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Department of Internal Medicine

Department of Internal Medicine

Nephrology Faculty Research Interests

George A. Kaysen, M.D., Ph.D

Human studies exploring the relationship between nutrition as measured by the level of serum albumin, prealbumin (transthyretin) transferrin, and body composition, inflammation and cardiovascular and overall outcomes and mortality in dialysis patients.  I am responsible for creating a biorepository for the USRDS Nutrition special study and for measuring a number of biomarkers from samples obtained in order to relate them to body composition and clinical outcomes.  My research also focuses on lipoprotein levels, structure and function as it pertains to renal disease both in humans and in experimental animal models.  These have been focuses of my research for over 20 years.

Animal studies have involved the relationship between urinary protein loss and plasma protein and lipoprotein composition.  My research has resulted in approximately 200 peer reviewed publications. 

Andrew I. Chin, M.D.

Clinical nephrology. Hemodialysis vascular access, including longitudinal changes in grafts and fistulae. Acute care hemodialysis modalities and strategies for anticoagulation in ICU dialysis. Hemodynamic and cardiovascular changes during hemodialysis.

Lorien Dalrymple, M.D., MPH

Epidemiology of acute infections in patients with kidney disease. Her research also focuses on the relation between infection, inflammation, and cardiovascular events in patients with chronic kidney disease.

Thomas A. Depner, M.D.

Biochemistry and pathogenesis of uremia including identification and measurement of potential toxins. Renal tubular transport in the diseased kidney.  Assessment of dose and adequacy of renal replacement therapy.  Mathematical modeling of hemodialysis solute kinetics.  Monitors of vascular access blood flow in hemodialyzed patients. Population studies of outcome including survival in patients with advanced kidney disease.

Current Research and Clinical Trials Programs 

Burl R. Don, M.D.

The pathophysiology of the accelerated vascular calcification and mortality in patients with chronic kidney disease (CKD) and studying potential therapies including use of specific anti-cytokine agents.  Measurement of the extra-osseous calcium burden in patients with chronic kidney disease.  Pathophysiology of the dyslipidemia in patients with CKD.

Niti Madan, M.D.

Acute kidney injury in ICU, Renal complications of cancer, Measurements of renal function, Glomerulonephritits, Cardiovascular outcomes with peritoneal dialysis.

Jose A. Morfin, M.D.

Clinical nephrology & Home Dialysis Modalities.  Hemodialysis outcomes by Ethnicity and Race.  Chronic kidney disease and prevention.

Jamie L. Ross, M.D.

Dialysis Vascular access with particular interest in clinical trials. Basic science interests would include Vascular biology and procoagulants.

Robert H. Weiss, M.D.

Molecular biology of signal transduction in vascular, kidney, and cancer cells with special emphasis on growth inhibitory mechanisms.  Role of the cyclins and cyclin inhibitors in cell growth and apoptosis, and metabolomics and proteomics of cancer and kidney disease.

Current Research

Jane Y. Yeun, M.D.

Inflammatory blockage of albumin synthesis and erythropoiesis in dialysis patients; hyperhomocysteinemia in dialysis patients; role of homocysteine in atherogenesis in dialysis patients; emphasis on clinical studies.

Brian Gallay, M.D.

Mechanisms of chronic renal allograft rejection; mechanisms of acute renal ischemia-reperfusion injury during kidney procurement for renal transplant; therapy of highly sensitized patients to decrease circulating anti-HLA antibodies and facilitate renal transplantation; development of new immunosuppression protocols for renal transplantation (steroid-avoidance and calcineurin inhibitor sparing, to name two); development of a  clinically applicable tolerance regimen for renal transplantation.

Mehul Gandhi, M.D.

Mechanisms of progression of chronic renal disease; delayed graft function.