Objectives

The main goals of this training program include: connecting basic and clinical science trainees, integrating basic and translational research, and providing high caliber research training.  Quality training is made possible with a combination of outstanding and energetic faculty leadership and an exceptional pool of talented trainees (graduate students, postdoctoral fellows and clinical research fellows), who share a commitment to solving major issues in cardiovascular- and vascular-related diseases.

The overall objectives of the proposed training program are as follows:

  1. Select the most qualified predoctoral/graduate students interested in cardiovascular research from the participating graduate groups: Molecular and Cellular Integrative Physiology (MCIP), Cell and Developmental Biology (CDB), Pharmacology and Toxicology (PTX), Biomedical Engineering (BME) and other Graduate Programs
  2. Select the most qualified clinical fellows and residents, who demonstrate a commitment to basic and/or translational research and to becoming physician scientists
  3. Select the most qualified postdoctoral fellows, who demonstrate a commitment to cardiovascular research, from the faculty trainers’ laboratories.

The training program offers a multidisciplinary and extensive set of graduate level courses that provide comprehensive coverage in cardiovascular topics and in-depth discussion in biostatistics, bioinformatics, bioethics and courses on responsible conduct in research. Participation in journal clubs, weekly cardiovascular research group meetings, summer courses, annual retreats and the basic and translational research learning groups will further enhance the research experiences of the trainees. The overall aims are to facilitate the professional development through required courses, as well as, active participation in oral and written scientific presentation, and career survival skills.

In summary, the training program emphasizes a special focus in membrane proteins and cardiovascular and vascular-related diseases, while remained integrated into the wider area of graduate training at UC Davis.  The program shares several resources provided by the University. The training program consists of distinct character in providing basic and translational research training for graduate students and postdoctoral/clinical fellows in the form of (1) Basic courses important for a strong background relevant to cardiovascular diseases; (2) advanced courses; (3) basic and translational learning groups, journal clubs, cardiovascular research group weekly meetings, and retreats; (4) summer school; (5) courses in bioinformatics, imaging, proteomics and metabolomics; (6) bioethics course; (7) a “Techniques for Scientific Presentation” course; (8) a “Grant & Manuscript Writing” course and; (9) career development.

 

Application Guidelines

Conditions of Award
As a trainee in this program, it will be your opportunity and responsibility to insure that this support will go towards realizing these goals, in the form of joint publications with cross-disciplinary laboratories, with the grant number cited.
 
Our training program is a full-time (one year) curriculum starting on July  1 through June 30 which include a ten-week Summer School, Directed Reading of the Literature in Fall, Winter and Spring quarter, Meet the Faculty, Translational Learning Group Meetings, Distinguished Speakers Seminar Series. We expect full participation of our trainees in all program activities.

Eligibility

  • All nominees must be citizens or permanent visa residents of the United States.
  • If funded, the students and fellows must present his/her research at the Annual Training Program Retreat and participate in the Training Program Activities. All publications must cite the training grant (T32 HL086350).
  • It is essential that the nominees be students and postdoctoral fellows who have the best potential of becoming first-rate independent Cardiovascular Research scientists. Scholastic achievement, innovation and interdisciplinary research weigh heavily in the selection.  Collaborations between laboratories and crossing traditional boundaries are also important in the selection process. Research proposal and progress are highly valued as well as excellent GRE scores and graduate level GPA.

How to Apply
A complete application consists of the following:

  • A biographical sketch or CV
  • A concise plan (1-3 pages) of proposed research or statement of research interests and a description of career goals
  • A copy of graduate and undergraduate academic records
  • Three letters of recommendation.
  • A nomination letter from faculty sponsor and sponsor’s other funding support

Applications should be sent to the individual listed below.  The deadline for applications is May 15 with a start date of July 1.

 
Dr. A. A. Knowlton or Dr. N. Chiamvimonvat
Molecular and Cellular Cardiology
GBSF 6303
One Shields Avenue, Davis, CA, 95616

aaknowlton@ucdavis.edu and nchiamvimovat@ucdavis.edu

 

Curricular Activities

  • Summer Course
  • Seminar Series

During the seminar series, all trainees and faculty trainers will have the opportunity to present their research-in-progress to the group.  We will also invite speakers from the campus whose research is of interest to the group.  In addition, we will invite distinguished speakers who are experts in the field of our research focus group on a bi-monthly basis (a total of 6 speakers per year).

  • Journal Clubs
  • Evening Dinners
  • Learning Groups
  • K30 Workshops
  • Graduate Studies Workshops

 

Leadership

Program Directors

Nipavan Chiamvimonvat, M.D.
Co-Program Director and Mentor
Department of Internal Medicine
Division of Cardiovascular Medicine

Anne A. Knowlton, M.D.
Co-Program Director and Mentor
Department of Internal Medicine
Division of Cardiovascular Medicine

 

Mentors/Trainers

Ezra A. Amsterdam, M.D., Clinical and outcome research in coronary artery disease

Lars Berglund, M.D., Ph.D., Lipoprotein metabolism

Donald Bers, Ph.D., Regulation of cardia Ca2+; signaling and excitation-contraction coupling

Sue C. Bodine, Ph.D., Regulation of skeletal and cardiac muscle mass and plasticity

Ye Chen-Izu, Ph.D., Protein structure, folding, and immunogenicity

Colleen Clancy, Ph.D., Computer modeling of drug interactions and cardia arrhythmias

Fitz-Roy E. Curry, Ph.D., Membrane transport in capillary endothelium

Sanda Despa, Ph.D., Regulation of cardia Na+/K+ pump and the control of intracellular Na+ in heart failure

Katherine W. Ferrara, Ph.D., Molecular imaging; new drug delivery technologies; multi-modality imaging of drug delivery vehicles; pharmacokinetics

Tzipora Goldkorn, Ph.D., Cell signaling and apoptosis

Aldrin Gomes, Ph.D., Roles of proteosome in cardiac hypertrophy and failure

Nobuko Hagiwara, Ph.D., Molecular genetics in cardiovascular diseases

Bruce Hammock, Ph.D., Soluble epoxide hydrolase inhibitors as anti-hypertensive and anti-inflammatory agents

Samantha Harris, Ph.D., Roles of contractile proteins in inherited cardiomyopathies and heart failure

Johannes W. Hell, Ph.D., Postsynaptic signaling mechanism and regulation of Ca channels and glutamate receptors

Leighton Izu, Ph.D., Computational modeling from ion channels to arrhythmias

John Laird, M.D., Stem cell therapy in critical limb ischemia (CLI)

Javier E. Lopez, M.D., Translational and clinical research in cardiac hypertrophy and failure

Angelique Louie, M.D., Molecular and cellular imaging

Laura Marcu, Ph.D., Novel techniques for imaging of atherosclerotic plaques

Manuel F. Navedo, Ph.D., Roles of Ca2+ in vascular dysfunction in diabetes

Martha O’Donnell, Ph.D., Functional roles of membrane transport in electrolyte homeostasis in strokes

Isaac N. Pessah, Ph.D., Structure-function of ryanodine receptor, excitation-contraction coupling

Kent E. Pinkerton, Ph.D., Air pollutions in cardiovascular function

Crystal Ripplinger, Ph.D., Mechanisms of cardiac arrhythmias

Jason H. Rogers, M.D., Clinical and outcome research in interventional cardiology

John C. Rutledge, M.D., Vascular biology

Scott Simon, Ph.D., Inflammation with focus on leukocyte-endothelial interactions in atherosclerosis

Heike Wulff, Ph.D., Drug development for targeting cardiac ion channels