LARRC Scholar Pilot Projects
Award Year 2014-2015
Laura Castro-Schilo, Ph.D.
Laura Castro-Schilo received her doctoral training in quantitative psychology at the University of California, Davis under the mentoring of Dr. Keith Widaman and Dr. Kevin Grimm. Prior to graduate school, Dr. Castro-Schilo graduated Summa Cum Laude with a BA in Psychology from California State University, Fullerton. She joined the L. L. Thurstone Psychometric Laboratory at the University of North Carolina at Chapel Hill as an Assistant Professor in the fall 2013. Her program of research is focused on the development and application of statistical models for analyzing short-term and long-term processes with an emphasis on psychometric issues. Dr. Castro-Schilo applies her methodological expertise to the study of life-span development of Mexican-origin individuals. She is interested in the identification of psychological, behavioral, and cultural factors that affect well-being in this population.
Project: Cognitive Health Benefits of Positive Emotions for Elder Mexican Americans
This project seeks to identify factors that deflect cognitive impairments and decline by focusing on positive psychological processes that improve mental and physical health and can be used to implement intervention programs for Mexican-origin elders. Specifically, we focus on positive emotions, the pathways by which they influence cognitive health, and their value in protecting cognitive health at old age. Positive emotions have been linked to a wealth of positive mental and physical health outcomes. Similarly, mental and physical health has been shown to predict cognitive health. This project brings together these two lines of research to investigate the role of positive emotions in the cognitive health of aging Mexican Americans. The proposed model posits positive emotions as factors influencing mental health, physical health, quality of social relationships, creativity, and mindfulness. These constructs act as mediators linking positive emotions to cognitive health. Moreover, positive emotions are also hypothesized to have direct effects on cognitive health. This study requires secondary analysis of longitudinal data from the Sacramento Area Latino Study on Aging (SALSA) and the University of California, Davis Alzheimer’s Disease Center (UCD ADC) Longitudinal Cohort study. We will use structural equation modeling and mixed modeling approaches to achieve the goals of the project. Analyses will be conducted with both datasets to allow for conceptual replication of the findings.
Luis G Carvajal Carmona, Ph.D.
Dr. Luis Carvajal-Carmona graduated with a Magda Cum Laude from the National University in Colombia, his native country, and obtained his PhD from University College London. For his PhD dissertation, he used genetic markers to show the asymmetrical patterns of founding admixture that gave origin to the Hispanic groups from Latin America. His PhD work is currently one of the most cited examples of directional mating in humans. He carried out postdoctoral Fellowships at the London Research Institute and the University of Oxford in the UK. His postdoctoral work led to the publication of several high impact papers, including the discovery of the first common locus associated with colorectal cancer risk in the general populations. During his career, Dr. Carvajal-Carmona has developed expertise on population and cancer genetics. He has published over 50 peer-reviewed publications in several highly impact journals such as Nature Genetics, Gastroenterology, PLoS Genetics and PNAS. His research efforts have been recognized with number of awards including the European Association for Cancer 40th Anniversary Research Award, the Division of Medical Sciences Research Award from the University of Oxford and, more recently, a prestigious V Foundation Scholarship. Dr. Carvajal-Carmona is currently an Assistant Professor at the University of California Davis where he leads a human and cancer genetics laboratory in the Genome Center. He leads several international research collaborative networks, including the CHIBCHA and COLUMBUS studies, two of the largest cancer genetics studies in Hispanic populations. His current research focuses on cancer genetics and epidemiology, cancer health disparities and global cancer health.
Project: Identification of Genetic Variants Influencing Cognitive Function using
a Genome-Wide Association Study
In In this project I will use a genome-wide association study (GWAS) to identify genetic variants that influence variation in cognitive phenotypes and endophenotypes in the Latino SALSA cohort. We will genotype, with genome-wide single nucleotide polymorphism (SNPs) arrays, ~400 subjects from our community based diversity SALSA cohort for whom DNA samples are available. Using this genetic data we will investigate associations between SNPs and cognitive function variables such as normal cognition, mild cognitive impairment or dementia and MRI measurements such as total intracranial volume, brain volume and gray matter volume. We will also test hypothesis related to the role of genetic admixture on these phenotypic traits.
Reymundo Lozano, M.D.
Dr. Lozano is a Pediatric Geneticist, who has dedicated his research to better understanding the molecular basis of genetic disorders associated with intellectual disabilities and autism spectrum disorders (ASD). He is an International Medical Graduate from Mexico and completed his subspecialty studies at UCLA. He specializes in the treatment of neurodevelopmental genetic syndromes including fragile X syndrome (FXS), Angelman syndrome, 15q duplication syndrome, 22q11 microdeletion syndrome, and Noonan syndrome and other RASopathies. His work focuses on different clinical trials for ASD and FXS. Dr. Lozano is dedicated to finding better treatments and eventually the cure for neurodevelopmental disorders. He is also studying the phenotypic variability of fragile X premutation carries and the additive effects of other “genetic hits” and environmental exposures. He pursues the genetic diagnosis of ASD, using cutting edge technology, including microarrays, mitochondrial function and whole exome sequencing. Dr. Lozano is an advocate for minority participation in clinical trials and his goal is to provide the necessary information to enhance enrollment and retention of minority participants. He is involved in identifying the linguistic and systemic barriers to early diagnosis and intervention commonly found in Hispanic children with ID and ASD. He is also interested in increasing diversity among medical students and faculty members at UC Davis.
Project: The aging effects differences in Latinos and Caucasians with
the premutation of FMR1 gene
Fragile X syndrome (FXS) and Fragile X-associated disorders (FADs) are related to mutations in the Fragile X Mental Retardation 1 gene. The premutation is associated with a variety of diseases and abnormal aging, including memory and cognition deficits as well as tremor and ataxia. FXTAS (fragile X-associated tremor/ataxia syndrome) is a neurodegenerative disorder that is observed in about 40% of males with the premutation. The premutation is associated with increased levels of FMR1-RNA (which leads to neurotoxicity) as well as with diminished levels of the FMRP (FMR1 encoded protein) which is responsible for cognition deficits and psychopathological disorders observed in premutation carriers. We aim to phenotype the clinical, psychological, psychiatric and molecular profiles of Latino premutation adults who we have been already identified in our GP study, and to make a comparison with Caucasian premutation adults who have been already phenotype and genotype in our GP study. We also aim to analyze the genetic admixture that could influence the phenotype differences on the Latino participants.
Award Year 2012-2014
Carolina Apesoa-Varano, Ph.D.
Ester Carolina Apesoa-Varano is an assistant professor at the Betty Irene Moore School of Nursing at UC Davis. Apesoa-Varano earned Bachelor of Arts degrees in Spanish and Latin-American Literature and Sociology at State University of New York, Oneonta, in 1997. She earned a Master of Arts in Sociology from California State University, Sacramento, in 2000 and a Doctor of Philosophy in Sociology from UC Davis in 2008. Apesoa-Varano was a Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar, part of a prestigious National Institute of Health program, from 2011 to 2012. Prior to joining the School of Nursing, she was a postdoctoral scholar in the UC Davis School of Medicine Department of Psychiatry and Behavioral Sciences where her research focused on barriers to depression care in diverse, older men’s health.
Project: Social Capital and Ethnicity: A Qualitative Longitudinal Study of Caregiving Experience,
Burden, and Reward among Alzheimer’s Disease Latina Caregivers
While the literature on caregiving and caregiver intervention is vast, we lack understanding of effective interventions to support Latina caregivers who are more likely to report high levels of burden, depression, and stress compared to other ethnic groups. The overall purpose of this pilot longitudinal qualitative study is to show how social capital and ethnicity impact Latina caregivers’ experiences and the nature of their social resources over time as they care for someone with AD. The study is a purposive, non-probability sample of Latina family caregivers of a patients with AD recruited and assessed through the UC Davis Alzheimer’s Disease Center database. Structured physical and mental health data will be collected using two questionnaires and analyzed for descriptive statistics. Qualitative interviews will be converted to text and thematically analyzed.
Lorena Garcia, Ph.D.
Lorena Garcia is an assistant professor in Public Health Sciences at the UC Davis School of Medicine. Dr. Garcia’s expertise is in chronic health, aging, endocrinology and metabolism, minority health, and health disparities.
Dr. Garcia’s current research also includes examining raw milk consumption in Mexico through funding from the UC Global Health Institute Junior Faculty Fellowship. The Raw Milk/Leche Bronca Study is a global health collaboration that will study the consumption, characteristics and views/beliefs of raw milk/leche bronca (RM/LB) in rural communities of Mexico which have high outmigration to the USA.
Dr. Garcia was formerly an Interdisciplinary Women’s Health Research (IWHR) Scholar from the NIH-sponsored BIRCWH (Building Interdisciplinary Research Careers in Women's Health) program at the UC Davis School of Medicine. Her research focused on health disparities in Mexican, White and African American women, where she looked at metabolic and nutritional syndromes, particularly obesity, pre-diabetes, diabetes and health-related complications, such as heart disease, stroke, and high blood pressure.
Dr. Garcia received a Doctor of Public Health from the Department of Epidemiology at UCLA in 2002 and a Masters of Public Health in Epidemiology/Biostatistics from Boston University in 1996. She has been engaged in Latino health research since the early 1990s with a special interest in health disparities, chronic disease, aging, behavioral health, injury and violence prevention in the Latino community.
Project: The Impact of Neighborhood Context on Older Latino’s Chronic Health Status
Older Latinos are more likely to reside in lower socioeconomic position (SEP) neighborhoods and to have negative health outcomes. Neighborhood context can positively and or negatively affect older Latino health. The prevalence of cardiovascular disease risk factors such as diabetes, obesity, and hypertension is particularly high among low SEP Latinos. While it is understood that health disparities and chronic disease exist by race and SEP, there is limited information on the specific role that neighborhood context plays on older Latino health and specifically to cardiovascular health. Therefore it is hypothesized that low neighborhood SEP will negatively impact older Latino’s chronic health, specifically their diabetes status. We plan to determine the relationship of neighborhood context on diabetes status for older Latino’s to examine the role of neighborhood context on changes in diabetes status and to assess whether these relationships differ by gender and nativity. Logistic regression methods and multilevel regression models will be used to analyze the covariates of interest.
Sarah Farias, Ph.D.
Sarah Farias is an Associate Professor in Neurology at the UC Davis. Primary research interests involve the development of new measures of everyday functioning applicable to older adults with cognitive impairment and dementia, and the study of the how cognitive and non-cognitive impairments influence everyday functioning. Other active research interests in the area of aging are related to the influence of vascular disease on cognitive decline, the role of cognitive reserve in moderating the effects of disease on cognition, and the development of new approaches for how to measure cognitive reserve in older adults. Dr. Farias obtained a bachelor’s in science degree from Arizona State University in 1993, and a PhD from the University of North Texas in 2000. She held an internship in the department of Neurology and Psychiatry at Tulane University and in 2002, and she was awarded a NIMH-funded summer research scholarship in Geriatric Psychiatry.
Project: Development of a community-based cognitive enrichment intervention to
promote cognitive health in Hispanic older adults
Convincing evidence suggests that engagement in cognitively, socially, and physically stimulating activities have positive effects on cognition. Multimodal interventions, which incorporate opportunities for learning and novelty along with increased physical and social activity, may offer the greatest benefits to brain health. One approach to providing this type of intervention is through volunteer work. We seek to understand the perceptions and barriers Latino older adults have regarding participation in intervention programs designed to maintain or improve cognitive health through volunteerism. We will conduct and analyze qualitative focus groups to (a) define Latino older adults’ views on volunteerism and activities that promote general cognitive health, (b) identify specific barriers to participating in volunteer work, and (c)identify facilitators to volunteerism. In Phase 2 we will conduct and analyze focus groups with leaders and stakeholders at community-based volunteer organizations. Data will be analyzed using qualitative methods and relying on collaborative expertise from within the UC Davis academic community.
Dawnte Early, Ph.D.
Dawnté R. Early is a postdoctoral fellow in the Department of Neurology at her alma mater. Dr.Early received her PhD in Human Development with a minor in Quantitative Psychology from the University of California, Davis. Dr.Early's major area of interest is examining how demographic and environmental factors contribute to cognitive decline in ethnically diverse older persons.
Project: Life experience modifiers of late life cognitive trajectories
Levels of brain pathology increase and cognitive function declines as we age. The trajectories of cognitive change, however, are heterogeneous and the degree of brain pathology account for only a fraction of the between-person variance in cognitive aging. While genetic factors almost certainly play an important role in moderating or mediating the effects of brain pathology on cognitive function, considerable evidence suggests that early childhood conditions and certain types of experiences over the lifespan can also play predictive or risk-elevating roles. We examine the hypothesis that experiences in childhood and middle adulthood modify cognitive function in late life by developing specific measures of life history variables associated with cognitive trajectories in late life. Using data from the UC Davis Alzheimer’s Disease Center longitudinal cohort, a sample of 400 equally represented by Latino’s, African Americans, and Caucasians, and where there is considerable heterogeneity in cognitive status, we will use the Life Experiences Activities Form (LEAF) to collect data on childhood and adult experiences. We predict (1) that childhood poverty is associated with lower late life cognitive performance and decline, (2) greater social interaction in mid-life is associated with less cognitive decline, (3) higher levels of cognitively stimulating activities in mid-life are associated with less cognitive decline, and (4) higher levels of physical activity in mid-life are associated with less cognitive decline.