Richard W. Michelmore, Ph.D.
Director, Genome Center
4311 GBSF
Davis Campus

Our research is focused on the comparative and functional genomics of disease resistance in plants, particularly Arabidopsis, tomato and lettuce. Our investigations of Arabidopsis involve the large-scale genomic analysis of resistance gene function and evolution in Arabidopsis as well as a comparative genomics analysis of resistance across multiple species. Our studies of disease resistance in tomato focus on structure-function analyses on the resistance gene Pto, Prf and dissection of the Pto-mediated disease resistance signaling pathway. Studies on lettuce and its pathogens includes classical studies of disease resistance, development of detailed genetic maps using molecular markers, studies on transgene expression and characterization of resistance genes at the molecular level. All of these projects are supported by the lab bioinformatics group.

Lab Page:

Cantu D, Vanzetti LS, Sumner A, Dubcovsky M, Matvienko M, Distelfeld A, Michelmore RW, Dubcovsky J. (2010) Small RNAs, DNA methylation and transposable elements in wheat. BMC Genomics. 2010 11:408.

Cui X, You N, Girke T, Michelmore R, Van Deynze A. (2010) Single feature polymorphism detection using recombinant inbred line microarray expression data. Bioinformatics. 2010 26(16):1983-9.

Argyris J, Truco MJ, Ochoa O, McHale L, Dahal P, Van Deynze A, Michelmore RW, Bradford KJ. (2010) A gene encoding an abscisic acid biosynthetic enzyme (LsNCED4) collocates with the high temperature germination locus Htg6.1 in lettuce (Lactuca sp.). Theor Appl Genet. 2010 [Epub ahead of print]

Ferrante, P., Clarke, C., Cavanaugh, K., Michelmore, R.W., Buonaurio, R., Vinatzer, B.A. (2009) Contributions of the effector gene hopQ1-1 to differences in host range between Pseudomonas syringae pv. phaseolicola and P. syringae pv. tabaci. Molecular Plant Pathology. 2009 10(6):837-42.

Caldwell KS, Michelmore RW. (2009) Arabidopsis thaliana Genes Encoding Defense Signaling and Recognition Proteins Exhibit Contrasting Evolutionary Dynamics. Genetics. 2009 Feb;181(2):671-84.

Michelmore, R., Ochoa, O., and Wong, J. (2009) Bremia lactucae and lettuce downy mildew. In: Oomycete Genetics and Genomics: Diversity, Plant and Animal Interactions, and Toolbox. S. Kamoun and K. Lamour Eds. John Wiley, NJ. 2009

Y. Luo, K. Caldwell, Wroblewski T, M.E. Wright, R.W. Michelmore. (2009) Proteolysis of a Negative Regulator of Innate Immunity Is Dependent on Resistance Genes in Tomato and Nicotiana benthamiana and Induced by Multiple Bacterial Effectors, The Plant Cell. 2009 21:2458-2472

Wroblewski T, Caldwell KS, Piskurewicz U, Cavanaugh KA, Xu H, Kozik A, Ochoa O, McHale LK, Lahre K, Jelenska J, Castillo JA, Blumenthal D, Vinatzer BA, Greenberg JT and Michelmore RW (2009) Comparative large-scale analysis of interactions between several crop species and the effector repertoires from multiple pathovars of Pseudomonas and Ralstonia. Plant Physiology. 2009 10.1104/pp.109.

McHale LK, Truco MJ, Kozik A, Wroblewski T, Ochoa OE, Lahre KA, Knapp SJ, Michelmore RW. (2009) The genomic architecture of disease resistance in lettuce. Theor Appl Genet. 2009 118(3):565-80.

Chapman MA, Hvala J, Strever J, Matvienko M, Kozik A, Michelmore RW, Tang S, Knapp SJ, Burke JM. (2009) Development, polymorphism, and cross-taxon utility of EST-SSR markers from safflower (Carthamus tinctorius L.). Theor Appl Genet. 2009 120(1):85-91.

Jeuken MJ, Zhang NW, McHale LK, Pelgrom K, den Boer E, Lindhout P, Michelmore RW, Visser RG, Niks RE. (2009) Rin4 causes hybrid necrosis and race-specific resistance in an interspecific lettuce hybrid. Plant Cell 2009 21(10):3368-3378.

Simko I, Pechenick DA, McHale LK, Truco MJ, Ochoa OE, Michelmore RW, Scheffler BE. (2009) Association mapping and marker-assisted selection of the lettuce dieback resistance gene Tvr1. BMC Plant Biol. 2009 9:135.