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Department of Medical Microbiology and Immunology

Satya Dandekar, Ph.D.

UC Davis
One Shields Avenue
Rm 5511 Genome and Biomedical Sciences Building
Davis, CA 95616
Tel: (530) 752-3409
Lab: (530) 752-3542
FAX: (530) 752-7240
sdandekar@ucdavis.edu

Research interests

Dr. Satya Dandekar is a professor of Microbiology and the chairperson of the Department of Medical Microbiology and Immunology at UC Davis and has a joint appointment in the Department of Internal Medicine, Division of Infectious Diseases, School of Medicine.

Under her guidance as chair of the Department of Medical Microbiology and Immunology, Dr. Dandekar has made strengthening the Department her utmost priority and focused her efforts on faculty recruitment and building the infrastructure for the Department. She also made it a priority to strengthen the infectious disease program at UC Davis through research and education. The Department currently is the primary research base for 21 faculty members, their respective staff and students.

Dr. Dandekar's research program is focused on the molecular pathogenesis of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections with special emphasis on gastrointestinal mucosal lymphoid tissue (GALT) as a major target organ of the viral infection and as a viral reservoir.

Current studies have been focused on determining the molecular mechanisms of the disruption of gut mucosal immune system in HIV infection and restoration during anti-retroviral therapy. Her research has utilized the SIV infected rhesus macaque model to investigate the pathologic effects of viral infection on the gut mucosal immune system and function.

Dr. Dandekar's research demonstrates for the first time that gastrointestinal mucosal tissue is an early target organ of HIV and an early site for viral replication and severe CD4+ T cell depletion (Guadalupe, et al. 2003). She has successfully integrated basic and clinical studies to determine the pathogenic mechanisms of mucosal HIV infection. Dr. Dandekar's research was also one of the first to demonstrate that GALT is an early target organ for the pathogenic effects of SIV infection. Dr. Dandekar's research described for the first time the restoration kinetics of gut mucosal system during therapy and repair of the damage to gut mucosal structure and function caused by the viral infection.

Dr. Dandekar's other research focus is in understanding enteropathogenic mechanisms of HIV and SIV pathogenesis. She has been responsible for developing an SIV enteropathogenic model for the studies of HIV-associated enteropathy.

Stem cell research
Standing at the forefront of the California Stem Cell Initiative, Dr. Dandekar is developing a collaboration between experts in the fields of human embryonic stem cells, umbilical cord blood stem cells and HIV therapy to develop the ability to rebuild and restore a robust immune system in HIV infected patients that have been offered little hope of further treatment due to the ongoing battle in the development of drug-resistance HIV strains.

Collaborations with the Scripps Research Institute, Beckman Research Institute of the City of Hope, Case Western Reserve Institute and private industries ThermoGenesis Corp. and Lentigen, Inc. have led to exciting developments in this research field.

International work
Furthermore, recognizing the importance of the international AIDS research programs, Dr. Dandekar has established an international collaborative research consortium in India for AIDS research. This includes the All India Institute of Medical Sciences at New Delhi, a premier biomedical research institution and a medical school, three grass-root non-governmental organizations (NGO) from Southern India and UC Davis. Two of the NGOs are located in coastal region of Andhra Pradesh that has one of the highest incidences of HIV infection, unique endemic infections and a large rural population. Dr. Dandekar has brought together researchers from the Department of Medical Microbiology and Immunology, Division of Infectious Diseases and the Department of Public Health Sciences and researchers from Stanford University for the development of this program.

Recently, she has been instrumental in developing a multi-institutional international program on HIV research in India and has participated in training of Indian researchers through her participation in the Northern California Center for AIDS Research as the Director of the Developmental Core activities. Current efforts are aimed at developing the infrastructure and cost-effective assays relevant to Indian setting for the care and management of HIV infected patients in India. She has experience working with NGOs with extensive community outreach and the Indian government research institution.

Funding resources
Dr. Dandekar continues to maintain an outstanding track record of federal funding from governmental agencies. Current funding sources include the National Institute of Health (NIH) and Dr. Dandekar is also the Director of the Developmental Center for AIDS Research component of The North-Central California Center for AIDS Research (NCCFAR).

Dr. Dandekar is a collaborator of Dr. Richard Pollard in the California Research Center for the Biology of HIV in Minorities. Their research focuses on the study of the HIV infection in minority populations and their response to therapy and mucosal immunity. The Center will also provide pilot funding and mentoring to junior investigators through the Pilot Projects Core that is directed by Dr. Dandekar.

In addition, she is also involved in the collaborative research investigation on mucosal immunity in HIV infected patient cohorts through the Center. Dr. Dandekar is very active in evaluating the research of her peers.

This has led to a recent appointment to the NIH Director's Council of Public Representatives and is also recognized in her frequent contributions as a reviewer of many journals in her field of research such as the Journal of Virology, Blood, Journal of Experimental Medicine, American Journal of Pathology, AIDS Research and Human Retroviruses, AIDS etc.

Dr. Dandekar maintains memberships in several societies and associations; is a well-known lecturer both nationally and internationally and has been an invited speaker at a number of recognized academic institutions.

Within the UC Davis community, Dr. Dandekar is well-known as an inspiring and well-organized teacher. Dr. Dandekar has designed and implemented several new series of courses, workshops and seminars related to the following research areas: Microbiology and Immunology Research Seminar Series, DNA Microarrays and Animal Models of Infectious Diseases.

Selected publications

JJ Mattapallil, Smit-McBride ZP and Dandekar S. Gastrointestinal epithelium is an early site for increased prelance of CD34+ progenitor cells in contrast to thymus during simian immunodeficiency virus infection. Journal of Virology. 73: 4518-4523, 1999.

T. Ndolo, NK Dhillon, H Nguyen, M Guadalupe, M Mudryj and Dandekar S. Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S1 phase of the cell cycle. J. Virology. 78, 2002.

George, MD, Sumanthi S, Reay E, Gelli AC and Dandekar S. High throughput gene expression profiling indicates loss of of intestinal growth factors and cell cycle mediators during primary simian immunodeficiency virus infection. Virology. 312: 84-94, 2003.

Guadulupe ME, Reay E, Sankaran S, Prindiville T, Flamm J, McNeil A and Dandekar S. Severe CD4+T cell depletion in gut lymphoid tissue during primary HIV-1 infection and substantial delay in the restoration following HAART. Journal of Virology. 77:11718-17, 2003.

George MD, Reay E, Sankaran S, and Dandekar S. Early anti-retroviral therapy in simian immunodeficiency virus infection leads to mucosal CD4+ T cell restoration and enhanced gene expression regulating mucosal repair and regeneration. Journal of Virology. 79: 2709-2719, 2005.

Sankaran S, Guadalupe M, Reay E, George MD, Flamm J, Prindiville T, Dandekar S. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1 infected non-progressors. PNAS 2005;102(28):9860.

Ndolo T, Syvanen M, Ellison T, Dandekar S. Evolution of nef variants in gut associated lymphoid tissue of rhesus macaques during primary simian immunodeficiency virus infection. Virology 2005;43:1-11.

Libertini SJ, Robinson B, Dhillon NK, Glick D, George MD, Dandekar S, Gregg J, Sawai E, Mudryj M. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Research 2005;65:10700-10708.

Nguyen H, Sankaran S, Dandekar S. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. Virology 2006;354(1):58-68.

George MD, Verhoeven D, Smit-McBride Z, Dandekar S. Gene expression profiling of gut mucosa and mesenteric lymph nodes in simian immunodeficiency virus infected macaques with divergent disease course. Journal of Medical Primatology 2006;35:261-9.

Ndolo T, George MD, Nguyen H, Dandekar S. Expression of simian immunodeficiency virus Nef protein in CD4(+) T cells leads to a molecular profile of viral persistence and immune evasion. Virology 2006;353:374-87.

Guadalupe M, Sankaran S, George MD, Reay E, Verhoeven D, Shacklett BL, Flamm J, Wegelin J, Prindiville T, Dandekar S. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. Journal of Virology 2006;80:8236-47.