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Department of Medical Microbiology and Immunology

Department of Medical Microbiology and Immunology

Demosthenes Pappagianis, M.D., Ph.D.

Professor
Tupper Hall
Room 3145
Davis Campus
(530) 752-3391
e-mail

Recent/Current
Research Funding

Graduate Group Affiliations

Microbiology

Research Interests

Medical mycology and bacteriology; coccidioidomycosis: infections of humans, immunology-vaccines, chemotherapy, experimental pathology; epidemiology, candidiasis

Representative Publications

1998 Zimmermann, C.R., Johnson, S.M., Martens, G.W., White, A.G., Zimmer, B.L. and Pappagianis, D. Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules. Infection and Immunity, 66: 2342-2345.

1999 Pappagianis, D. Coccidioides immitis Antigen. Journal of Infectious Diseases, 180:243-244.

1999 Pappagianis, D. Coccidioidomycosis. In: "Textbook of Pediatrics" 16th Edition, R.E. Behrman, R.M. Kliegman, H.B. Jensen (Eds.) Saunders Co., Chapter 236, pp. 942-944. (Revised edition of #66)

2000 Johnson, S.M., K.M. Kerekes, C.R. Zimmermann, R.H. Williams, and D. Pappagianis. Identification and cloning of an aspartyl proteinase from Coccidioides immitis. GENE 241:213-222.

2000 Cairns, L.D. Blythe, A., Kao, D. Pappagianis, L. Kaufman, J., Kobayashi and R. Hajjeh. Outbreak of coccidioidomycosis in Washington State residents returning from Mexico. Clinical Infectious Diseases 30:61-64.

2000 Sorensen, K.N., R.A. Sobel, K.V. Clemons, D. Pappagianis, D.A. Stevens, and P.L. Williams. Comparison of fluconazole and itraconazole in a rabbit model of coccidioidal meningitis. Antimicrobial Agents and Chemotherapy. 44:1512-1517.

2005 Ampel, N. M., Nelson, D.K., Li L., Dionne, S. O., Lake, D. F., Simmons, K. A., Pappagianis, D. The mannose receptor mediates the cellular immune response in human coccidioidomycosis. Infec Immun 73(4):2554-5.

2005 Ampel, N. M., Nelson, D.K., Chavez, S., Naus, K. A., Herman, a.B., Li L., Simmons, K. A., Pappagianis, D. Preliminary evaluation of whole-blood gamma interferon release for clinical assessment of cellular immunity in patients with active coccidioidomycosis. Clin Diagn Lab Immunol., Jun:12(6):700-4.

2005 Pappagianis, D. Coccidioides immitis. In Topley & Wilson’s Microbiology and Microbial Infections, Fifth Edition, Volume 4, Medical Mycology. R. J. Hay, W. Merz, (Eds), Hodder Arnold Publishers, Inc. Chapter 28.

2007 Pappagianis, D., Coccidioidomycosis. In “Textbook of Pediatrics” 18th Edition, R. M. Kliegman, R. E. Behrman, H. B. Jensen, B. F. Stanton (Eds)Saunders Co., Chapter 237, pp. 1319 – 1322.

2007 Papagianis, D. and Coccidioidomycosis Serology Laboratory. Coccidioidomycosis in California State Correctional Institutions. Ann NY Acad Sci. 1111:103-11.

2007 Lunetta, J.M., K. A. Simmons, S. M. Johnson and D. Pappagianis. Molecular cloning and expression of a cDNNA encoding a Coccidioides posadasii 1,2-alpha-mannosidase identified in the coccidioidal T2TK by immunoproteomic methods. Ann NY Acad Sci. 1111:164-80.

2007 Johnson, S.M., K.M. Kerekes, J.M. Lunetta and D. Pappagianis. Characteristics of the protective subcellular T27K vaccine. Ann NY Acad Sci. 1111:290-300.

2007 Johnson, S.M., N. W. Lerche, D. Pappagianis, J. L. Yee, J.N. Galgiani and R. F. Hector. Safety antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis). Ann NY Acad Sci. 1111:290-300.

2007 Lunetta, J. M., K. A. Simmons, S.M. Johnson, and D. Pappagianis. Molecular cloning and expression of a cDNA encoding a Coccidioides posadasii Cu, Zn superoxide dismutase identified by proteomic analysis of the coccidioidal T27K. Ann NY Acad Sci. 1111:181-97.

2007 Pappagianis, D. Current status of serologic studies in coccidioidomycosis. Current Fungal Infection Reports 1:129-134.

2009 Barry, C.D., Stevens, D. A., Hassid, E. I., Pappagianis, D., Happs, E. L. , Sahrakar, K. A new method for the treatment of chronic fungal meningitis; continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. Amer Journal Med. Sci. 238:79-82.

2009 Stevens, D. A., Clemons, K. V., Levine, H. B., Pappagianis, D., Baron, E.J., Hamilton, J. R. Expert Opinion: What to do when there is Coccidioides exposure in a laboratory. Clinical Infectious Diseases 49:919-23.

2010 Nesbit, L., S.. M. Johnson, D. Pappagianis, and N.M. Ampel. Polyfunctional T lymphocytes are in the peripheral blood of donors naturally immune to coccidioidomycosis and are not induced by dendritic cells. Infection and Immunity 78:309-15.

2010 Kuberski, T., Herrig, J., and Pappagianis, D. False positive IgM Serology in Coccidioidomycosis. Journal of Clinical Micro 48:2047-2049.

2010 Lunetta, J. M., S.M. Johnson and D. Pappagianis. Molecular cloning, characterization and expression of two β-N-acetylhexosaminidase homologs of Coccidioides posadasii. Medical Mycology 48:744-756

Recent/Current Teaching

Teaching and Research Awards