Dr. Weiss's Lab

Weiss Research Team

Robert H. Weiss's Lab

We have several projects in the laboratory all relating to kidney disease and cancer. Our laboratory is uniquely situated to study the intersection between intrinsic renal disease and cancer, and is likely one of the few laboratories in this position. We have collaborations both nationally and internationally. Projects in the laboratory include but are not limited to:

  • Metabolomics and proteomics analysis of kidney cancer and ADPKD for biomarker and therapeutic target discovery
  • The role of the tumor suppressor proteins and p21 in renal cancer and ADPKD
  • Validation of nuclear transport inhibitors and PPAR-alpha as potential cancer and kidney disease therapeutics
  • Study of the tryptophan and glutamine metabolic pathways in kidney cancer
  • Glycomics analysis of IgA nephropathy
  • The mechanism of increased renal tumorigenesis in chronic kidney disease
  • Grade dependent mechanisms and potential therapies in kidney cancer

Lab Publications Lab Publications

Robert H. Weiss, MD
Email: rhweiss@ucdavis.edu
Phone: 530-752-3341

Education:
University of California, Santa Cruz, CA, BA, 1976
University of California, Los Angeles, CA, MS, Physical Chemistry, 1976
University of California, Los Angeles, CA, MS, Medical Physics, 1980
University of California, Irvine, CA, MD, 1984
California Pacific Medical Center, Residency, Internal Medicine, 1987
University of California, San Francisco, CA, Fellowship, Nephrology, 1991

Employment:
University of California, Davis, School of Medicine, Professor of Medicine, Current
Mather (Sacramento) VAMC, Sacramento, CA, Chief, Nephrology Section, Current

Omran Abu Aboud, Ph.D.
Email: oaabuaboud@ucdavis.edu
Phone: 530-752-8868

Education:
Alfateh University, Tripoli Libya, DVM, 1995
Ghent University, Gent Belgium, MS, 2005
University of California, Davis, CA, MPVM, PhD, 2009-Present

Employment:
University of Tripoli, Tripoli, Libya, Ved Med Student, 1989-1995
University of Tripoli, Tripoli, Libya, TA & Veterinarian, 1996-2001
University of Gent, Gent Belgium, Grad Student, 2002-2005
University of Tripoli, Tripoli, Libya, Professor, 2006-2008
University of California, Davis, ESL Student, 2008-2009
University of California, Davis, Grad Student, Current Position

Publications: Omran Abu Aboud Publications

Josephine Trott, Ph.D.
Email: jftrott@ucdavis.edu
Phone: 530-752-8868

Education:
B.Sc.Agr, Agricultural Genetics, University of Sydney, Australia, 1995
PhD Zoology and Molecular Biology,  Department of Zoology, University of Melbourne, Australia  1999

Employment:
Postdoctoral Fellow: National Cancer Institute, NIH, Bethesda, MD USA 1999-2001
Postdoctoral Associate: Department of Animal Science, University of Vermont, VT, USA 2002-2005
Research Associate: Department of Animal Science, University of Vermont, VT, USA 2005-2007
Assistant Project Scientist: Department of Animal Science, UC Davis, CA, USA 2008-2013
Associate Project Scientist: Department of Animal Science and Division of Nephrology, UC Davis, CA, USA. Current Position

Current Research Projects:

  • Investigating the role of tryptophan metabolism in renal cell carcinoma
  • Elucidation of the enzymes involved in glutamine metabolism in renal cell carcinoma with the view to using enzyme inhibitors to decrease cancer cell proliferation

Publications: Josie Trott's Pubs

Vicki Hwang
Email: vhwang@ucdavis.edu
Phone: 530-752-8868

Education: 
Rutgers, The State University of New Jersy, New Brunswick, NJ, BA 2010
University of California, Davis, CA, Ph.D., 2010-Present 

Employment: 
University of California, Davis, CA, Teaching Assistant, 2011-Current 

Publication: 

 

  • Hwang, V., Dandekar, R., Durbin-Johnson, B., Sellier, C., Charlet Berguerand, N., Ander, B., Sharp, F., Angkustsiri, K. Simon, T., Tassone F. (2014). Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 Deletion Syndrome. Submitted.
  • Hwang, V., Maar, D., Regan, J., Simon T., Tassone F. (2014). Mapping the deletion endpoints in individuals with 22q11.2 Deletion Syndrome by droplet digital PCR. Submitted.

Kenneth Chmiel
Email: kjchmiel@ucdavis.edu 
Phone: 530-752-8868

Education:
Bachelor of Science, Genetics,  UC Davis (1993)

Employment:
University of California, Davis, CA, Research Assistant, 1993-1998
University of California, Davis, CA, Research Technician, 1998-2004 
University of California, Davis, CA, Staff Research Associate, 2004-Present

Publication:

  • Jeremy P.E. Spencer, Andrew Jenner, Ken Chmiel, Okezie I. Aruoma, Carroll E. Cross, Reen Wu, Barry Halliwell.  DNA Damage in Human Respiratory Tract Epithelial Cells Damaged by Gas Phase Cigarette Smoke Apparently Involves Attack by Reactive Nitrogen Species in Addition to Oxygen Radicals.  FEBS Letters 375 (1995) p. 179-182.
  • Jeremy P.E. Spencer, Andrew Jenner, Ken Chmiel, Okezie I. Aruoma, Carroll E. Cross, Reen Wu, Barry Halliwell.  DNA Strand Breakage and Base Modification Induced by Hydrogen Peroxide Treatment of Human Respiratory Tract Epithelial Cells .  FEBS Letters 374 (1995) p. 233-236.
  • Reen Wu, Yu Hua Zhao, Charles G. Plopper,  Mary Mann-Jong Chang, Ken Chmiel, John J. Cross, Alison Weir, Jerold A. Last and Brian Tarkington.  Differential Expression of Stress Protein in Nonhuman Primate Lung and Conducting Airways after Ozone.  Am. J. Physiol.  277  (1999) L1-L12.
  • Ken Yoneda, Konan Peck, Mary Mann-Jong Chang, Ken Chmiel, Yuh-Pyng Sher, Jeremy Chen, Pan-Chyr Yang, Yin Chen, and Reen Wu.  Development of High-Density DNA Microarray Membrane for Profiling Smoke and Hydrogen Peroxide Induced Genes in a Human Bronchial Epithelial Cell Line.  Am. J. Respir Crit Care Med,  Vol. 164 (2001) p. S85-S89.
  • Ken Yoneda, Mary Mann-Jong Chang, Ken Chmiel, Yin Chen, and Reen Wu.  Application of High Density DNA Microarray to Study Smoke and Hydrogen Peroxide Induced Injury and Repair in Human Broncial Epithelial Cells.  American Society of Nephrology  (2002).
  • Vladimir B. Serikov, Hyon Choi, Ken J. Chmiel, Reen Wu, and Jonathan H. Widdicombe.  Activation of Extracellular Regulated Kinases is Required for the Increase in Airway Permeability during Leukocyte Transmigration.  Am. J. Respir. Cell Mol.  Biology .  Vol. 30,  p. 261-270 (2004).

Xiaonan (Nathan) Chen
Email: xncchen@ucdavis.edu 
Phone: 530-752-8868

Education:
M.B. Clinical medicine, China Medical University, Shenyang, Liaoning,  2004
M.D.  Surgery, China Medical University, Shenyang, Liaoning, 2006
Ph.D.  Surgery,  China Medical University, Shenyang, Liaoning, 2012

Employment:
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Teaching Assistant, 2006-2008
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Chief Resident, 2008-2009 
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Attending Physician, 2009-2014
Shengjing Hospital of China Medical University, Shenyang, Liaoning, Associate Professor, 2014-2015
University of California, Davis, CA, Research Associate, 2015-Present

Publication:

  • Xiao-nan Chen, Ke-feng Wang, Zhen-qun Xu, Shi-jie Li, Qiang Liu, Dong-hui Fu, Xia Wang and Bin Wu*. MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1. Cancer Cell International 2014, 4:70. (English)
  • Xiaonan Chen, Shijie Li, Zhenqun Xu, Kefeng Wang, Donghui Fu, Qiang Liu, Xia Wang, and Bin Wu*. Clinical and oncological outcomes in Chinese patients with renal cell carcinoma and venous tumor thrombus extension: single-center experience. World J Surg Oncol. 2015; 13(1): 14. (English)
  • Kefeng Wang, Xiaonan Chen, Yunhong Zhan, Weiguo Jiang, Xuefeng Liu, Xia Wang, Bin 
Wu*. Increased expression of ALDH1A1 protein is associated with poor prognosis in clear 
cell renal cell carcinoma. Med Oncol, 2013, 30(2): 574-583. (English)
  • CHEN Xiao-nan, Liu Yu, Jiao Hai-xin, WU Bin*. Expression and clinical significance of miR-133b in bladder urothelial carcinoma. China Journal of Modern Medicine, 2013, 23(14): 39-42. (Chinese)
  • CHEN Xiao-nan, WANG Ke-feng, XU Zhen-qun, LI shi-jie, WANG Xia, WEN Ning, SONG Yong-sheng, WU Bin*. Clinical Efficacy and Experience of Transperitoneal Laparoscopic Radical Nephrectomy for 81 Cases of Large Mass Renal Cell Carcinoma. J Clin Res. 2014, 31(1): 36-38. (Chinese)
  • CHEN Xiao-nan, BU Ren-ge, PAN Chun-yu, XU Zhen-qun, YANG Yu-bin, WU Bin*. Expression of Heparanase Gene in Bladder Urothelial Carcinoma and Its Clinical Significance. J Clin Res. 2012, 29(6): 1021-1023. (Chinese)
  • CHEN Xiao-nan, WANG Ke-feng, XU Zhen-qun, LIU Xue-feng, WU Bin*. Report of 2 Cases of Emphysematous Cystitis and Literature Review. J Clin Res. 2013, 30(1): 11-13. (Chinese)
  • WANG Kefeng, CHEN Xiaonan, ZHAN Yunhong, PAN Chunyu, LIU Xuefeng, WEN Ning, WANG Xia, WU Bin*. The Diagnosis of Fase and ECT Bone Scan in Prostate Cancer Bone Metasasis. Journal of Modern Oncology, 2013; 21(4): 802-804. (Chinese)
  • Cai DW, Liu XF, Bu RG, Chen XN, Ning L, Cheng Y, Wu B*. Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population. J Int Med Res. 2009; 37(6): 1882-1889. (English)

Jean Chen
Email: jchchen@ucdavis.edu

Education:
China Medical University, Taiwan, BS Nursing 2000
China Medical University, Taiwan, BS Chinese Pharmaceutical Sciences 2002
China Medical University, Taiwan, MS 2004
National Chung Hsing University, Taiwan, Ph.D., 2004-20011
National Taiwan University, Taiwan, PostDoc, 2011-2012
University of California, Davis, Davis, CA, PostDoc, 2012-2016

Employment:
Center of Genomic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Postdoctoral Scholar, 2011-2012
University of California, Davis (UCD), Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, in Davis, CA, Postdoctoral Scholar, 2012-Present

Publication:

  • Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJW (2008). Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther, 7: 3527-38. PMID: 19001436 (PMCID: Exempt) (IF: 6.1)
  • Chen CH, Lin H, Chuang SM, Lin SY, Chen JJW (2010). Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. Exp Cell Res, 316:2910-21. PMID: 20615403 (PMCID: Exempt) (IF: 3.4)
  • Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC (2011). Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbio., 11:50. PMID: 213854000. PMCID: PMC3060850 (IF: 3.0)
  • Chen CH, Yang MF, Liao JW, Yu SL, Chen JJW (2012). A Novel Function of YWHAZ/β-catenin Axis in Promoting Epithelial-Mesenchymal Transition and Lung Cancer Metastasis. Mol Cancer Res., 10(10):1319-31. PMID: 22912335 (IF: 4.5)
  • Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R (2013). Characterization of a Novel Long Non-Coding RNA, SCAL1, Induced by Cigarette Smoke and Elevated in Lung Cancer Cell Lines. Am J Respir Cell Mol Biol., 49(2):204-11. PMID: 23672216 (PMCID: In Process) (IF: 4.1)
  • Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH (2013). Deletion of ATG5 Shows a Role of Autophagy in Salivary Homeostatic Control. J Dent Res., 92(10):911-7. PMID: 23884556 (PMCID: In Process) (IF: 4.1)
  • Chen CH, Thai P, Yoneda K, Adler KB, Yang PC and Wu R (2013). A peptide that inhibits function of Myristoylated Alanine - Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene,10; 33(28):3696-706. PMID: 23955080 (PMCID: In Process) (IF: 8.56) **Selected for Featured Publication
  • Chen CH, Chiu CL, Adler KB and Wu R (2014). A novel predictor of cancer malignancy: Up-regulation of MARCKS phosphorylation in lung cancer. Am. J. Respir. Crit. Care Medicine, 189(8):1002-4. PMID: 24735036 (PMCID: In Process) (IF: 11.99)
  • Chen CC, Chen HY, Su K Y, Hong QS, Yan BS, Chen CH, Pan YL, Wang CJ, Hung PF, Yuan SS, Chang GH, Chen JJW, Yang PC, Yang YC, and Yu SL (2014). Shisa3 associated with prolonged survival through promoting β-catenin degradation. Am. J. Respir. Crit. Care Medicine, 190(4): 433-444. PMID: 25036006 (PMCID: In Process) (IF: 11.99)
  • Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, and Wu R (2014). Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am. J. Respir. Crit. Care Medicine, 190(10):1127-38. PMID: 25318062 (PMCID: In Process) (IF: 11.99) **Special editorial commentary on article in issue
  • Tseng YT, Li W, Chen CH, Zhang S, Chen JJ, Zhou XJ and Liu CC (2015). IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics, 16 Suppl 2:S10. PMID: 25707505 (IF: 4.0)
  • Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R and Ann DK (2015). Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget, 20;6(17):15194-208 (IF: 6.6)
  • Chen CH, Chang WH, Su KY, Hong QS, Chen HC, Wu R, Yang PC, Chen JJW, Yu SL (2015). HLJ1 is an endogenous Src inhibitor that suppresses cancer progression through dual mechanisms. Oncogene, Revision.

Lab Address

451 Health Sciences Drive
GBSF 6310 - 6th Floor
Davis, CA 95616 (map it)
530-752-3341