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Department of Medical Microbiology and Immunology

Department of Medical Microbiology and Immunology

Shirley Luckhart, Ph.D.

Professor
Tupper Hall
Room 3437
Davis Campus
(530) 754-6963
e-mail

Recent/Current
Research Funding

 

 

Graduate Group Affiliations

Microbiology

Immunology

Biochemistry and Molecular Biology

Genetics

Entomology

Research Interests

General areas of research in the laboratory include: the molecular cell biology and biochemistry of malaria parasite transmission, the functional characterization of the immunological crosstalk and cell signaling that occurs between the mosquito and the mammalian host during bloodfeeding, and the impact of endemic co-infections on malaria parasite development and transmission. Specific research projects include: the conserved signal transduction pathways involved in anti-parasite host innate immunity; systems biology and function of immune factors and cell signaling pathways that are activated between mosquitoes and their mammalian hosts at the interface of bloodfeeding; identification and functional analyses of naturally occurring genetic polymorphisms associated with malaria parasite infection; mechanistic studies of enhanced pathology of HIV and non-typhoidal Salmonella co-infection with malaria.

 

 

Representative Publications

Pakpour N, Camp L, Smithers HM, Wang B, Tu Z, Nadler SA, Luckhart S. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One. 2013 Oct 11;8(10):e76535.

Hauck ES, Antonova-Koch Y, Drexler A, Pietri J, Pakpour N, Liu D, Blacutt J, Riehle MA, Luckhart S. Overexpression of phosphatase and tensin homolog improves  fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect. 2013 Nov;15(12):775-87.

Price I, Ermentrout B, Zamora R, Wang B, Azhar N, Mi Q, Constantine G, Faeder JR, Luckhart S, Vodovotz Y. In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes. J Theor Biol. 2013 Oct 7;334:173-86.

Chau JY, Tiffany CM, Nimishakavi S, Lawrence JA, Pakpour N, Mooney JP, Lokken KL, Caughey GH, Tsolis RM, Luckhart S. Malaria-associated L-arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against nontyphoidal Salmonella bacteremia. Infect Immun. 2013 Oct;81(10):3515-26.

Naranjo-Diaz N, Rosero DA, Rua-Uribe G, Luckhart S, Correa MM. Abundance, behavior and entomological inoculation rates of anthropophilic anophelines from a primary Colombian malaria endemic area. Parasit Vectors. 2013 Mar 7;6:61.

Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E, Wong S, Price MS, Eigenheer R, Phinney BS, Pakpour N, Pietri JE, Cheung K, Georgis M, Riehle M. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog. 2013 Feb;9(2):e1003180.

Pakpour N, Akman-Anderson L, Vodovotz Y, Luckhart S. The effects of ingested mammalian blood factors on vector arthropod immunity and physiology. Microbes Infect. 2013 Mar;15(3):243-54.

Drexler A, Nuss A, Hauck E, Glennon E, Cheung K, Brown M, Luckhart S. Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi. J Exp Biol. 2013 Jan 15;216(Pt 2):208-17.

Fryxell RT, Nieman CC, Fofana A, Lee Y, Traoré SF, Cornel AJ, Luckhart S, Lanzaro GC. Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali. Malar J. 2012 Apr 27;11:133.

Pakpour N, Corby-Harris V, Green GP, Smithers HM, Cheung KW, Riehle MA, Luckhart S. Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum. Infect Immun. 2012 Jun;80(6):2141-9.

Bishara W, Sikora U, Mudanyali O, Su TW, Yaglidere O, Luckhart S, Ozcan A. Portable and cost-effective pixel super-resolution on-chip microscope for telemedicine applications. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:8207-10.

Jaramillo LM, Gutiérrez LA, Luckhart S, Conn JE, Correa MM. Molecular evidence for a single taxon, Anopheles nuneztovari s.l., from two endemic malaria regions in Colombia. Mem Inst Oswaldo Cruz. 2011 Dec;106(8):1017-23.

Horton AA, Wang B, Camp L, Price MS, Arshi A, Nagy M, Nadler SA, Faeder JR, Luckhart S. The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases. BMC Genomics. 2011 Nov 23;12:574.

Pon J, Napoli E, Luckhart S, Giulivi C. Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. Malar J. 2011 Oct 26;10:318.

Trott KA, Chau JY, Hudgens MG, Fine J, Mfalila CK, Tarara RP, Collins WE, Sullivan J, Luckhart S, Abel K. Evidence for an increased risk of transmission of simian immunodeficiency virus and malaria in a rhesus macaque coinfection model. J Virol. 2011 Nov;85(22):11655-63.

Marquez AG, Pietri JE, Smithers HM, Nuss A, Antonova Y, Drexler AL, Riehle MA, Brown MR, Luckhart S. Insulin-like peptides in the mosquito Anopheles stephensi: identification and expression in response to diet and infection with Plasmodium falciparum. Gen Comp Endocrinol. 2011 Sep 1;173(2):303-12.

Kajla MK, Shi L, Li B, Luckhart S, Li J, Paskewitz SM. A new role for an old antimicrobial: lysozyme c-1 can function to protect malaria parasites in Anopheles mosquitoes. PLoS One. 2011 May 6;6(5):e19649.

Bishara W, Sikora U, Mudanyali O, Su TW, Yaglidere O, Luckhart S, Ozcan A. Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array. Lab Chip. 2011 Apr 7;11(7):1276-9.

Cienfuegos AV, Rosero DA, Naranjo N, Luckhart S, Conn JE, Correa MM. Evaluation of a PCR-RFLP-ITS2 assay for discrimination of Anopheles species in northern and western Colombia. Acta Trop. 2011 May;118(2):128-35.

Gutiérrez LA, Orrego LM, Gómez GF, López A, Luckhart S, Conn JE, Correa MM. A new mtDNA COI gene lineage closely related to Anopheles janconnae of the Albitarsis complex in the Caribbean region of Colombia. Mem Inst Oswaldo Cruz. 2010 Dec;105(8):1019-25.

Pakpour N, Cheung KW, Souvannaseng L, Concordet JP, Luckhart S. Transfection and mutagenesis of target genes in mosquito cells by locked nucleic acid-modified oligonucleotides. J Vis Exp. 2010 Dec 26;(46).

Surachetpong W, Pakpour N, Cheung KW, Luckhart S. Reactive oxygen species-dependent cell signaling regulates the mosquito immune response to Plasmodium falciparum. Antioxid Redox Signal. 2011 Mar 15;14(6):943-55.

Corby-Harris V, Drexler A, Watkins de Jong L, Antonova Y, Pakpour N, Ziegler R, Ramberg F, Lewis EE, Brown JM, Luckhart S, Riehle MA. Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles stephensi mosquitoes. PLoS Pathog. 2010 July 15;6(7):e1001003.

Gutiérrez LA, Gómez GF, González JJ, Castro MI, Luckhart S, Conn JE, Correa MM. Microgeographic genetic variation of the malaria vector Anopheles darlingi Root (Diptera: Culicidae) from Cordoba and Antioquia, Colombia. Am J Trop Med Hyg. 2010 Jul;83(1):38-47.

Horton AA, Lee Y, Coulibaly CA, Rashbrook VK, Cornel AJ, Lanzaro GC, Luckhart S. Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection. Malar J. 2010 Jun 11;9:160.

Zhang X, Luckhart S, Tu Z, Pfeiffer DG. Analysis of Wolbachia strains associated with Conotrachelus nenuphar (Coleoptera: Curculionidae) in the Eastern United States. Environ Entomol. 2010 Apr;39(2):396-405.

Luckhart S, Lindsay SW, James AA, Scott TW. Reframing critical needs in vector biology and management of vector-borne disease. PLoS Negl Trop Dis. 2010 Feb 23;4(2):e566.

Vodovotz Y, Constantine G, Faeder J, Mi Q, Rubin J, Bartels J, Sarkar J, Squires RH Jr, Okonkwo DO, Gerlach J, Zamora R, Luckhart S, Ermentrout B, An G. Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol. 2010 Jun;32(2):181-95.

Gutiérrez LA, González JJ, Gómez GF, Castro MI, Rosero DA, Luckhart S, Conn JE, Correa MM. Species composition and natural infectivity of anthropophilic Anopheles (Diptera: Culicidae) in the states of Córdoba and Antioquia, Northwestern Colombia. Mem Inst Oswaldo Cruz. 2009 Dec;104(8):1117-24.

Roux CM, Butler BP, Chau JY, Paixao TA, Cheung KW, Santos RL, Luckhart S, Tsolis RM. Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar Typhimurium infection in mice. Infect Immun. 2010 Apr;78(4):1520-7. 
 

 

Recent/Current Teaching

 

 

Teaching and Research Awards