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Department of Internal Medicine

Department of Internal Medicine

Current Research

Dr. Weiss's Lab

Robert H. Weiss's Lab

We have several projects in the laboratory all relating to kidney disease and cancer. Our laboratory is uniquely situated to study the intersection between intrinsic renal disease and cancer, and is likely one of the few laboratories in this position. We have collaborations both nationally and internationally. Projects in the laboratory include but are not limited to:

  • Metabolomics and proteomics analysis of kidney cancer and ADPKD for biomarker and therapeutic target discovery
  • The role of the tumor suppressor proteins and p21 in renal cancer and ADPKD
  • Validation of nuclear transport inhibitors and PPAR-alpha as potential cancer and kidney disease therapeutics
  • Study of the tryptophan and glutamine metabolic pathways in kidney cancer
  • Glycomics analysis of IgA nephropathy
  • The mechanism of increased renal tumorigenesis in chronic kidney disease
  • Grade dependent mechanisms and potential therapies in kidney cancer

Lab Publications Lab Publications

Dr. Weiss & Lab Personnel Information

Robert H. Weiss, MD

Robert H. Weiss, MD
Email: rhweiss@ucdavis.edu
Phone: (530) 752-3341

Education:
University of California, Santa Cruz, CA, BA, 1976
University of California, Los Angeles, CA, MS, Physical Chemistry, 1976
University of California, Los Angeles, CA, MS, Medical Physics, 1980
University of California, Irvine, CA, MD, 1984
California Pacific Medical Center, Residency, Internal Medicine, 1987
University of California, San Francisco, CA, Fellowship, Nephrology, 1991

Employment:
University of California, Davis, School of Medicine, Professor of Medicine, Current
Mather (Sacramento) VAMC, Sacramento, CA, Chief, Nephrology Section, Current

Omran Abu Aboud, Ph.D.

Omran Abu Aboud, Ph.D.
Email: oaabuaboud@ucdavis.edu
Phone: (530) 752-8868

Education:
Alfateh University, Tripoli Libya, DVM, 1995
Ghent University, Gent Belgium, MS, 2005
University of California, Davis, CA, MPVM, PhD, 2009-Present

Employment:
University of Tripoli, Tripoli, Libya, Ved Med Student, 1989-1995
University of Tripoli, Tripoli, Libya, TA & Veterinarian, 1996-2001
University of Gent, Gent Belgium, Grad Student, 2002-2005
University of Tripoli, Tripoli, Libya, Professor, 2006-2008
University of California, Davis, ESL Student, 2008-2009
University of California, Davis, Grad Student, Current Position

Publications: Omran Abu Aboud Publications

Josie Trott, Ph.D.

Josephine Trott, Ph.D.
Email: jftrott@ucdavis.edu
Phone: (530) 752-8868

Education:
B.Sc.Agr, Agricultural Genetics, University of Sydney, Australia, 1995
PhD Zoology and Molecular Biology,  Department of Zoology, University of Melbourne, Australia  1999

Employment:
Postdoctoral Fellow: National Cancer Institute, NIH, Bethesda, MD USA 1999-2001
Postdoctoral Associate: Department of Animal Science, University of Vermont, VT, USA 2002-2005
Research Associate: Department of Animal Science, University of Vermont, VT, USA 2005-2007
Assistant Project Scientist: Department of Animal Science, UC Davis, CA, USA 2008-2013
Associate Project Scientist: Department of Animal Science and Division of Nephrology, UC Davis, CA, USA. Current Position

Current Research Projects:

  • Investigating the role of tryptophan metabolism in renal cell carcinoma
  • Elucidation of the enzymes involved in glutamine metabolism in renal cell carcinoma with the view to using enzyme inhibitors to decrease cancer cell proliferation

Publications: Josie Trott's Pubs

Vicki Hwang

Vicki Hwang
Email: vhwang@ucdavis.edu
Phone: (530) 752-8868

Education: 
Rutgers, The State University of New Jersy, New Brunswick, NJ, BA 2010
University of California, Davis, CA, Ph.D., 2010-Present 

Employment: 
University of California, Davis, CA, Teaching Assistant, 2011-Current 

Publication: 

  • Hwang, V., Dandekar, R., Durbin-Johnson, B., Sellier, C., Charlet Berguerand, N., Ander, B., Sharp, F., Angkustsiri, K. Simon, T., Tassone F. (2014). Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 Deletion Syndrome. Submitted.
  • Hwang, V., Maar, D., Regan, J., Simon T., Tassone F. (2014). Mapping the deletion endpoints in individuals with 22q11.2 Deletion Syndrome by droplet digital PCR. Submitted.

Jeff Kim

Jeff Kim
Email: jefkim@ucdavis.edu
Phone: (530) 752-8868

Education:
College of William and Mary, Williamsburg, VA, BS 2008
University of Connecticut, Storrs, CT, Ph.D., 2010-2013

Employment:
National Institute on Alcohol Abuse and Alcoholism, Laboratory of Molecular Signaling, NIH, Bethesda, MD, Postbaccalaureate Fellow, 2008-2009
University of Connecticut, Storrs, CT, Research Assistant, 2010-2013 
University of California, Davis, CA, Postdoctoral Scholar, 2014-Present

Publication:

  • Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim, HY (2009). Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J. Neurochem, 111(2):510-521.
  • Kim J, Li Y, Watkins BA. (2011). Endocannabinoid signaling and energy metabolism: A target for dietary intervention. Nutrition, 27(6):624-632.
  • Kim J, Li Y, Watkins BA (2013). Fat to treat fat: emerging relationship between dietary PUFA, endocannabinoids, and obesity. Prost & Other Lipid Med, 104- 105:32-41.
  • Kim J, Carlson M, Watkins BA (2014). Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts. Front. Physiol. In Press (5:100. doi:10.3389/fphys.2014.00100).
  • Kim J, Watkins BA (2014). Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. J. Nutr Biochem. (JNB-13-648R1).

Lab Address

451 Health Sciences Drive
GBSF 6310 - 6th Floor
Davis, CA 95616 (map it)
(530) 752-3341