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Department of Medical Microbiology and Immunology

Michael Syvanen, Ph.D.

University of California, Davis
One Shields Avenue
Rm 3224 Tupper Hall
Davis, California 95616
Tel: (530) 530-752-4991
Lab: (530)
FAX: (530) 752-8692
msyvanen@ucdavis.edu

Education

University of Washington, Seattle             B.S.           Chemistry
University of California, Berkeley               Ph.D.         Biochemistry
Stanford University, Dernham Postdoctoral Fellow - A.C.S.   

Member of the Graduate Groups of Microbiology

Reprints to a number of Dr. Syvanen's publications on the issue of horizontal gene transfer are available at this site: http://www.vme.net/hgt

Research Interests

Molecular genetics detoxification mechanisms in bacteria and flies; insecticide and antibiotic resistance.

Professorial Positions

1975-1981 Silas Arnold Houghton Assistant Professor of Microbiology and Molecular Genetics, Harvard Medical School

1981-1987 Associate Professor of Microbiology and Molecular Genetics, Harvard Medical School

1987-1989 Associate Professor of Medical Microbiology & Immunology, School of Medicine, University of California at Davis

1989-Present Professor of Medical Microbiology & Immunology, School of Medicine, University of California at Davis

Selected Publications

1996 Syvanen, M., Z. Zhou, J. Wharton, C. Goldsbury, A. Clark. Heterogeneity of the glutathione transferase genes encoding enzymes responsible for insecticide degradation in the housefly. J. Molec. Evol. 43:236-240.
1997 Zhou, Z. and M. Syvanen. A complex glutathione transferase gene family in the housefly Musca domestica. Molecular and General Genetics, 256:187-194.

1997 Syvanen, M. Insertion sequences and their evolutionary role. In: Bacterial Genomes, Physical Structure and Analysis , F. deBruijn, J.R. Lupski, G.M. Weinstock (eds.), Chapman-Hall, Chapter 20, pg. 213-220.
1998 Turner, K.O., M. Syvanen and S. Meizel. The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides. Journal of Andrology, 18:571-575.

1998 Syvanen, M. and C. Kado, editors, Horizontal Gene Transfer, Chapman & Hall, London. 474 pgs.

1999 Syvanen, M. Temporal patterns of land plant evolution suggest extensive polyphyly. Pp. 376-386, In: From Symbiosis to Eukaryotism-Endocytobiology VII, (eds. Wagner, E., Normann, J., Greppin, H., Hackstein, J.H.P., Herrmann, R.G., Kowallik, K.v., Schenk, H.E.A., and Seckbach, J.), Geneva University Press.

2002 Syvanen, M. and C. Kado eds  Horizontal Gene Transfer (2nd Edition), Academic Press, New York, London  445 pp. 2002  Syvanen, M. Temporal patterns of eukaryotic evolution suggest extensive polyphly. In: Horizontal Gene Transfer (2nd Edition), Academic Press, New York, London. pp 383-395.

2002 Syvanen, M. On the occurrence of horizontal gene transfer among an arbitrarily chosen group of 26 genes. Journal of Molecular Evolution. 54:258-66

2002 Syvanen M.  Rates of Ribosomal RNA Evolution Are Uniquely Accelerated in Eukaryotes.  J. Mol. Evol. 55:85-91. 2002 Syanen, M  Recent emergence of the  modern genetic code: a proposal.  Trends Genet. 18 (5): 245-8.

2003 Syvanen, M.  Churning out safer microbes for drug delivery Nat Biotechnol. 2003 Jul;21(7):758-9.

2004 Syvanen, M.  Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2106-11.
2004 Syvanen, M.  Transcription profile of Helicobacter pylori in the human stomach reflects its physiology in vivo. J Infect Dis. 2004 Sep 1;190(5):946-56.