Graduate Group Affiliations
Dr. Hartigan-O'Connor's research focuses on development of the human immune
system and interaction of that system with agents of chronic infection such
as the human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Most
recently he has studied development of Th17 cells, regulatory T cells
(T-regs), and antigen-presenting cells in the mucosal immune system. He is
interested in the relationship between variable development of such immune
cells and variable control over chronic infectious diseases. He is also
fascinated by the interactions between the normal gut microflora, pathogenic
organisms, and immune cells within the intestine.
Hartigan-O'Connor, D.J., Poon, C., Sinclair, E., and McCune, J.M. (2006).
Human CD4+ regulatory T cells express lower levels of the IL-7 receptor
alpha chain (CD127), allowing consistent identification and sorting of live
cells. J Immunol Methods 319, 41-52.
Hartigan-O'Connor, D.J., Abel, K., and McCune, J.M. (2007). Suppression of
SIV-specific CD4+ T cells by infant but not adult macaque regulatory T
cells: implications for SIV disease progression. J Exp Med 204, 2679-2692.
Babik, J.M., Dohan, D., Monto, A., Hartigan-O'Connor, D.J., and McCune, J.M.
(2011). The human fetal immune response to hepatitis C virus exposure in
utero. J Infect Dis 203, 196-206.
Hartigan-O'Connor, D.J., Jacobson, M.A., Tan, Q.X., and Sinclair, E. (2011).
Development of CMV immune recovery uveitis is associated with Th17 cell
depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis
Hartigan-O'Connor, D.J., Abel, K., VanRompay, K.K.A., Kanwar, B., and
McCune, J.M. (2011). SIV replication is restricted in macaques with large
Th17 cell compartments. Submitted.
Hartigan-O'Connor, D.J., del Pozo-Balado, M., Morelli, M., and McCune, J.M.
(2011). Polymorphism and allelic exclusion at the macaque IL-17 locus. In
Teaching and Research Awards