Robert H. Weiss's Lab
We have several projects in the laboratory all relating to kidney disease and cancer. Our laboratory is uniquely situated to study the intersection between intrinsic renal disease and cancer, and is likely one of the few laboratories in this position. We have collaborations both nationally and internationally. Projects in the laboratory include but are not limited to:
- Metabolomics and proteomics analysis of kidney cancer and ADPKD for biomarker and therapeutic target discovery
- The role of the tumor suppressor proteins and p21 in renal cancer and ADPKD
- Validation of nuclear transport inhibitors and PPAR-alpha as potential cancer and kidney disease therapeutics
- Study of the tryptophan and glutamine metabolic pathways in kidney cancer
- Glycomics analysis of IgA nephropathy
- The mechanism of increased renal tumorigenesis in chronic kidney disease
- Grade dependent mechanisms and potential therapies in kidney cancer
Robert H. Weiss, MD
University of California, Santa Cruz, CA, BA, 1976
University of California, Los Angeles, CA, MS, Physical Chemistry, 1976
University of California, Los Angeles, CA, MS, Medical Physics, 1980
University of California, Irvine, CA, MD, 1984
California Pacific Medical Center, Residency, Internal Medicine, 1987
University of California, San Francisco, CA, Fellowship, Nephrology, 1991
University of California, Davis, School of Medicine, Professor of Medicine, Current
Mather (Sacramento) VAMC, Sacramento, CA, Chief, Nephrology Section, Current
Alfateh University, Tripoli Libya, DVM, 1995
Ghent University, Gent Belgium, MS, 2005
University of California, Davis, CA, MPVM, PhD, 2009-Present
University of Tripoli, Tripoli, Libya, Ved Med Student, 1989-1995
University of Tripoli, Tripoli, Libya, TA & Veterinarian, 1996-2001
University of Gent, Gent Belgium, Grad Student, 2002-2005
University of Tripoli, Tripoli, Libya, Professor, 2006-2008
University of California, Davis, ESL Student, 2008-2009
University of California, Davis, Grad Student, Current Position
Josephine Trott, Ph.D.
B.Sc.Agr, Agricultural Genetics, University of Sydney, Australia, 1995
PhD Zoology and Molecular Biology, Department of Zoology, University of Melbourne, Australia 1999
Postdoctoral Fellow: National Cancer Institute, NIH, Bethesda, MD USA 1999-2001
Postdoctoral Associate: Department of Animal Science, University of Vermont, VT, USA 2002-2005
Research Associate: Department of Animal Science, University of Vermont, VT, USA 2005-2007
Assistant Project Scientist: Department of Animal Science, UC Davis, CA, USA 2008-2013
Associate Project Scientist: Department of Animal Science and Division of Nephrology, UC Davis, CA, USA. Current Position
Current Research Projects:
- Investigating the role of tryptophan metabolism in renal cell carcinoma
- Elucidation of the enzymes involved in glutamine metabolism in renal cell carcinoma with the view to using enzyme inhibitors to decrease cancer cell proliferation
Rutgers, The State University of New Jersy, New Brunswick, NJ, BA 2010
University of California, Davis, CA, Ph.D., 2010-Present
University of California, Davis, CA, Teaching Assistant, 2011-Current
- Hwang, V., Dandekar, R., Durbin-Johnson, B., Sellier, C., Charlet Berguerand, N., Ander, B., Sharp, F., Angkustsiri, K. Simon, T., Tassone F. (2014). Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 Deletion Syndrome. Submitted.
- Hwang, V., Maar, D., Regan, J., Simon T., Tassone F. (2014). Mapping the deletion endpoints in individuals with 22q11.2 Deletion Syndrome by droplet digital PCR. Submitted.
College of William and Mary, Williamsburg, VA, BS 2008
University of Connecticut, Storrs, CT, Ph.D., 2010-2013
National Institute on Alcohol Abuse and Alcoholism, Laboratory of Molecular Signaling, NIH, Bethesda, MD, Postbaccalaureate Fellow, 2008-2009
University of Connecticut, Storrs, CT, Research Assistant, 2010-2013
University of California, Davis, CA, Postdoctoral Scholar, 2014-Present
- Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim, HY (2009). Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J. Neurochem, 111(2):510-521.
- Kim J, Li Y, Watkins BA. (2011). Endocannabinoid signaling and energy metabolism: A target for dietary intervention. Nutrition, 27(6):624-632.
- Kim J, Li Y, Watkins BA (2013). Fat to treat fat: emerging relationship between dietary PUFA, endocannabinoids, and obesity. Prost & Other Lipid Med, 104- 105:32-41.
- Kim J, Carlson M, Watkins BA (2014). Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts. Front. Physiol. In Press (5:100. doi:10.3389/fphys.2014.00100).
- Kim J, Watkins BA (2014). Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. J. Nutr Biochem. (JNB-13-648R1).
Bachelor of Science, Genetics, UC Davis (1993)
University of California, Davis, CA, Research Assistant, 1993-1998
University of California, Davis, CA, Research Technician, 1998-2004
University of California, Davis, CA, Staff Research Associate, 2004-Present
- Jeremy P.E. Spencer, Andrew Jenner, Ken Chmiel, Okezie I. Aruoma, Carroll E. Cross, Reen Wu, Barry Halliwell. DNA Damage in Human Respiratory Tract Epithelial Cells Damaged by Gas Phase Cigarette Smoke Apparently Involves Attack by Reactive Nitrogen Species in Addition to Oxygen Radicals. FEBS Letters 375 (1995) p. 179-182.
- Jeremy P.E. Spencer, Andrew Jenner, Ken Chmiel, Okezie I. Aruoma, Carroll E. Cross, Reen Wu, Barry Halliwell. DNA Strand Breakage and Base Modification Induced by Hydrogen Peroxide Treatment of Human Respiratory Tract Epithelial Cells . FEBS Letters 374 (1995) p. 233-236.
- Reen Wu, Yu Hua Zhao, Charles G. Plopper, Mary Mann-Jong Chang, Ken Chmiel, John J. Cross, Alison Weir, Jerold A. Last and Brian Tarkington. Differential Expression of Stress Protein in Nonhuman Primate Lung and Conducting Airways after Ozone. Am. J. Physiol. 277 (1999) L1-L12.
- Ken Yoneda, Konan Peck, Mary Mann-Jong Chang, Ken Chmiel, Yuh-Pyng Sher, Jeremy Chen, Pan-Chyr Yang, Yin Chen, and Reen Wu. Development of High-Density DNA Microarray Membrane for Profiling Smoke and Hydrogen Peroxide Induced Genes in a Human Bronchial Epithelial Cell Line. Am. J. Respir Crit Care Med, Vol. 164 (2001) p. S85-S89.
- Ken Yoneda, Mary Mann-Jong Chang, Ken Chmiel, Yin Chen, and Reen Wu. Application of High Density DNA Microarray to Study Smoke and Hydrogen Peroxide Induced Injury and Repair in Human Broncial Epithelial Cells. American Society of Nephrology (2002).
- Vladimir B. Serikov, Hyon Choi, Ken J. Chmiel, Reen Wu, and Jonathan H. Widdicombe. Activation of Extracellular Regulated Kinases is Required for the Increase in Airway Permeability during Leukocyte Transmigration. Am. J. Respir. Cell Mol. Biology . Vol. 30, p. 261-270 (2004).
M.B. Clinical medicine, China Medical University, Shenyang, Liaoning, 2004
M.D. Surgery, China Medical University, Shenyang, Liaoning, 2006
Ph.D. Surgery, China Medical University, Shenyang, Liaoning, 2012
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Teaching Assistant, 2006-2008
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Chief Resident, 2008-2009
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Attending Physician, 2009-2014
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Associate Professor, 2014-2015
University of California, Davis, CA, Research Associate, 2015-Present
- Xiao-nan Chen, Ke-feng Wang, Zhen-qun Xu, Shi-jie Li, Qiang Liu, Dong-hui Fu, Xia Wang and Bin Wu*. MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1. Cancer Cell International 2014, 4:70. (English)
- Xiaonan Chen, Shijie Li, Zhenqun Xu, Kefeng Wang, Donghui Fu, Qiang Liu, Xia Wang, and Bin Wu*. Clinical and oncological outcomes in Chinese patients with renal cell carcinoma and venous tumor thrombus extension: single-center experience. World J Surg Oncol. 2015; 13(1): 14. (English)
- Kefeng Wang, Xiaonan Chen, Yunhong Zhan, Weiguo Jiang, Xuefeng Liu, Xia Wang, Bin Wu*. Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma. Med Oncol, 2013, 30(2): 574-583. (English)
- CHEN Xiao-nan, Liu Yu, Jiao Hai-xin, WU Bin*. Expression and clinical significance of miR-133b in bladder urothelial carcinoma. China Journal of Modern Medicine, 2013, 23(14): 39-42. (Chinese)
- CHEN Xiao-nan, WANG Ke-feng, XU Zhen-qun, LI shi-jie, WANG Xia, WEN Ning, SONG Yong-sheng, WU Bin*. Clinical Efficacy and Experience of Transperitoneal Laparoscopic Radical Nephrectomy for 81 Cases of Large Mass Renal Cell Carcinoma. J Clin Res. 2014, 31(1): 36-38. (Chinese)
- CHEN Xiao-nan, BU Ren-ge, PAN Chun-yu, XU Zhen-qun, YANG Yu-bin, WU Bin*. Expression of Heparanase Gene in Bladder Urothelial Carcinoma and Its Clinical Significance. J Clin Res. 2012, 29(6): 1021-1023. (Chinese)
- CHEN Xiao-nan, WANG Ke-feng, XU Zhen-qun, LIU Xue-feng, WU Bin*. Report of 2 Cases of Emphysematous Cystitis and Literature Review. J Clin Res. 2013, 30(1): 11-13. (Chinese)
- WANG Kefeng, CHEN Xiaonan, ZHAN Yunhong, PAN Chunyu, LIU Xuefeng, WEN Ning, WANG Xia, WU Bin*. The Diagnosis of Fase and ECT Bone Scan in Prostate Cancer Bone Metasasis. Journal of Modern Oncology, 2013; 21(4): 802-804. (Chinese)
- Cai DW, Liu XF, Bu RG, Chen XN, Ning L, Cheng Y, Wu B*. Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population. J Int Med Res. 2009; 37(6): 1882-1889. (English)