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Department of Dermatology

Department of Dermatology

Dr. Zhao Research Lab

Min Zhao, M.D., Ph.D.

Professor

Dr Zhao

Dermatology & Ophthalmology Research
Institute for Regenerative Cures
School of Medicine, UC Davis
2921 Stockton Blvd, Suite 1600
Sacramento, CA 95817
minzhao@ucdavis.edu
Tel: 916-703-9381 
Fax: 916-703-9384 

 

 

Biography

Dr. Min Zhao is a professor of dermatology at the UC Davis School of Medicine. He is also an honorary professor at the University of Aberdeen, Cardiff University and a guest professor at the 3rd Military Medical University, China.

Wonderful as are the laws and phenomena of electricity when made evident to us in inorganic or dead matter, their interest can bear scarcely and comparison with that which attaches to the same force when connected with the nervous system and with life.

                 Michael Faraday 1839

Dr. Zhao was born in the Yunnan Province of China. He graduated from the 3rd Military Medical University in Chongqing in 1985. After completion of Ph.D. training under the supervision of Professor Zhengguo Wang in 1991, he worked on trauma research at the Research Institute of Surgery. In 1994 he joined Dr Geff Burnstock in 1994 at University College, London. He then moved to the University of Aberdeen as a research fellow to work with Professors Colin McCaig and John Forrester. At Aberdeen he won a Wellcome Trust University Award Lectureship in 1999 and was promoted to a Wellcome Trust University Award Senior Lectureship in 2002. Then in 2004 he was promoted to Professor/Personal Chair in Biomedical Science and Regenerative Medicine. His group discovered that PI3 kinase/Pten molecules are key elements in the electric signaling (Nature 2006; 442, 457-460). In 2007, he moved to UC Davis and is currently a Professor of Dermatology and he also holds a joint appointment in Ophthalmology.

 

Lab Members

Dr Zhao Research Lab Team 

 

Dr Zhao 

Min Zhao, M.D., Ph.D. 
Professor
Research interests: Control of directed cell motility and directed cell division, the role played by small physiological electrical fields in wound healing, the development and regeneration of many tissues.

Address: 2921 Stockton Blvd, Suite 1600
Sacramento, CA 95817
Email: minzhao@ucdavis.edu
Phone: 916-703-9381

Brian Reid 

Brian Reid
Brian Reid graduated from the University of Aberdeen, Scotland with a BSc in Microbiology. He then went on complete a PhD studying electrotaxis of zoosporic fungi. Following his PhD, he worked on vesicle recycling in retinal bipolar cells at the MRC Laboratory of Molecular Biology in Cambridge, England and later worked on the specificity of nerve-muscle interaction with Dr. Guy Bewick. He joined the laboratory of Min Zhao in 2001. Brian’s projects include:

  1. Electric fields and wound healing in human and rat cornea.
  2. Role of electric fields and ion flux in Xenopus frog tadpole tail regeneration.
  3. Wound healing in primate airway epithelium.
  4. Electrical activity in brain after traumatic injury.
  5. Feather bud development.

Email: brireid@ucdavis.edu
Tel: 916-703-9382

Lin Cao 

Lin Cao 
Lin Cao was awarded a first class BSc degree in Science of Medicine from the Fourth Military Medical University, Xi’an, China in 1986, and a PhD from the University of Aberdeen for his studies of molecular mechanisms of chemoresistance in solid tumors. Dr. Cao has research interests in:

  1. Electric field controlling neuron stem cell migration in vitro and in vivo.
  2. The molecular and cellular mechanisms controlling cell polarity.
  3. High throughput screening for electrotaxis mechanisms.
  4. Mechanism and regulation of transepithelium potential.

Email: lincao@ucdavis.edu
Tel: 916-703-9380

Jiaping Zhang 

Jiaping Zhang 
Dr. Zhang received his MSc and PhD in Burn Surgery at the Research Institute of Burns, 3rd Military Medical University in Chongqing, China. He is interested in regenerative medicine and wound healing. He is now leading a project on the control of directed stem cell migration.

Email: japzhang@yahoo.co.cn 
Tel: 530-703-9380

Yaho-Hui Sun 

Yao-Hui Sun 
Dr. Sun is interested in the molecular mechanisms of electric field (EF) effects on cell polarization, cell migration and tissue regeneration. He uses combined genetic, bio-physical and bio-chemical approaches, and RNAi technology. He is currently using high throughput screening methods, developed in the lab, to understand how cells sense applied EFs. He is also working on the role of PI3K and PTEN signaling in cell migration in a 3D culture model.

Email: yhsun@ucdavis.edu 
Tel: 916-703-9383

Qunli Zeng 

Qunli Zeng 
Qunli Zeng was awarded a BSc degree from Nankai University, Tianjin, China in 1991 and a PhD degree from Zhejiang University, Hangzhou, China. Dr. Zeng’s research focuses on the bioeffects and molecular mechanisms of environmental electromagnetic fields (EMF) on cells. She has found that EMF can inhibit intercellular communication through gap junctions, induce DNA double-strand breakage, change cell periphery and evoke reorganizations in microfilament cytoskeleton. She has also used proteomics to investigate changes in protein profiles induced by EMF in cells.

Email: yhsun@ucdavis.edu 
Tel: 916-703-9380

Vu Tran 

Vu Tran 
Vu Tran has been a student member of the lab since December 2007. Vu’s current research interests include working with a synchronization-modulation stimulator to excite relatively non-excitable cells and potentially enhance epithelial wound healing.

Email: vutran087@gmail.com

 

Ben Lee 
Ben Lee is a student member of the lab.  His research interests include synchronization-modulation to stimulate membrane ion pumps and hyperpolarize Xenopus oocytes.

Email: belee@ucdavis.edu

 

Run-Chi Gao 
Jr. Specialist.

Email: runchigao@163.com

 

Jinfeng Feng 
Email: jffeng@ucdavis.edu

 

Chuan Cao 
Email: cnccao@yahoo.com

 

Lei Zhang, Ph.D. 
Email: zlepo@yahoo.com.cn

 

Entong Wang, M.D., Ph.D. 
Email: Wang-entong@hotmail.com

 

Laura Chalmers, Ph.D. 
Email: Laurachalmers107@btinternet.com 

 

 

Research

Zhao Lab - Electric fields, regeneration and wound healing 

Our research is aimed toward improving wound healing and regeneration of damaged or diseased tissues.

Our current work focuses on:

  1. The role naturally occurring electric fields or electric currents in wound healing and tissue regeneration.
  2. Development of therapies to electrically stimulate and direct wound healing and tissue regeneration.
  3. Targeting stem cell migration.

 

Publications

  1. Tai G, Reid B, Cao L, Zhao M. Electrotaxis and Wound Healing: Experimental Methods to Study Electric Fields as a Directional Signal for Cell Migration. Methods Mol Biol. 2009, 571:77-97.
  2. Zhao M. Electrical fields in wound healing – an overriding signal that directs cell migration. Semin Cell Dev Biol. 2009;20(6):674-82.
  3. Reid B, Song B, Zhao M. Electric currents in Xenopus tadpole tail regeneration. Dev Biol. 2009 335(1):198-207.
  4. Kloth L, Zhao M. Endogenous and Exogenous Electrical Fields for Wound Healing. In Wound Healing: Evidence-Based Management. Ed.J McCulloch and L Kloth. 4th Edition. F.A. Davis. Brick, NJ. 2009.
  5. Yao L, McCaig C, Zhao M. Electrical signals polarize neuronal organelles, direct neuron migration and orient cell division. Hippocampus. 2009, 19(9):855-68.
  6. Li Y, Shanley L, McCaig CD, Zhao M. Electric field directed neuronal migration. J Cell Physiol. 2008; 216:527-35.
  7. Zhao Z, Walczysko P, Zhao M. Intracellular calcium store is essential for injury induced calcium signaling and re-endothelialization. J Cell Physiol. 2008; 214:595-603.
  8. Zhao M. PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol. 2007;152:1141-4.
  9. Song B, Gu Y, Pu J, Reid B, Zhao Z, Zhao M. Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo. Nat Protoc. 2007;2:1479-89.
  10. Reid B, Nuccitelli R, Zhao M. Non-invasive measurement of bioelectric currents with a vibrating probe. Nat Protoc. 2007;2 (3):661-9.
  11. Pu J, McCaig CD, Cao L, Zhao Z, Segall JE, Zhao M. EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. J Cell Sci. 2007;120:3395-403.
  12. Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM. Electrical signals control wound healing via PI3Kg and PTEN signalling. Nature, 2006. 442, 457-460.
  13. Shanley L, Walczysko P, Bain M, McEvan D, Zhao M. Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium. J Cell Sci. 2006, 119(Pt 22):4741-8.
  14. McCaig CD, Rajnicek AM, Song B, Zhao, M. Controlling cell behavior electrically: current views and future potential for an old concept. Physiol Review 2005; 85: 943-78.
  15. Pu J, Zhao M. Golgi polarization in a strong electric field. J Cell Sci. 2005; 118:1117-1128.
  16. Wang E, Reid B, Lois N, Forrester JV, McCaig C, Zhao M. Electrical inhibition of lens epithelial cell proliferation – An additional factor in secondary cataract? FASEB J. 2005; 19: 842-4.
  17. Reid B, Song B, McCaig CD, Zhao M. Wound healing in rat cornea: the role of electric currents. FASEB J. 2005; 19: 379-386.

Movies

Movie 1

 

Movie 2