Department of Dermatology

Department of Dermatology

Dr. Liu Research Lab-Publications

Sano, H., Hsu, D.K., Yu, L., Apgar, J.R. Kuwabara, I., Yamanaka, T., Hirashima, M., Liu, F.-T. Human galectin-3 is a novel chemoattractant for monocytes and macrophages. J Immunol 165:2156-2164, 2000.

Hsu, D.K., Yang, R.-Y., Pan, Z., Yu, L., Salomon, D.R., Fung-Leung W.-P., and Liu, F.-T. Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol. 156:1073-1083, 2000.

Zuberi, R.I., Apgar,J.R., Chen, S.-S. and Liu, F.-T. A role for IgE in airway secretions: IgE immune complexes are more potent inducers than antigen alone of airway inflammation in a murine model. J Immunol. 164:2667-2673, 2000.

Yang, R.-Y., Hsu, D.K., Yu, L., Ni, J., and Liu, F.-T. Cell cycle regulation by galectin-12, a new member of the galectin superfamily. J Biol Chem 276:20252-20261, 2001.

Kuwabara, I., Kuwabara, Y., Yang, R.-Y., Schuler, M., Green, D.R., Hsu, D.K., and Liu, F.-T. Galectin-7 (PIG1:p53-induced gene 1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J. Biol. Chem. 277:3487-3497, 2002.

Liu, F.-T., Patterson, R.J., and Wang, J.L. Intracellular functions of galectins. Biochim Biophys Acta 1572:263-273, 2002.

Mayr, S.I, Zuberi, R.I., Zhang, M., de Sousa-Hitzler, J., Ngo, K., Kuwabara, Y., Yu, L., Fung-Leung, W.-P., and Liu, F.-T. IgE-dependent mast cell activation potentiates airway responses in murine asthma models. J. Immunol. 169:2061-8, 2002.

Sano, H., Hsu, D.K., Apgar,J.R., Yu, L., Sharma, B.B., Kuwabara, I., Izui, S., and Liu, F.-T. Critical role of galectin-3 in phagocytosis by macrophages. J. Clin. Invest. 112:389-97. 2003.

Yang, R.Y., Hsu, D.K., Yu, L., Chen, H.-Y., and Liu, F.-T. Galectin-12 is Required for Adipogenic Signaling and Adipocyte Differentiation. J. Biol. Chem. 279:29761-6, 2004.

Ueda, S., Kuwabara, I. and Liu, F.-T. Suppressive effect of galectin-7 on tumor growth. Cancer Research, 64:5672-6, 2004.

Zuberi, R. Hsu, D.K., Kalayci, O., Chen, H.-Y., Sheldon, H.K., Yu, L., Apgar, J., Kawakami, T., Lilly, C.M., and Liu, F.-T. Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. Am J Path, 165:2045-53, 2004.

Liu, F.-T. and Rabinovich, G.A. Galectins as novel modulators of tumor progression. Nature Reviews Cancer, 5:29-41, 2005.

Bernardes, E.S., Silva, N.M., Mineo, J.R., Loyola, A.M., Hsu, D.K., Liu, F.-T., Chammas, R., and Roque-Barreira, M.C. Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response. Am J Pathol 168:1910-20, 2006.

Chen, H.-Y., Sharma, B.B, Yu, L., Zuberi, R., Weng, I.-C., Kawakami, Y., Kawakami, T., Hsu, D.K., and Liu, F.-T. Role of galectin-3 in mast cell functions. Galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J Immunol 177:4991-7, 2006.

Rabinovich, G.A., Liu, F.-T., Hirashima, M., and Anderson, A. An emerging role for galectins in tuning the inflammatory response: Lessons from experimental models of autoimmunity and cancer. Scand J Immunol 66:143-58, 2007.

Saegusa, J., Hsu, D.K., Liu, W., Kuwabara, I., Kuwabara, Y., Yu, L., and Liu, F.-T. Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation. J Invest Dermatol. 128:2403-11, 2008.

Yang, R.-Y., Rabinovich, G.A., Liu, F.-T. Galectins: Structures, functions and therapeutic potential. Exp Rev Mol Med. 10:e17, 2008.

Hsu, D.K., Chen, H.-Y., Yu, L., Chernyavsky, A.I., Grando, S.A., and Liu, F.-T. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol, 129:573-83, 2009.

Saegusa, J., Hsu, D.K., Chen, H.-Y., Yu, L., Fermin, A., Fung, M.A., and Liu, F.-T. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol 174:922-931, 2009.

Hsu, D.K., Chen, H.-Y., and Liu, F.-T. Galectin-3 regulates T cells. Immunol Rev 230: 114-127, 2009.

Chen, H-Y., Fermin, A., Vardhana, S., Weng, I-C., Lo, K.F.R., Chang, E-Y., Maverakis, E., Yang, R.Y., Hsu, D.K., Dustin, M., and Liu, F.-T. Galectin-3 negatively regulates TCR-mediated CD4+ T cell activation at the immunological synapse. Proc Natl Acad Sci USA in press, 2009.

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