Clinical/Research Interests

Dr. Duleba's primary clinical interests are related to polycystic ovary syndrome (PCOS), endometriosis, chronic pelvic pain and minimally invasive surgery, including procedures such as hysteroscopy and endometrial ablation for abnormal uterine bleeding. In addition, he is interested in providing clinical care to patients with a broad range of reproductive-endocrine problems, including infertility and uterine fibroids. Dr. Duleba's research activities include ovarian function, and in particular, evaluation of mechanisms regulating growth and steroidogenesis of ovarian mesenchyme. Additionally, he is pursuing a project on the effects of the mevalonate pathway in the growth of endometrial stroma. Dr. Duleba's clinical studies involve women with polycystic ovary syndrome, especially the role of oxidative stress and inflammation.

Philosophy of Care:

Dr. Duleba's clinical care is focused on patients' satisfaction and safety.

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Select Recent Publications:

Diamanti-Kandarakis E, Piperi C, Papavassiliou AG, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Duleba AJ. Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol, 2007 Jan 5. [Epub ahead of print]

Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ. Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: Prospective randomized cross-over trial. J Clin Endocrinol Metabol, 92:456-61, 2007. [Epub 2006 Nov 14]

Piotrowski PC, Kwintkiewicz J, Rzepczynska IJ, Seval Y, Cakmak H, Arici A, Duleba AJ. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biol Reprod, 75:107-11, 2006.

Kwintkiewicz J, Spaczynski RZ, Foyouzi N, Pehlivan T, Duleba AJ. Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways: Akt and Erk1/2 converge on p70S6-kinase. Biol Reprod, 74:1034-40, 2006.

Kwintkiewicz J, Foyouzi N, Piotrowski P, Rzepczynska I, Duleba AJ. Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. Fertil Steril, 86:1053-8, 2006.

Duleba AJ, Banaszewska B, Spaczynski RZ, Pawelczyk L. Simvastatin improves endocrine and metabolic aspects of polycystic ovary syndrome: Results of prospective randomized trial. Fertil Steril, 85:996-1001, 2006.

Banaszewska B, Duleba AJ, Spaczynski RZ, Pawelczyk L. Lipids in polycystic ovary syndrome: Role of hyperinsulinemia and effects of metformin. Am J Obstet Gynecol, 194:1266-72, 2006.

Spaczynski RZ, Tilly JL, Mansour A, Duleba AJ. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Mol Hum Reprod, 11:319-24, 2005.

Spaczynski RZ, Pawelczyk L, Duleba AJ. Leptin does not modulate basal or IGF-I induced proliferation and steroidogenesis of ovarian theca-interstitial cells. Pol J Gyn Invest, 8:70-4, 2005.

Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman H. Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress. Hum Reprod, 19:1519-24, 2004.