syndrome, Down syndrome, and autism.  He also is interested in the interplay between language development and comorbid conditions, such as anxiety, and in the family context for language development. Current projects are focused on understanding variation in language outcomes with and between various neurodevelopmental disorders, the measurement of treatment effects in clinical trials, the efficacy of parent-implemented language interventions, and the use of distance technology in behavioral treatment.

Current IDDRC Projects

  • Language development in fragile X syndrome, NICHD/NIH, R01 HD204356
  • Expressive language sampling as an outcome measure, NICHD/NIH, R01 HD074346
  • Social-affective bases of word learning in fragile X syndrome and autism, NICHD/NIH, R01 HD054764
  • Cognitive precursors of language impairment in Down syndrome, NICHD/NIH, R01 HD055345

Recent Representative Publications

Berry-Kravis, E., Doll, E.D., Sterling, A., Kover, S.T., Schroeder, S.M., Mathur, S., & Abbeduto, L. (2013). Development of an expressive language sampling procedure in fragile X syndrome: A pilot study. Journal of Developmental and Behavioral Pediatrics, 34, 245-251.

Kover, S.T., McDuffie, A., Hagerman, R.J., & Abbeduto, L. (2013). Receptive vocabulary in boys with autism spectrum disorder: Cross-sectional developmental trajectories. Journal of Autism and Developmental Disorders, 43, 2696-2709.

McDuffie, A., Kover, S.T., Hagerman, R.J., & Abbeduto, L. (2013). Investigating word learning in fragile X syndrome: A fast-mapping study. Journal of Autism and Developmental Disorders, 43, 1676-1691.

McDuffie, A., Machalicek, W., Oakes, A., Haebig, E., Ellis Weismer, S., & Abbeduto, L (2013). Distance video-teleconferencing in early intervention: Pilot study of a naturalistic parent-implemented language intervention. Topics in Early Childhood Special Education, 33, 172-185.

Pierpont, E.I., Richmond, E.K., Abbeduto, L., Kover, S.T., & Brown, W.T. (2011). Contributions of phonological and verbal working memory to language development in adolescents with fragile X syndrome. Journal of Neurodevelopmental Disorders, 3, 335-347.

David G. Amaral, Ph.D.Beneto Foundation Chair, MIND Institute; University of California Distinguished Professor, Department of Psychiatry and Behavioral Sciences and Center for Neuroscience, School of Medicine; Core Investigator, California National Primate Research Center

Phone:  916-703-0225
Email:  dgamaral@ucdavis.edu 

 

Joseph Anderson, Ph.D.

Assistant Professor, Department of Internal Medicine, Stem Cell Program, UC Davis School of Medicine
IRC Building
2921 Stockton Blvd, Room 1300
Sacramento, CA 95817 


Phone: 916-703-9300 / Fax: 916-703-9310
E-mail: joseph.anderson@ucdmc.ucdavis.edu

Areas of Interest

HIV Stem Cell Gene Therapy, Tay-Sachs, Sandhoff Disease

Research

Joseph Anderson is an Assistant Professor in the Department of Internal Medicine and is faculty in the UC Davis Stem Cell Program. Dr. Anderson’s research focuses on developing new therapies based on stem cell and gene therapy techniques. His recent work involving the development of a stem cell gene therapy strategy for HIV has progressed towards IND status and is currently being evaluated by the FDA. His new endeavors include a research project for Tay-Sachs disease using genetically modified blood stem cells.

Current IDDRC Projects

  • Expression of HexA/HexB via blood cells to cure Tay-Sachs disease, CTSF

Recent Representative Publications

Stem cell transplantation in the context of HIV--how can we cure HIV infection? Bauer G, Anderson JS. Expert Rev Clin Immunol. 2014 10(1):107-116.

CD25 preselective anti-HIV vectors for improved HIV gene therapy. Kalomoiris S, Lawson J, Chen RX, Bauer G, Nolta JA, Anderson JS. Hum Gene Ther Methods. 2012 23(6):366-375.

Fighting HIV with stem cell therapy: one step closer to human trials? Anderson JS, Bauer G. Expert Rev Anti Infect Ther. 2012 10(10):1071-1073.

Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. Walker JE, Chen RX, McGee J, Nacey C, Pollard RB, Abedi M, Bauer G, Nolta JA, Anderson JS. J Virol. 2012 86(10):5719-5729.

Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells. Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, Nacey C, McGee J, Lindsey M, Fury B, Bauer G, Nolta JA, Anderson JS. Mol Ther. 2011 19(3):584-593.

Karen L. Bales, Ph.D.

Professor and Vice-Chair, Department of Psychology, Unit Leader, Brain Mind and Behavior Unit, California National Primate Research Center, University of California, Davis
Department of Psychology
One Shileds Avenue
Davis, CA 95616


Phone: 530-754-5890 / Fax: 530-752-2087
E-mail: klbales@ucdavis.edu

Areas of Interest

Animal models, Autism, Social Behavior, Oxytocin

Research

Dr. Bales studies the physiology, neurobiology, and development of social bonding, particularly in monogamous species. She works with prairie voles (Microtus ochrogaster) and titi monkeys (Callicebus cupreus), species in which males and females form pair-bonds and males help take care of infants. In particular, she is interested in the role of neuropeptides such as oxytocin and vasopressin in the neurobiology and development of social behavior, and their use in human health practices such as labor induction and intranasal use in autism and schizophrenia.

Current IDDRC Projects

  • Effects of chronic intranasal oxytocin, NICHD/NIH, R01 HD071998

Recent Representative Publications

Millan, M.J., Bales, K.L. (2013) Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: the CNTRICS initiative.  Neuroscience and Biobehavioral Reviews, epub ahead of print.

Ragen, B.J., Maninger, N., Mendoza, S.P., Jarcho, M.R., Bales, K.L. (2013) Presence of a pair-mate regulates the behavioral and physiological effects of opioid manipulation in the monogamous titi monkey (Callicebus cupreus).  Psychoneuroendocrinology, 48, 2448-2661. PMCID:3812423

Miller, M., Bales, K.L., Taylor, S.L., Yoon, J., Hostetler, C.M., Carter, C.S., Solomon, M. (2013) Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms. Autism Research, 6, 91-102. PMCID:3657571

Bales, K.L., Perkeybile, A.M., Conley, O.G., Lee, M.H., Guoynes, C.D., Downing, G.M., Yun, C.R., Solomon, M., Jacob, S., Bales, K.L. (2013) Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles.  Biological Psychiatry, 74, 180-188.  PMCID: 3556198

Bales, K.L., Perkeybile, A.M. (2012) Developmental experiences and the oxytocin receptor system. Hormones and Behavior, 61, 313-319.

Melissa D. Bauman, Ph.D.

Assistant Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 1416
Sacramento, CA 95817


Phone: 916-703-0377 / Fax: 916-703-0370
E-mail: mdbauman@ucdavis.edu 

Areas of Interest

Animal Models, Nonhuman Primates, Neurodevelopmental Disorders, Autism, Schizophrenia

Research

Dr. Bauman is an assistant professor in the UC Davis Department of Psychiatry and Behavioral Sciences and a faculty member of the UC Davis MIND Institute.  Dr. Bauman’s research focuses on the neural basis of social development, integrating basic neuroscience, behavior and immunological approaches to understand how primates develop species-typical social behavior. Her translational research utilizes sophisticated animal models to examine risk factors and develop novel therapeutic interventions for neurodevelopmental disorders, such as autism and schizophrenia. Dr. Bauman’s current research efforts focus on changes in the prenatal environment, in particular activation and/or abnormalities in the mother’s immune system, which may act as a "neurodevelopmental disease primer" in exposed offspring.

Current IDDRC Projects

  • Neuroimmune mechanisms of psychiatric disorders (Novel Model System Core), NIH P50 MH106438-01

Recent Representative Publications

Bauman, M.D., Iosif, A., Smith, S.E.P., Bregere, C., Amaral, D.G., Patterson, P.H. (2013). Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biological Psychiatry. Sep 4. pii: S0006-3223(13)00673-2. doi: 10.1016/j.biopsych.2013.06.025. [Epub ahead of print].

Bauman, M.D., Iosif, A., Ashwood, P., Braunschweig, D. Van de Water, J. Lee, A., Schumann, C.M., Amaral, D.G. (2013). Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Translational Psychiatry, 3, e278; doi:10.1038/tp.2013.47

Bauman, M.D., & Schumann, C.M. (2013). Is “Bench-to-Bedside” Realistic for Autism? An Integrative Neuroscience Approach. Neuropsychiatry. , 3(2), 159-168.

Schumann, C. M., Bauman, M.D., & Amaral, D. G. (2011). Aberrant amygdala structure or function is a common component of neurodevelopmental disorders. Neuropsychologia. 2011 Mar;49(4):745-59. Epub 2010 Oct 13.

Bauman, M. D., Crawley, J. N., Berman, R. F. (2010).  Autism:  Animal models.  In:  Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd. Chichester. pp1-10, DOI: 10.1002/9780470015902.a0022368.

Robert F. Berman, Ph.D.

Professor and Vice Chair of Research, Department of Neurological Surgery, UC Davis School of Medicine
University of California Davis
1515 Newton Court
Davis, CA 95618


Phone: 530-754-5102 / Fax:  530-754-5125
E-mail: rfberman@ucdavis.edu 

Areas of Interest

Neurodevelopmental Disorders, Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS), Fragile-X Premutation, Animal Models of Autism, Traumatic Brain Injury

Research

Dr. Berman is Director of Research for the Department of Neurological Surgery at UC Davis, and a faculty member at the UC Davis MIND Institute and the Center for Neuroscience.   He is also Co-director with Dr. Jacqueline Crawley of Core E, Animal Models, within the UC Davis IDDRC.  Dr. Berman’s research is broadly focused on understanding  the causes and cellular mechanisms of Fragile X-associated disorders (i.e., Fragile-X premutation, FXTAS), autism and traumatic brain injury.  Current research is using transgenic mouse models to understand the disease processes underlying these disorders, as well as to develop and test pharmacological and molecular treatment strategies to improve neurological function.

Current IDDRC Projects

  • Mouse models to define critical periods and molecular targets in FXTAS, NIH/NINDS R01 NS079775
  • Behavioral Characterization of a Rat Model of Alexander Disease, NS079775 (rfb) & HD076892 (AM)

Recent Representative Publications

Berman, R.F., Murray, K.D., Arque, G., Hunsaker, M.R. & Wenzel, H.J. (2012), Abnormal dendrite and spine morphology in primary visual cortex in the CGG, knock-in model of the Fragile X premutation. Epilepsia 53, 149-159.  PMID:22612820

Tasone, F., Greco, C., Hunsaker, M., Berman, R., Seritan, A., Gane, L., Jacquemont, S., Basuta, K., Jin, L-W, Hagerman, P. and Hagerman, R. (2012) Neuropathological, clinical and molecular pathology in female fragile x premutation carriers with and without FXTAS. Genes Brain and Behavior. 11,577-585. PMID:22463693

Hunsaker, M.R., Kim, K.M., Willemsen, R. & Berman, R.F. (2012) CGG Trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the Fragile X premutation. Hippocampus , 22 (12), 2260-2275.  PMID:22707411

Koenig, C.M., Lango, J., Pessah, I.N. &  Berman, R.F. (2012) Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicology and Teratology, 34(6), 571-80.  PMID:23022914

Schwartzer, J., Koenig, C.M. & Berman, R.F. (2013) Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.  Neurotoxicology and Teratology, 36, 17-35.  PMID: 23010509

Cameron Carter, M.D.

Interim Vice Chancellor for Research
Director, Behavioral Health Center for Excellence and the Early Psychosis Research and Clinical Programs

Phone: 916-734-7783
Email:  cscarter@ucdavis.edu

Jacqueline Crawley, Ph.D.

Faculty member, UC Davis MIND Institute, Robert E. Chason Endowed Chair in Translational Research,Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine 
UC Davis MIND Institute
4625 2nd Avenue, Research 2, Room 1001A
Sacramento, CA 95617

Phone: 916-734-1129  
E-mail: crawley@ucdavis.edu 

Areas of Interest

Mouse Models of Autism, Behavioral Phenotypes, Drug treatments

Research

Jacqueline Crawley is the Director of the IDDRC Rodent Behavior Core E.  Dr. Crawley’s research program is focused on mouse models of autism to investigate hypotheses about causes and to discover effective treatments for the diagnostic symptoms.   Her laboratory developed a constellation of mouse behavioral tests with face validity to the diagnostic and associated symptoms of autism, which has been widely adopted by the research community.   Assays include social approach, reciprocal social interactions, social olfactory signals and responses, ultrasonic vocalizations, motor stereotypies, repetitive behaviors, perseveration, hyperactivity, anxiety-like, sensory reactivity, and cognitive abilities.  Mouse models of neurodevelopmental disorders with intellectual disabilities are analyzed with subsets of these assays and an extensive set of learning and memory tasks.  Pharmacological interventions that target pathways relevant to specific genetic mutations identified in monogenic neurodevelopmental disorders are evaluated in optimized mouse models.  The mouse behavioral expertise of Dr. Crawley’s team is available to Users of the IDDRC Rodent Behavior Core.

Current IDDRC Projects

Recent Representative Publications

Silverman JL, Gastrell PT, Karras MN, Solomon M and Crawley JN (2014). Cognitive abilities on transitive inference using a novel touchscreen technology for mice.  Cerebral Cortex, in press.

Brielmaier J, Senerth JM, Silverman JL, Matteson PG, Millonig JH, DiCiccio-Bloom E, Crawley JN (2013).  Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed2 knockout mice.  Genes, Brain and Behavior, in press.

Silverman JL, Smith DG, Sukoff Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN (2012). Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.  Science Translational Medicine 4:131ra51.

Yang M, Bozdagi O, Scattoni ML, Wohr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Zhang J, Harris M, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN (2012). Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. The Journal of Neuroscience 32: 6525-6541.

Crawley JN (2004). Designing mouse behavioral tasks relevant to the symptoms of autism.  Mental Retardation and Developmental Disabilities Research Reviews, Special Issue on Autism 10: 248-258.

Randi Hagerman, M.D.

Medical Director, UC Davis MIND Institute, Distinguished Professor, Endowed Chair in Fragile X Research, Department of Pediatrics, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2221
Sacramento, CA 95817


Phone: 916-703-0247/ Fax: 916-703-0240
E-mail: rjhagerman@ucdavis.edu 

Areas of Interest

Targeted treatments in fragile X syndrome (FXS), Autism Spectrum Disorders and FXTAS, Premutation involvement at all ages, Aging studies in FXS and FXTAS and molecular-clinical correlations in those with fragile X mutations

Research

Dr. Randi Hagerman is interested in a variety of treatments for children with neurodevelopmental disorders including fragile X syndrome (FXS), premutation involvement and autism spectrum disorders (ASD). She is currently carrying out several controlled trials of targeted treatments for FXS including ganaxolone, sertraline, AFQ056 and RO491753; the latter two are mGluR5 antagonists which will also likely be helpful for premutation involvement and in children with ASD. The combination of targeted treatments and education/behavioral interventions is also an important research endeavor that is highlighted in our IDDRC, specifically the combination of parent implemented language intervention combined with lovastatin, another targeted treatment for FXS. Studies regarding premutation involvement have focused on comorbidities, prevention and treatment of those with the fragile X-associated tremor/ataxia syndrome (FXTAS). She has completed a memantine study and will carry out an allopregnanolone study in the future in those with FXTAS. The premutation neuron is also vulnerable to a variety of environmental toxins and background genetic effects which can enhance the penetrance of clinical involvement. The role of mitochondrial dysfunction in premutation involvement and mechanisms of RNA toxicity are studied jointly with a molecular team including Drs. Paul Hagerman, Flora Tassone, Isaac Pessah and Cecilia Guilivi.

Current IDDRC Projects

  • Genotype-Phenotype Relationships in Fragile X Families, NICHD, R01HD036071
  • Treatment of Fragile X Syndrome with a Neuroactive Steroid, DOD, PR101054
  • Controlled Trial of Sertraline in Young Children with Fragile X Syndrome, HRSA, R40MC22641

Recent Representative Publications

Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, Hagerman RJ. (2013). A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome. J Dev Behav Pediatr. 34(3):147-155.

Hagerman R, Hagerman P.  (2013). Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome (FXTAS). Lancet Neurol . 12(8):786-98.

Hagerman R, Lauterborn J, Au J, Berry-Kravis E. (2012). Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ. 54:297-35.

Tassone F, Long KP, Tong TH, Lo J, Gane LW, Berry-Kravis E, Nguyen D, Mu LY, Laffin J, Bailey DB, Hagerman RJ. (2012). FMR1 CGG allele size and prevalence ascertained through newborn screening in the United States. Genome Med. 4(12):100-13.

Tassone F, Greco CM, Hunsaker MR, Seritan AL, Berman RF, Gane LW, Jacquemont S, Basuta K, Jin LW, Hagerman PJ, Hagerman RJ. (2012). Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav. 11(5):577-85.

Paul J. Hagerman, M.D., Ph.D.

Distinguished Professor, Department of Biochemistry and Molecular Medicine, Investigator, MIND Institute, UC Davis School of Medicine
University of California, Davis
One Shields Avenue, 4455 Tupper Hall
Davis, CA 95616


Phone:  530-754-7266 / Fax: 530-754-7269
E-mail: pjhagerman@ucdavis.edu 

Areas of Interest

Fragile X Syndrome, Fragile X-Associated Tremor/Ataxia Syndrome, Premutation, FMR1 Gene, Neurodegeneration

Research

Dr. Paul Hagerman is a molecular geneticist with a principal interest in understanding the basis for neurodevelopmental and neurodegenerative diseases. In particular, the Hagerman lab has made a number of important observations related to the mechanism of gene expression of the fragile X (FMR1) gene. Mutations of the FMR1 gene give rise to fragile X syndrome, the leading heritable form of mental impairment and autism, and premutation-related disorders, such as fragile X-associated tremor/ataxia syndrome (FXTAS). With features of Parkinsonism and dementia, FXTAS represents a model system for understanding the basic cell mechanisms underlying more common disorders such as Parkinson’s and Alzheimer’s diseases.

Current IDDRC Projects

  • Expression Of The Fragile X Mental Retardation 1 (FMR1) Gene, NIH, R01 HD072060

Recent Representative Publications

Ludwig AL, Espinal GM, Pretto D, Jamal AL, Arque G, Tassone F, Berman RF & Hagerman PJ (2014) CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size. Human Molecular Genetics In Press. doi:10.1093/hmg/ddu032.

Loomis EW, Eid JS, Peluso P, Yin J, Hickey L, Rank D, McCalmon S, Hagerman RJ, Tassone F & Hagerman PJ (2013) Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene. Genome Research 23:121-128.

Hagerman R & Hagerman P (2013) Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurology 12:786-798.

Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ (2012) Signaling defects in iPSC-derived fragile X premutation neurons. Human Molecular Genetics 21:3795-805.

Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE & Hagerman PJ (2011) CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Human Molecular Genetics 20:2161-2170.

Tim Hanks, Ph.D.

Assistant Professor, Neurology

Email: thanks@ucdavis.edu

Irva Hertz-Picciotto, Ph.D., M.P.H.Professor and Vice Chair for Research, Department of Public Health Sciences, School of Medicine. Director, NIH-funded UC Davis Environmental Health Sciences Core Center. Director, Program on Environmental Epidemiology of Autism and Neurodevelopment, the CHARGE (CHildhood Autism Risk from Genes and the Environment), and MARBLES (Markers of Autism Risk in Babies — Learning Early Signs) Studies

Phone:  530-752-3025
E-mail:  iher@ucdavis.edu

David Hessl, Ph.D.Director, Translational Psychophysiology and Assessment Laboratory (T-PAL), MIND Institute. Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2273
Sacramento, California 95817



Phone: 916-703-0249 / Fax: 916-703-0244
E-mail: drhessl@ucdavis.edu

Areas of Interest

Fragile X syndrome, Fragile X Premutation, FXTAS, Autism, Down syndrome, Intellectual Disabilities

Research

David Hessl is the Director of the Translational Psychophysiology and Assessment Laboratory (T-PAL) and Co-Director of the Neurobehavioral Analysis Core of the IDDRC. Dr. Hessl’s research is focused broadly on elucidating the behavioral, cognitive and physiological basis of fragile X-associated disorders and autism, and on the development of novel outcome measures for treatment studies. Current projects are focused on identifying markers of neurodegeneration in premutation carriers, evaluation of the efficacy of cognitive training and behavioral treatment for children with fragile X syndrome, and development and validation of cognitive tests for use as outcome measures in clinical trials for fragile X and Down syndromes, and other forms of intellectual disabilities.

Current IDDRC Projects

  • Trajectories and Markers of Neurodegeneration in Carriers of the Fragile X Premutation, NIMH/NIH, R01 MH078041
  • Cognitive Training for Fragile X Syndrome, John Merck Fund Developmental Disabilities Translational Research Grant

Recent Representative Publications

Sansone SM, Schneider A, Bickel E, Berry-Kravis E, Prescott C, & Hessl D (In press). Improving IQ measurement in intellectual disabilities using true deviation from population norms. Journal of Neurodevelopmental Disorders.

Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E, Lachiewicz A, Brown EC, & Hessl D (2011). Psychometric study of the Aberrant Behavior Checklist in fragile X syndrome and implications for targeted treatment. Journal of Autism and Developmental Disorders 42(7), 1377-1392.

Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Tassone F, Hagerman PJ, & Rivera SM (2011). Deficient FMRP underlies amygdala dysfunction in carriers of the fragile X premutation. Biological Psychiatry, 70(9), 859-865.

Farzin F, Scaggs F, Hervey C, Berry-Kravis E, & Hessl D (2011). Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome. Journal of Autism and Developmental Disorders, 41(11), 1515-1522.

Hessl D, Cordeiro L, Yuhas J, Campbell A, Ornitz E, Berry-Kravis E, Chruscinski E, Hervey C, Long JM, & Hagerman RJ (2009). Prepulse inhibition in fragile X syndrome: Feasibility, reliability and implications for treatment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B(4) 545-553.

Janine LaSalle, Ph.D.

Professor, Medical Microbiology and Immunology, UC Davis Genome Center, UC Davis MIND Institute
Medical Microbiology and Immunology
One Shields Avenue
Davis, CA 95616


Phone: 530-754-7598 / Fax: 530-752-8692
E-mail: jmlasalle@ucdavis.edu 

Areas of Interest

Epigenetics, Autism, Rett syndrome, Prader-Willi syndrome, Duplication 15q11-q13 Syndrome, Environmental Epigenetics

Research

Dr. LaSalle is a Professor of Microbiology and Immunology at the University of California, Davis, with memberships in the Genome Center, and the MIND Institute.  Dr. LaSalle serves as Chair of the Integrative Genetics and Genomics graduate group at UC Davis.  Dr. LaSalle also serves on the editorial board of the journals Human Molecular Genetics, Molecular Autism, and OA Autism and is on the Scientific Advisory boards of the International Rett Syndrome Foundation and the Dup15q Alliance.  The research focus in Dr. LaSalle’s laboratory is on epigenetics of neurodevelopmental disorders, including autism, Rett, Prader-Willi, Angelman, and Dup15q syndromes. Dr. LaSalle’s laboratory uses genomic and epigenomic technologies to investigate the role of DNA methylation and MeCP2 in the pathogenesis of Rett syndrome and autism spectrum disorders. Dr. LaSalle’s lab has more recently been taking integrative genetic and epigenomic approaches to investigate to role of persistent organic pollutants such as flame retardant PBDEs and long lived PCBs and the protective effect of folate and prenatal vitamin use on the methylome.

Current IDDRC Projects

  • Methylomic and Genomic Impacts of Organic Pollutants in Dup15q syndrome, NIEHS/NIH, 1R01ES021707-02

Recent Representative Publications

Woods R, Vallero RO, Golub M, Suarez JK, Ta TA, Yasui DH, Chi L-H, Kostyniak PJ, Pessah, IN, Berman RF, LaSalle JM.  2012.  Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation.  Hum. Mol Genet, 21:2399-2411.

Schroeder DI, Blair J, Lott P, Yu HO, Hing, D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, and LaSalle JM.  2013.  The human placental methylome.  Proc. Natl. Acad. Sci., 110:6037-6042.

Powell WT, Coulson RL, Crary FK, Gonzales ML, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chedin F, and LaSalle JM.  2013. Topotecan stabilizes R-loops to inhibit transcription in the Prader-Willi/Angelman imprinted locus.  Proc. Natl. Acad. Sci., 110:13938-13943.

Powell WT, Coulson RL, Crary FK, Wong SG, Ach RA, Tsang P, Yamada NA, Yasui DH, and LaSalle JM.  2013.  A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum. Mol Genet, 22:4318-4328.

Yasui DH, Schanen NC, Aflatooni JO, Golub MS, LaSalle JM.  2014.  Mice with a single nucleotide isoform-ablating Mecp2-e1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum. Mol Genet.

Pamela J. Lein, Ph.D.Director, UC Davis CounterACT Center of Excellence, Director, NIEHS Training program in Environmental Health Sciences, Chair, Pharmacology and Toxicology Graduate Group, Professor and Vice-Chair, Department of Molecular Biosciences, UC Davis School of Veterinary Medicine
Department of Molecular Biosciences, UC Davis School of Veterinary Medicine
1089 Veterinary Medicine Drive, 2009 VM3B
Davis, California 95616

Phone: 530-752-1970 / Fax: 530-752-7690
E-mail: pjlein@ucdavis.edu 

Areas of Interest

Autism Spectrum Disorders, Developmental Neurotoxicology, Gene X Environment Interactions, Neuronal Connectivity, Persistent Organic Pollutants, Pesticides

Research

Pamela Lein is the Co- director of the IDDRC Biological Analysis Core, Director of the UC Davis Center CounterACT Center of Excellence and faculty member of the Center for Children’s Environmental Health. Dr. Lein’s research is focused on characterizing how developmental neurotoxicants interfere with normal neurodevelopment, and how these may interact with genes of susceptibility to influence the risk and/or severity of neurodevelopmental disorders. She is also interested in the relationship between immune development and neurodevelopment, and how environmental exposures may disrupt the normal relationship between these two systems in development. Current projects are focused on understanding how organophosphate pesticides (OPs) and polychlorinated biphenyls (PCBs) and autism-related immune factors alter normal patterns of neuronal connectivity.

Current IDDRC Projects

  • Molecular and Cellular Basis of PCB Developmental Neurotoxicity, NIH/NIEHS R01 ES014901
  • Mitigation of Neurological Damage Following Seizures, NIH/NINDS U54 NS079202

Recent Representative Publications

Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ (2014) PCB136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci.

Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ*, Wayman GA (2014) The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3): 717-25. *Corresponding author

Stamou M, Streifel KM, Goines PE and Lein PJ (2013) Neuronal connectivity as a convergent target of gene-environment interactions that confer risk for Autism Spectrum Disorders.  Neurotoxicol Teratol 36: 3-16. PMC3610799

Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ (2012) PCB 95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect 120(7): 997-1002. PMC3404670

Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ (2012) PCB 95 modulates calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect 120(7):1003-9. PMC3404671

Steven J. Luck, Ph.D.

UC Davis Center for Mind & Brain, Professor, UC Davis Department of Psychology
UC Davis Center for Mind & Brain
267 Cousteau Place
Davis, California 95618



Phone: 530-752-3025 / Fax: 530-752-3329
E-mail: sjluck@ucdavis.edu 

Areas of Interest

Attention, Working Memory, Human Electrophysiology, Schizophrenia

Research

Steve Luck is the Director of the UC-Davis Center for Mind & Brain, a MIND Institute faculty member, and a co-director of the IDDRC’s Neurobehavioral Analysis Core. Dr. Luck's research focuses on the neural and cognitive mechanisms of attention and working memory in healthy young adults, the development of these functions in typical infants, and dysfunctions these functions in psychiatric and neurological conditions such as schizophrenia.  He is also one of the world’s leading experts on event-related potentials (ERPs), which provide a safe and painless means of measuring the brain’s electrical activity from the scalp in humans.  In addition to using ERPs to study typical and atypical cognitive function, Dr. Luck leads a yearly 10-day NIH-funded summer workshop on ERPs (the ERP Boot Camp) and supervises the development of an open-source Matlab toolbox (ERPLAB Toolbox).

Current IDDRC Projects

  • Cognitive Neuroscience of Attention and Working Memory in Schizophrenia, NIMH/NIH R01 MH65034

Recent Representative Publications

Luck, S. J. (2014). An Introduction to the Event-Related Potential Technique, Second Edition. Cambridge, MA: MIT Press.

Luck, S. J., & Vogel, E. K. (2013). Visual Working Memory Capacity: From Psychophysics and Neurobiology to Individual Differences. Trends in Cognitive Sciences, 17, 391-400.

Oakes, L. M., Baumgartner, H. A., Barrett, F. S., Messenger, I. M., & Luck, S. J. (2013). Developmental changes in visual short-term memory in infancy: Evidence from eye-tracking. Frontiers in Developmental Psychology, 4-697, 1-13.

Leonard, C. J., Kaiser, S. T., Robinson, B. M., Kappenman, E. S., Hahn, B., Gold, J. M., & Luck, S. J. (2012). Toward the neural mechanisms of reduced working memory capacity in schizophrenia. Cerebral Cortex , 23, 1582-1592.

Sawaki, R., Geng, J. J., & Luck, S. J. (2012). A common neural mechanism for preventing and terminating attention. Journal of Neuroscience, 32, 10725-10736.

A. Kimberley McAllister, Ph.D.

Director, UC Davis Center for Neuroscience
Center for Neuroscience
1544 Newton Court
Davis, CA 95618 



Phone: 530-752-8114 Fax: 530-757-8827
E-mail: kmcallister@ucdavis.edu  

Areas of Interest

Developmental Neurobiology, Autism, Schizophrenia, Neuroimmunology, Synapse Formation, Synaptic Plasticity

Research

Dr. McAllister’s research is focused on studying the cellular and molecular mechanisms underlying the formation of synaptic connections in the cerebral cortex during development and in neurodevelopmental disorders. Many of the genes that have been associated with neurodevelopmental disorders, such as autism and schizophrenia, encode synaptic proteins that are studied n the McAllister Lab. In addition, Dr. McAllister is also interested in understanding the role for immune molecules on neurons in regulating brain development and how they mediate the effects of environmental risk factors in neurodevelopmental disorders. Current projects are focused on understanding the mechanisms underlying the roles for neuroligin and Shank proteins in synapse dynamics during early cortical development, the role for cytokines and major histocompatibility complex I molecules in limiting synapse formation and in mediating the effects of maternal immune activation on brain development, and in targeting recently identified cytokine receptors in the brain for development of new diagnostic tools and therapies for neuro-immune-based psychiatric disorders.

Current IDDRC Projects

  • Neuroimmune mechanisms of psychiatric disorders, NIHP50MH106438-01

Recent Representative Publications

McAllister AK (2014) Major histocompatibility complex I in brain development and schizophrenia. Biol Psychiatry. 75(4):262-8.

Elmer, BM, Estes ML, Barrow SL, and McAllister AK (2013) MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J Neurosci. 33:13791-804.

Garay PA, Hsiao EY, Patterson PH, and McAllister AK (2012) Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development. Brain Behav Immun. 31:54-68.

Glynn MS, Elmer BM, Garay PA, Liu X-B, El-Sabeawy FE, Needleman LN, and McAllister AK. (2011) Class I MHCI molecules negatively regulate the initial establishment of cortical connectivity. Nature Neuroscience 14:442-451.

Needleman LN, Liu XB, Jones EG and McAllister AK (2010) MHC class I molecules are present both pre- and postsynaptically in the visual cortex during postnatal development and in adulthood., PNAS USA 107:16999-7004.

Meghan Miller, Ph.D.

Assistant Professor, Department of Psychiatry & Behavioral Sciences
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone:  916-703-0217
Email:  mrhmiller@ucdavis.edu

Current IDDRC Projects

  • Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum Disorder, NIMH K99MH106642/R00MH106642

Stephen C. Noctor, Ph.D.

Assistant Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817


Phone: 916-703-0435
Email: scnoctor@ucdavis.edu 

Areas of Interest

Fragile X Premutation, Autism, Schizophrenia, Cortical Development, Neural Precursor Cells, Neurogenesis

Research

Dr. Stephen Noctor investigates development of the cerebral cortex under normal and pathological conditions.  Studies in the Noctor lab center on factors that regulate the production of neural and glial cells, and the migration of newborn neurons. Current projects are focused on how neural-immune interactions in the prenatal brain regulate precursor cell function. Additional work in the lab is identifying and phenotyping cortical neural precursor cells in the fetal non-human primate model. 

Current IDDRC Projects

  • Microglia regulate development of the cerebral cortex, NIMH/NIH, R01 MH101188

Recent Representative Publications

Cunningham CL, Martinez-Cerdeno V, Noctor SC (2013) Microglia regulate the number of neural precursor cells in the developing cerebral cortex. Journal of Neuroscience, 33(10): 4216-4233.

Cunningham CL, Martinez-Cerdeno V, Noctor SC (2013). Diversity of neural precursor cell types in the prenatal macaque cerebral cortex exists largely within the astroglial cell lineage. PLoS One, 8(5): e63848.

Cunningham CL, Martinez-Cerdeño V, Navarro E, Prakash A, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. (2011). Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Human Molecular Genetics, 20(1): 64-79.

Noctor SC, Flint AC, Weissman TA, Dammerman RS, Kriegstein AR. (2001). Neurons derived from radial glial cells establish radial units in neocortex. Nature; 409:714-720.

Noctor SC, Martínez-Cerdeño V, Ivic L, Kriegstein AR. (2004). Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nature Neuroscience; 7:136-44. 

Christine Wu Nordahl, Ph.D.

Assistant Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817


Phone: 916-703-0373 / Fax: 916-703-0370
Email: cnordahl@ucdavis.edu 

Areas of Interest

Autism, Neuroimaging, Brain Structure, Connectivity, Development

Research

Dr. Nordahl’s research is focused on understanding the neural basis of autism spectrum disorder. She utilizes structural and functional neuroimaging to investigate alterations in brain structure and connectivity in toddlers with autism. Her current research projects are aimed at identifying meaningful subgroups or phenotypes of children with autism spectrum disorder based on behavioral, immunological, and neuroimaging data.  She is also interested in evaluating how factors such as biological sex modulate both typical and atypical brain development during early childhood.

Current IDDRC Projects

  • Neural Phenotypes of Females with Autism Spectrum Disorder, NIMH, R01 MH104438-01

Recent Representative Publications

Johnson RT, Yeatman JD, Wandell BA, Amaral DG, Nordahl CW. (2013) Diffusion properties of major white matter tracts in young, typically developing children. Neuroimage, in press

Shen MD, Nordahl CW, Young GS, Wooton-Gorges SL, Lee A, Liston SE, Harrington K, Ozonoff S, Amaral DG. (2013) Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder, Brain, 136; 2825-35.

Nordahl CW, Braunschweig D, Iosif A-M, Lee A, Rogers SJ, Ashwood P, Amaral DG, Van de Water, J. (2013) Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder. Brain Behavior and Immunity, 30:61-5.

Nordahl CW, Scholz R, Yang X, Buonocore MH, Simon T, Rogers S, Amaral DG (2012) Increased rate of amygdala growth in children aged 2 to 4 years with autism spectrum disorders: a longitudinal study. Archives of General Psychiatry 69:53-61.

Nordahl CW, Lange N, Li DD, Barnett LA, Lee A, Buonocore MH, Simon TJ, Rogers S, Ozonoff S, Amaral DG (2011) Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders. Proceedings of the National Academy of Sciences 108:20195-20200. 

Martha E. O'Donnell, Ph.D.

Professor, Department of Physiology and Membrane Biology, UC Davis

Phone: 530-752-7626
Email: meodonnell@ucdavis.edu 

Current IDDRC Projects

  • Blood-Brain Barrier Ion Transport in Cerebral Ischemia, NIH, R01 NS39953

Assistant Professor, Department of Chemistry, UC Davis

Phone: 530-752-2595
Email: deolson@ucdavis.edu 

Current IDDRC Projects

  • Dimethyltryptamine-Levoamphetamine Hybrids as Plasticity-Promoting Treatments for Neuropsychiatric Diseases, STAIR Grant

Sally Ozonoff, Ph.D.

Endowed Professor and Vice Chair for Research, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone: 916-703-0259
Email: sozonoff@ucdavis.edu

Areas of Interest

Early Diagnosis, Autism Spectrum Disorders, Infant Development, Siblings

Research

Sally Ozonoff is the Director of the IDDRC’s Clinical Translational Core. Her research program focuses on the behavioral phenotype of very young children with or at risk for ASD and methods for earliest detection of ASD. Dr. Ozonoff is studying the onset of both ASD and ADHD in a prospective investigation that follows high-risk infants from birth through age 3. She is also studying risk factors, both biological and behavioral, for regressive patterns of onset. Another current project is focused on developing a video-based screening tool for identification of ASD in infancy.

Current IDDRC Projects

  • Development of a Prospective Video-Based Measure to Identify ASD Risk in Infancy, NIMH/NIH, R01 MH099046

  • Infants at Risk of Autism: A Longitudinal Study, NIMH/NIH, R01 MH068398

Recent Representative Publications

Shen, M.D., Nordahl, C.W., Young, G.S., Wootton-Gorges, S.L., Lee, A., Liston, S.E., Harrington, K., Ozonoff, S., & Amaral, D.G. (2013). Early brain enlargement and extra-axial fluid in infants who develop autism spectrum disorder. Brain, 136, 2825-2835.

Ozonoff, S., Young, G.S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L.J., Constantino, J.N., Dobkins, K., Hutman, T., Iverson, J.M., Landa, R., Rogers, S.J., Sigman, M., & Stone, W.L. (2011). Recurrence risk for autism spectrum disorders: A Baby Siblings Research Consortium study. Pediatrics, 128, e488-e495.

 Shumway, S., Thurm, A., Swedo, S.E., Deprey, L., Barnett, L., Amaral, D.G., Rogers, S.J., & Ozonoff, S. (2011). Symptom onset patterns and functional outcomes in young children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 41, 1727-1732.

Ozonoff, S., Iosif, A., Young, G.S., Hepburn, S., Thompson, M., Colombi, C., Cook, I.C., Werner, E., Goldring, S., Baguio, F., & Rogers, S.J. (2011). Onset patterns in autism: Correspondence between home video and parent report. Journal of the American Academy of Child and Adolescent Psychiatry, 50, 796-806.

Ozonoff, S., Iosif, A., Baguio, F., Cook, I.C., Hill, M.M., Hutman, T., Rogers, S.J., Rozga, A., Sangha, S., Sigman, M., Steinfeld, M.B., & Young, G.S. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 258-268.

Isaac N. Pessah, Ph.D.

Associate Dean of Research and Graduate Education, Professor, Department of Molecular Biosciences, UC Davis School of Veterinary Medicine
Department of Molecular Biosciences
1089 Veterinary Medicine Drive, Room 2023
Davis, California 95616


Phone: 530-752-6696 / Fax: 530-752-4698
E-mail: inpessah@ucdavis.edu 

Areas of Interest

FMR1-related disorders, Autism, Neurotoxicology, Gene X Environment Interactions

Research

Isaac Pessah is Dean of Research and Graduate Education in the School of Veterinary Medicine and was the founding Director of the UC Davis Center for Children’s Environmental Health (2001-11) and currently serves as Deputy Director. His research and teaching extend broadly in molecular and cellular pharmacology and toxicology. Currently studies include malignant hyperthermia susceptibility/central core disease conferred by mutations in RYR1 and CACNA1S, FMR1 related disorders, and Rett syndrome, using human iPSC derived neurons, mouse primary neuronal culture models and brain slices.

Current IDDRC Projects

  • Uncovering the Molecular Basis of Malignant Hyperthermia, NIH, P01 AR52354   
  • Calcium Signaling Defects in Autism, NIH, P01 ES011269

Recent Representative Publications

Pretto, D. I., Kumar, M., Cao, Z., Cunningham, C., Durbin, B., Li, H., Berman, R., Noctor, S., Hagerman, R. J., Pessah, I. N., Tassone F. (2014)  Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.  Neurobiol Aging 35,1189-1197.

Cao, Z., Hulsizer, S., Cui, Y., Pretto, D. L., Kim, K. H., Hagerman, P. J., Tassone, F., and Pessah, I. N. (2013) Enhanced asynchronous Ca2+ oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 premutation expansion. J Biol Chem 288, 13831-41. PMC3650419

Girirajan, S., Johnson, R. L., Tassone, F., Balciuniene, J., Katiyar, N., Fox, K., Baker, C., Srikanth, A., Yeoh, K. H., Khoo, S. J., Nauth, T. B., Hansen, R., Ritchie, M., Hertz-Picciotto, I., Eichler, E. E., Pessah, I. N., Selleck, S. B. (2013) Global increases in both common and rare copy number load associated with autism. Human Molec Genetics 22, 2870-80. PMC3690969

Liu, J.*, Kościelska, K. A.*, Cao, Z.*, Hulsizer, S., Grace, N., Mitchell, G., Nacey, C., Githinji, J., McGee, J., Hagerman, R. J,. Nolta, J., Pessah, I. N., Hagerman, P. J.  (2012)  Signaling defects in iPSC-derived fragile X premutation neurons. Human Molec Genetics 21, 3795-805.  *equally contributed PMC3412379

Cao, Z., Hulsizer, S., Tassone, F., Tang, H., Hagerman, R. J., Rogawski, M. A., Hagerman, P. J., and Pessah, I. N.   (2012)  Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with allopregnanolone.  Human Molec. Genetics 21, 2923-35. PMC3373240

Colin Reardon, Ph.D.

Assistant Professor and Researcher
Department of Anatomy, Physiology and Cell Biology,
School of Veterinary Medicine

Email: creardon@ucdavis.edu

Current IDDRC Projects

  • Mapping of the neuro-immune interface, NIH OT2OD023871

Sally J. Rogers, Ph.D.

Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone: 916-703-0264 / Fax: 916-703-0244
Email: sjrogers@ucdavis.edu  

Areas of Interest

Autism, Early Intervention, Early Diagnosis, Parent Training

Research

Dr. Rogers specializes in conducting developmental research into autism and other developmental disorders and working with children with developmental disabilities and their families, especially young children with autism. She studies early developmental processes, including imitation, social-communicative behavior, development of motor skills, language, and social interaction patterns. She is also involved in developing treatments for autism and examining treatment efficacy in autism using a treatment model that she developed in collaboration with Geraldine Dawson, the Early Start Denver Her clinical interests include evaluation of cognitive, behavioral, social, emotional, and adaptive functioning; early intervention for children with autism; developing treatment and educational interventions for persons with autism of all ages, and social skills groups for adults with autism. She has written extensively in her field, authoring numerous articles and books and developing training videos. Dr. Rogers serves on the editorial board of many publications.

Current IDDRC Projects

  • Adapting an Evidence-based Practice for children At-Risk for Autism for Diverse Early Intervention Service Systems, USDE R324A150211
  • Intervention effects of intensity and delivery style for toddlers with ASD, NIH R01 MH10030

Recent Representative Publications

Dawson, G., Rogers, S., Munson, J., Smith, M., Jamie, W., Greenson, J., et al. (2010). Randomized controlled trial of the Early Start Denver Model: A developmental behavioral intervention for toddlers with autism: Effects on IQ, adaptive behavior, and autism diagnosis. Pediatrics, doi/10.1542/peds.2009-0958.

Wallace, K.S., & Rogers, S.J. (2010). Intervening in infancy: Implications for autism spectrum disorders. Journal of Child Psychology and Psychiatry, 51(12), 1300-1320.

Rogers, S.J., Estes, A., Lord, C., Vismara, L., Winter, J., Fitzpatrick, A., Guo, M., & Dawson, G. (2012). Effects of a brief early start denver model (ESDM)-based parent intervention on toddlers at risk for autism spectrum disorders: A randomized controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 51(10), 1052-1065.

Dawson, G., Jones, E.J.H., Merkle, K., Venema, K., Lowy, R., Faja, S., Kamara, D., Murias, M., Greenson, J., Winter, J., Smith, M., Rogers, S.J., & Webb, S.J. (2012). Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51(11), 1150-1159.

Estes, A., Vismara, L., Mercado, C., Fitzpatrick, A., Elder, L., Greenson, J., Lord, C., Munson, J., Winter, J., Young, G., Dawson, G., & Rogers, S.J. (2014). The impact of parent-delivered intervention on parents of very young children with autism. Journal of Autism and Developmental Disorders, 44(2), 353-365.

Rebecca J. Schmidt, Ph.D.

Assistant Professor, UC Davis MIND Institute, Department of Public Health Sciences, UC Davis School of Medicine
One Shields Avenue
Davis, CA 95817



Phone: 530-752-3226 / Fax: 530-517-0026
E-mail: rjschmidt@ucdavis.edu  

Areas of Interest

Molecular Epidemiology, Autism, Neurodevelopment, Gene-Environment Interaction, Maternal Nutrition, Gestational Exposures

Research

Rebecca J. Schmidt’s research focuses on understanding how environmental exposures, primarily those occurring during gestation, interact with genetic susceptibility to influence neurodevelopmental outcomes for children. Because nutritional factors have prominent influences on gene expression and are especially important during the perinatal period, her research has largely focused on nutritional effects on neurodevelopment as they interact with the genome, including producing the first evidence for a potentially protective effect of folic acid, and a first example of gene x environment interaction in autism with one-carbon metabolism genes. She co-leads an effort to develop a semi-validated early life environmental exposure questionnaire to be used in autism studies, and is expanding research on gene-environment and nutrient-environment interactions in the context of autism, working towards identifying mechanisms potentially involved, especially those relating to epigenetics, as this field provides groundbreaking framework for these intersections.

Current IDDRC Projects

  • Folic Acid Prevention Pathways for ASD in High Risk Families, NIEHS/NIH, R01ES025574

Recent Representative Publications

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt L, Tancredi DJ, Tassone F, Hertz-Picciotto I (2011 Jul). Prenatal vitamins, functional one-carbon metabolism gene variants, and risk for autism in the CHARGE Study. Epidemiology 22(4): 476-485. Published Online, May 24, 2011. *Selected by Autism Speaks for Top Ten Science Autism Research Achievements of 2011 and recognized as a 2011 Paper of the Year by the NIEHS

Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, Hertz-Picciotto I (2012). Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 96(1):80-9. Published Online May 30, 2012. doi: 10.3945/ajcn.110.004416

Mitchell MM, Woods R, Chi L-H, Schmidt RJ, Pessah IN, Kostyniak PJ, and LaSalle JM (2012 Oct). Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environmental and Molecular Mutagenesis 53(8):589-98 Published Online, Aug 29, 2012. doi: 10.1002/em.21722.

Hertz-Picciotto I, Lyall K, Schmidt RJ (2014 Apr). Maternal Lifestyle and Environmental Risk Factors for Autism Spectrum Disorders. [Invited Review] International Journal of Epidemiology 43(2): 443-64. Published Online Feb 11, 2014. doi: 10.1093/ije/dyt282. PMID: 24518932.

Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I. “Prenatal residential proximity to agricultural pesticides is associated with autism and developmental delay in the CHARGE study.” Environ Health Perspect. Published Online Jun 23, 2014. PMID: 24954055.

Schmidt RJ, Tancredi DJ, Krakowiak P, Hansen RL, Ozonoff S. Maternal Intake of Supplemental Iron and Risk for Autism Spectrum Disorders. Am J Epidemiol

Julie B. Schweitzer, Ph.D.

Director, Attention, Impulsivity, Regulation (AIR) and ADHD Program UC Davis MIND Institute; Co-Center Mentoring Director of the MIND Institute; Co-Director, Mentored Clinical Research Training Program – CTSC, UC Davis; Director, UC Davis Schools of Health Mentoring Academy; Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine


UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone: 916-703-0294
Email: jschweitzer@ucdavis.edu

Areas of Interest

Attention Deficit Hyperactivity Disorder (ADHD), Fragile X syndrome, Autism, Substance Abuse Disorders, Attention and Learning, Lifespan

Research

Dr. Schweitzer is the co-director of the clinical and translational core of the IDDRC, Director of the ADHD Program at UC Davis MIND Institute and co-Center Mentoring Director of the MIND Institute. Dr. Schweitzer’s research program studies attention, self-control, and reward-related processes and its development in children and adults using a variety of research tools. She has experience with a number of clinical populations including attention-deficit/hyperactivity disorder (ADHD), substance use related disorders, schizophrenia, autism and Fragile X. A primary goal of her research program is to develop a more precise understanding of decision-making in self-control situations and how development and ADHD affect decision-making during adolescence and young adulthood. Other projects include developing and testing personalized treatments in neurodevelopmental disorders.

Current IDDRC Projects

  • Feasibility of Shaping Tolerance for Delayed Rewards in Impulsive 3-6 Year Olds, NICHD 1R03HD087091
  • Developmental Changes in Neural Processes Underlying Impulsivity and ADHD. NIMH/NIH, 1R01MH091068
  • Virtual Reality Attention Management Program for Improving Attention in Children, NIMH/NIH 1R61MH110043-01A1

Recent Representative Publications

Xie, Y., Dixon, J.F., Yee, O.M., Zhang, J., Chen, A., DeAngelo, S., Yellowlees, P., Hendren, R., Schweitzer, J.B. (2013)  A Preliminary Study on the Effectiveness of Videoconferencing on Teaching Parent Training Skills to Parents of Children with ADHD.  Telemedicine and e-Health. PMID:23405952. 2013Feb 13.

Mazaheri, A., Fassbender, C., Coffey-Corina, S., Hartanto, T.A. Schweitzer, J.B. & Mangun, G.R. (2013). Differential Oscillatory EEG between ADHD Subtypes and Typically Developing Adolescents. Biological Psychiatry. http://dx.doi.org/10.1016/j.biopsych.2013.08.023.

Fassbender, C., Houde, S, Silver-Balbus, S., Ballard, K., Kim, B., Rutledge, K.J., Dixon, J.F., Iosif, A.M., Schweitzer, J.B. & McClure, S.M.  (in press) The Decimal Effect: Behavioral and Neural Bases for a Novel Influence on Intertemporal Choice.  J of Cognitive Neuroscience.

Rose, E, Salmeron, B, Ross, T, Waltz, J, Schweitzer, JB, McClure, SM, Stein, E. (in press). Temporal Difference Error Prediction Signal Dysregulation in Cocaine Dependence.  Neuropsychopharmacology.

Rutledge, K.J., van den Bos, W., McClure, S.M., Schweitzer, J.B. Training cognition in ADHD: Current findings, borrowed concepts and future directions.  (2012) Neurotherapeutics. DOI: 10.1007/s13311-012-0134-9.

David J. Segal, Ph.D.

Associate Director, UC Davis Genome Center, Associate Professor, Department of Biochemistry and Molecular Medicine, Pharmacology, MIND Institute, UC Davis School of Medicine
UC Davis Genome Center
451 Health Sciences Drive
Davis, California 95616

Phone: 530-754-9134 / Fax: 530-754-9658
Email: djsegal@ucdavis.edu

Areas of Interest

Angelman Syndrome, Genome Engineering, Zinc Fingers, TALEN, CRISPR, Gene Therapy, Gene Regulation, Epigenetics, Animal Models, Induced pluripotent stem cells

Research

Almost every disease has a genetic component. Often this information is used only to determine how condemned a person is to develop disease. The Segal lab would like to use the genetic information to fix the disease. A guiding principle for our work has been to study how nature does what it does, then attempt to use that knowledge to make useful tools to improve public health, either through increased knowledge or therapeutic intervention. Projects in the Segal Lab revolve around engineering zinc finger, TALE, or CRISPR DNA-binding proteins for specific applications, such as: epigenetic therapy for Angelman and Rett Syndromes, gene therapy to create permanent disruptors of the HIV genome; and studying genetic variation and human diseases, specifically SNP functions in Coronary Artery Disease.

Current IDDRC Projects

  • FAST Integrative Research Environment (FIRE) Initiative, Found. Angelman Syndrome Therapeutics
  • MSC Delivery of An Artificial Transplantation Factor to the Brain As A Treatment for Angelman Syndrome

Recent Representative Publications

Bhakta, M.S., Henry, I.M., Ousterout, D.G., Theva Das, K., Lockwood, S.H., Meckler, J.F., Wallen, M.C., Zykovich, As, Yu, Y., Leo, H., Xu, L., Gersbach, C.A. and Segal, D.J. (2013) Highly Active Zinc-Finger Nucleases by Extended Modular Assembly, Genome Research, 23:530-538.

Meckler, J.F., Bhakta, M.S., Kim, M-S., Ovadia, R., Habrian, C.H., Zykovich, A., Yu, A., Lockwood, S.H., Morbitzer, R., Elsäesser, J., Lahaye, T., Segal, D.J., and Baldwin, E.P. (2013) Quantitative Analysis of TALE-DNA Interactions Suggests Polarity Effects, Nucleic Acids Res, 41:4118-4128.

Segal, D.J. and Meckler, J.F., (2013) Genome Engineering at the Dawn of the Golden Age, Annu. Rev. Genomics Hum. Genet, 14:135–158.

Owens, J.B., Mauro, D., Stoytchev, I., Bhakta, M.S., Kim, M.-S., Segal, D.J. and Moisyadi, S. (2013) Transcription activator like effector (TALE) directed piggyBac transposition in human cells. Nucleic Acids Res, 41:9197-9207. (PMID: 23921635)

Johnson, L.M., Du, J., Hale, C.J., Bischof, S, Feng, S., Chodavarapu, R.K., Zhong, X., Marson, G., Pellegrini, M., Segal, D.J., Patel, D.J., Jacobsen, S.E. (2014) SRA/SET domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature, doi: 10.1038/nature12931 

Jill L. Silverman, Ph.D.Assistant Adjunct Professor, Department of Psychiatry and Behavioral Sciences; University of California Davis School of Medicine
Research II
4625 2nd Avenue
Sacramento, CA 95817

Phone:  916-734-8531
E-mail:  jsilverman@ucdavis.edu

Areas of Interest

Mouse Models of Autism, mouse behavioral assays, social, cognitive

Research

Dr. Silverman’s expertise is in preclinical translational evaluation of pharmacological treatments for autism spectrum disorders. Her research focus encompasses behavioral phenotypes of autism in genetic mouse models, environmental toxin effects on rat behaviors, interpretation of rodent behavioral data, pharmacological treatment reversals in mouse models of autism and the development of complex rodent behavioral tasks of executive function. Recent publications describe her discoveries of drug treatments that reduced repetitive behaviors and improved social behavior in mouse models of autism. Dr. Silverman leads projects in the Preclinical Autism Consortium for Therapeutics and serves as overall Manager of the IDDRC Rodent Behavior Core.

Current IDDRC Projects

  • Functional Outcomes of Interactions between an ASD-Relevant Gene and Air Pollution, NIH
  • Phenotypic Characterization of Novel Models of Dup15q Syndrome, NINDS/NIH S-JSROPH
  • Behavioral and Neuroimaging Phenotypes Following Early Life Pesticide Exposure, Pilot Grant S-JSPHS01
  • Angelman Syndrome Outcome Measures in a Novel Rat Model, FAST

Recent Representative Publications

Silverman JL, Gastrell PT, Karras MN, Solomon M and Crawley JN (2014). Cognitive abilities on transitive inference using a novel touchscreen technology for mice.  Cerebral Cortex, in press.

Silverman JL, Oliver CF, Karras MN, Gastrell PT, and Crawley JN (2013) Ampakine enhancement of social interaction in the BTBR mouse model of autism. Neuropharmacology: Special Issue on Cognitive Enhancers. 64:268-82.

Silverman JL, Babineau BA, Oliver CF, Karras MN, Crawley JN (2013) Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism. Neuropharmacology: Special Issue on Neurodevelopmental Disorders, in press.

Silverman JL, Smith DG, Sukoff Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN (2012). Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.  Science Translational Medicine 4:131ra51.

Silverman JL, Turner SM, Barkan CL, Tolu SS, Saxena R, Hung AY, Sheng M, Crawley JN (2011) Sociability and motor functions in Shank1 mutant mice.  Brain Research Special Issue on The Emerging Neuroscience of Autism Spectrum Disorders, 1380: 120-137.

Tony J. Simon, Ph.D.

Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2341
Sacramento, CA 95817

Phone: 916-703-0407 / Fax: 916-703-0244
Email: tjsimon@ucdavis.edu

Areas of Interest

Chromosome 22q11.2 deletion syndrome, (22q112, VCFS. DiGeorge), Chromosomal Disorders, Cognition, Neuroimaging, Psychopathology, Anxiety

Research

Tony J. Simon is the Associate Director of the IDDRC and Director of the IDDRC NeuroBehavioral Analysis Core. Dr. Simon research is focused on how neurocognitive, emotional and environmental factors interact to modulate learning difficulties and psychopathology in neurodevelopmental disorders, particularly chromosome 22q11.2 deletion syndrome (22q11.2/VCFS/DiGeorge syndrome), fragile X syndrome, and sex chromosome aneuploidies. He also leads the 22q Healthy Minds Clinic that focuses on the mind, brain and behavior aspects of 22q11.2DS. Dr. Simon is interested in developing technology based interventions in the form of video games and internet based training that can enhance functioning, reduce symptom severity and improve quality of life. Current projects are focused on understanding the neurocognitive factors underlying learning difficulties in 22q11.2DS and related disorders and the also on understanding how cognition, emotion and environment interact to modulate stress, anxiety and psychiatric disorders in 22q11.2DS.

Current IDDRC Projects

  • Cognitive-Affective Psychosis Proneness Risk and protective factors in 22q11.2DS, NIMH/NIH
  • Translation of A Neurotherapeutic Video Games to Virtual Reality

Recent Representative Publications

Shapiro, H., Wong, L., Simon, T.J. (2013) A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome. Frontiers in Child and Neurodevelopmental Psychiatry. 4, 81. 

Angkustsiri, K., Tartaglia, N.R., Leckliter, I., Enriquez, J., Hansen, R.L., Beaton, E.A., Simon, T.J. (2012) An examination of the relationship of anxiety and intelligence to adaptive functioning of children with chromosome 22q11.2 deletion syndrome. Journal of Development and Behavioral Pediatrics. 33, 713-720 

Stoddard, J., Niendam, T., Hendren, R., Carter, C., Simon, T.J. (2010) Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. Schizophrenia Research, 118: 118-121 

Karayiourgou, M., Simon, T.J., Gogos, J.A., (2010) 22q11.2 microdeletions: Linking DNA structural variation to brain dysfunction and schizophrenia. Nature Reviews Neuroscience, 11: 402-416 

Simon, T.J. (2008) A New Account of the Neurocognitive Foundations of Impairments in Space, Time and Number Processing in Children with Chromosome 22q11.2 Deletion Syndrome. Developmental Disabilities Research Reviews. 14, 52-58.

Marjorie Solomon, Ph.D.

Professor, UC Davis MIND Institute, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2278
Sacramento, CA 95817

Phone: 916-703-0270 / Fax: 916-703-0244
Email: marsolomon@ucdavis.edu

Areas of Interest

Cognitive neuroscience of autism, Cognitive Development, Learning, fMRI, Socialization Intervention, Families

Research

My work focuses on the cognitive neuroscience of autism spectrum disorders and more specifically on the development of higher cognition (cognitive control and learning) in children, adolescents, and young adults. As a postdoctoral fellow at UC Davis, Department of Psychiatry, and the MIND Institute, I obtained a broad background in clinical assessment, and carried out research on executive functions and psychosocial intervention in older higher functioning children and adolescents with ASD under the Mentorship of Dr. Sally Ozonoff. I then received a K08 Career Development Award to work with Dr. Cameron Carter to use cognitive neuroscience methods including fMRI to study cognitive control, and reward processing in this same population. From 2010-2012, I was appointed to serve on the InterAgency Autism Coordinating Committee (IACC) by HHS Secretary, Kathleen Sebelius. I also am a licensed clinician and have been the Director of the MIND Institute Social Skills Intervention Program for over 10 years. I serve as a Faculty Mentor for both the NIH funded Interdisciplinary Autism Research Training Program (T32 MH073124) and the Building Interdisciplinary Careers in Women’s Health (BIRCWH) grants.

Current IDDRC Projects

  • The Neural Substrates of Higher-Level Learning in Autism, NIMH, R21 MH099250

Recent Representative Publications

Solomon, M., Yoon, J.H., Niendam, T.A., Ragland, J.D., Lesh, T. A., Fairbrother, W., & Carter., C.S. (in press).  The development of the neural substrates of cognitive control in adolescents with autism spectrum disorders. Biological Psychiatry.

Schriber, R.A., Robins, R.W., & Solomon, M. (in press). Personality & Self-Insight in Individuals with Autism Spectrum Disorder. Journal of Personality & Social Psychology.

Silverman, J.L., Gastrell, P.T., Karras, M.N., Solomon, M., Crawley, J.N. (in press). Cognitive abilities on transitive inference using a novel touchscreen technology for mice. Cerebral Cortex.

Hileman, C., Vismara, L.,& Solomon, M.. (in press) Measuring Changes in Social Behavior during a Social Skills Intervention for Higher-Functioning Children and Adolescents with Autism Spectrum Disorder. Journal of Autism and Development Disorders. PMID: 23239098

Miller, M., Bales, K.L.. Taylor, S. L., Yoon, J.H., Carter, C.S.. & Solomon, M. (in press). Oxytocin and vassopressin in children with autism: Autism Research. PMID:23413037

Aubyn Stahmer, Ph.D.Professor in Psychiatry and Behavioral Sciences
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone:  916-703-0254
Email:  astahmer@ucdavis.edu

Aubyn Stahmer, Ph.D.Postdoctoral Fellow in Psychiatry and Behavioral Sciences
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone:  916-703-0479
Email:  mtalbott@ucdavis.edu

Angela John Thurman, Ph.D.

Assistant Professional Researcher, Department of Psychiatry and Behavioral Sciences
UC Davis MIND Institute
2825 50th Street
Sacramento, CA 95817

Phone:  916-703-0467
E-mail:  ajthurman@ucdavis.edu 

Judy Van de Water, Ph.D.

UC Davis Center for Children’s Environmental Health, Professor, Department of Internal Medicine, UC Davis School of Medicine
451 Health Sciences Drive, Suite 6510 Genome Bldg.
Davis, California 95616



Phone: 530-752-2154 / Fax: 530-752-4669
E-mail: javandewater@ucdavis.edu 

Areas of Interest

Autism, Schizophrenia, Autoimmunity, Immune Dysregulation, Clinical Immunology

Research

Judy Van de Water is the Co- director of the IDDRC and Director of the UC Davis Center for Children’s Environmental Health. Dr. Van de Water’s research is focused broadly on the immune aspects of autism spectrum disorder as well as other neurodevelopmental disorders such as schizophrenia and fragile X syndrome. She is also interested in the relationship between immune development and neurodevelopment, especially the affects of the maternal immune environment on the development of autism.  In addition, through the Center for Children’s Environmental Health, Dr. Van de Water has a strong interest in the role of environmental exposures on immune function, and the relationship between such effects and neuronal development.   Current projects are focused on understanding the roll of immune dysregulation during gestation as well as in individuals with various neurodevelopmental disorders. More specifically, the development of immune-based biomarkers of autism risk based upon maternal autoantibodies to proteins highly expressed in the developing brain is the primary research focus of the Van de Water laboratory.

Current IDDRC Projects

  • Novel Microsystems for Manipulation and Analysis of Immune Cells, NSF EFRI -093799
  • The MARBLES (Markers of Autism Risk in Babies – Learning Early Signs) study, NIEHS/NIH 1 R01 ES020392-01
  • UC Davis Center for Children’s Environmental Health, NIEHS/NIH, 2 P01 ES011269-11; EPA Log Number  HQ-R-000
  • The CHARGE Study: Childhood Autism Risks from Genetics and the Environment
  • NIEHS/NIH 1 R01 ES015359-01
  • Generation of a Clinically Relevant Model for MAR Autism, Hearst Foundation

Recent Representative Publications

Braunschweig, D, Krakowiak, P, Duncanson, P, Boyce, R, Hansen, RL, Ashwood, P, Hertz-Picciotto, I, Pessah, IN, and Van de Water, J. (2013) Autism-Specific Maternal Autoantibodies Recognize Critical Proteins in Developing Brain. Translational Psychiatry, 3, e277; doi:10.1038/tp.2013.50.

Bauman, MD, Iosif, A-M, Ashwood, P, Braunschweig, D, Van de Water, J, and Amaral, DG (2013). Prenatal exposure of rhesus monkeys to autism-specific maternal antibodies alters brain growth and social behavior. Translational Psychiatry, 3, e278; doi:10.1038/tp.2013.47

Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I.N., and Van de Water, J. (2011) Altered T cell responses in autism. Brain Behavior and Immunity 25:840-849.

Braunschweig, D, Duncanson, P, Boyce, R, Hansen, R, Ashwood, P, Pessah . IN, Hertz-Picciotto. I, and Van de Water, J. (2012)   Behavioral correlates of maternal antibody status among children with autism. Journal of Autism and Developmental Disorders, 42:1435-1445.

Piras IS, Haapanen L, Napolioni V, Sacco R, Van de Water J, Persico AM.  (2014) Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder. Brain Behav Immun. Jan 3. pii: S0889-1591(13)00605-3. doi: 10.1016/j.bbi.2013.12.020.

Cheryl K. Walker, M.D.

Associate Research Professor, Department of Obstetrics & Gynecology, UC Davis School of Medicine

Phone:  916-734-6670
E-mail:  ckwalker@ucdavis.edu