Dr. Hartigan-O'Connor's research focuses on development of the human immune system and interaction of that system with agents of chronic infection such as the human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Most recently he has studied development of Th17 cells, regulatory T cells (T-regs), and antigen-presenting cells in the mucosal immune system. He is interested in the relationship between variable development of such immune cells and variable control over chronic infectious diseases. He is also fascinated by the interactions between the normal gut microflora, pathogenic organisms, and immune cells within the intestine.
For more information please visit the HOC Lab page.
Hartigan-O'Connor, D.J., Poon, C., Sinclair, E., and McCune, J.M. (2006). Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 319, 41-52.
Hartigan-O'Connor, D.J., Abel, K., and McCune, J.M. (2007). Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med 204, 2679-2692.
Babik, J.M., Dohan, D., Monto, A., Hartigan-O'Connor, D.J., and McCune, J.M. (2011). The human fetal immune response to hepatitis C virus exposure in utero. J Infect Dis 203, 196-206.
Hartigan-O'Connor, D.J., Jacobson, M.A., Tan, Q.X., and Sinclair, E. (2011). Development of CMV immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis 52, 409-417.
Hartigan-O'Connor, D.J., Abel, K., VanRompay, K.K.A., Kanwar, B., and McCune, J.M. (2011). SIV replication is restricted in macaques with large Th17 cell compartments. Submitted.
Hartigan-O'Connor, D.J., del Pozo-Balado, M., Morelli, M., and McCune, J.M. (2011). Polymorphism and allelic exclusion at the macaque IL-17 locus. In preparation.