1.The Use of One-Bead One-Compound Combinatorial Library Technology to Discover High-Affinity {alpha}v{beta}3 Integrin and Cancer Targeting Arginine-Glycine-Aspartic Acid Ligands with a Built-in Handle.
Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS.
Mol Cancer Ther. 2010 Sep 21. [Epub ahead of print]PMID: 20858725

2. Direct Binding of the EGF-like Domain of Neuregulin-1 to Integrins ({alpha}v{beta}3 and {alpha}6{beta}4) Is Involved in Neuregulin-1/ErbB Signaling.
Ieguchi K, Fujita M, Ma Z, Davari P, Taniguchi Y, Sekiguchi K, Wang B, Takada YK, Takada Y.
J Biol Chem. 2010 Oct 8;285(41):31388-98.

3. A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.
Yamaji S, Saegusa J, Ieguchi K, Fujita M, Takada YK, Takada Y.
PLoS One. 2010 Apr 21;5(4):e10273.PMID: 20422052

4. A T cell-binding fragment of fibrinogen can prevent autoimmunity.
Takada Y, Ono Y, Saegusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodriquez R, Takada Y, Maverakis E.
J Autoimmun. 2010 Jun;34(4):453-9. Epub 2009 Dec 24.PMID: 20036106

5. The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y.
J Biol Chem. 2009 Sep 4;284(36):24106-14. Epub 2009 Jul 3.PMID: 19578119

6. Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism.
Guo M, Daines D, Tang J, Shen Q, Perrin RM, Takada Y, Yuan SY, Wu MH.
Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):394-400. Epub 2009 Jan 2.PMID: 19122172

7. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.
Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS.
J Med Chem. 2009 Jan 8;52(1):126-33.PMID: 19055415

8. Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada YK, Takada Y.
J Biol Chem. 2008 Sep 19;283(38):26107-15. Epub 2008 Jul 17.PMID: 18635536

9. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y.
J Biol Chem. 2008 Jun 27;283(26):18066-75. Epub 2008 Apr 25.PMID: 18441324

10. Inhibition of tissue factor signaling suppresses tumor growth.
Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W.
Blood. 2008 Jan 1;111(1):190-9. Epub 2007 Sep 27.PMID: 17901245

11. The integrins.
Takada Y, Ye X, Simon S.
Genome Biol. 2007;8(5):215. Review.PMID: 17543136

12. Rotavirus-neutralizing antibodies inhibit virus binding to integrins alpha 2 beta 1 and alpha 4 beta 1.
Fleming FE, Graham KL, Taniguchi K, Takada Y, Coulson BS.
Arch Virol. 2007;152(6):1087-101. Epub 2007 Feb 23.PMID: 17318737

13. The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
Akakura N, Hoogland C, Takada YK, Saegusa J, Ye X, Liu FT, Cheung AT, Takada Y.
Cancer Res. 2006 Oct 1;66(19):9691-7.PMID: 17018627

14. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.
Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS.
Nat Chem Biol. 2006 Jul;2(7):381-9. Epub 2006 Jun 11.PMID: 16767086

15. Rotavirus spike protein VP5* binds alpha2beta1 integrin on the cell surface and competes with virus for cell binding and infectivity.
Graham KL, Takada Y, Coulson BS.
J Gen Virol. 2006 May;87(Pt 5):1275-83.PMID: 16603530

16. Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation.
Tarui T, Akakura N, Majumdar M, Andronicos N, Takagi J, Mazar AP, Bdeir K, Kuo A, Yarovoi SV, Cines DB, Takada Y.
Thromb Haemost. 2006 Mar;95(3):524-34.PMID: 16525582

17. Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family.
Wu PL, Lee SC, Chuang CC, Mori S, Akakura N, Wu WG, Takada Y.
J Biol Chem. 2006 Mar 24;281(12):7937-45. Epub 2006 Jan 10.PMID: 16407244

18. Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands.
Graham KL, Fleming FE, Halasz P, Hewish MJ, Nagesha HS, Holmes IH, Takada Y, Coulson BS.
J Gen Virol. 2005 Dec;86(Pt 12):3397-408.PMID: 16298987

19. ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
Thodeti CK, Fröhlich C, Nielsen CK, Takada Y, Fässler R, Albrechtsen R, Wewer UM.
FEBS Lett. 2005 Oct 24;579(25):5589-95. Epub 2005 Sep 28.PMID: 16213489