Department of Dermatology

Department of Dermatology

Dr. Isseroff Research Lab-Publications

  1. Lev-Tov, H., Li, C., Dahle, S., Isseroff RR. (2013). Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial. Trials. 14(8).
  2. Dasu MR, Rivkah Isseroff R. (2012). Toll-like receptors in wound healing: location, accessibility, and timing. J Invest Dermatol. 132(8):1955-8. PubMed PMID: 22797299
  3. Isseroff RR, Dahle S. Electrical Stimulation Therapy and Wound Healing: Where Are We Now? Adv Wound Care, Mar 2012, epub ahead of print.
  4. Chahal DS, Sivamani RK, Rivkah Isseroff R, Dasu MR. Plant-Based Modulation of Toll-like Receptors: An Emerging Therapeutic Model. Phytother Res. 2012 Nov 12. Epub ahead of print
  5. Rizzo, A.E., Beckett, L.A., Baier, B.S., and Isseroff, R.R. (2012). The linear excisional wound: an improved model for human ex vivo wound epithelialization studies. Skin Res Technol 18, 125-132.
  6. Pullar, C.E., Le Provost, G.S., O'Leary, A.P., Evans, S.E., Baier, B.S., and Isseroff, R.R. (2012). beta2AR Antagonists and beta2AR Gene Deletion Both Promote Skin Wound Repair Processes. J Invest Dermatol 132, 2076-2084.
  7. Liu, W., Hsu, D.K., Chen, H.Y., Yang, R.Y., Carraway, K.L., 3rd: , Isseroff, R.R., and Liu, F.T. (2012). Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration. J Invest Dermatol.
  8. Dasu, M.R., Ramirez, S., and Isseroff, R.R. (2012). Toll-like receptors and diabetes: a therapeutic perspective. Clin Sci (Lond) 122, 203-214.
  9. Steenhuis, P., Huntley, R.E., Gurenko, Z., Yin, L., Dale, B.A., Fazel, N., and Isseroff, R.R. (2011). Adrenergic signaling in human oral keratinocytes and wound repair. J Dent Res 90, 186-192.
  10. Sivamani, R.K., Schwartz, M.P., Anseth, K.S., and Isseroff, R.R. (2011). Keratinocyte proximity and contact can play a significant role in determining mesenchymal stem cell fate in human tissue. FASEB J 25, 122-131.
  11. Liu, Y.C., Margolis, D.J., and Isseroff, R.R. (2011). Does inflammation have a role in the pathogenesis of venous ulcers? A critical review of the evidence. J Invest Dermatol 131, 818-827.
  12. Fitzmaurice, S.D., Sivamani, R.K., and Isseroff, R.R. (2011). Antioxidant therapies for wound healing: a clinical guide to currently commercially available products. Skin Pharmacol Physiol 24, 113-126.
  13. Zhao, M., Penninger, J., and Isseroff, R.R. (2010). Electrical Activation of Wound-Healing Pathways. Adv Skin Wound Care 1, 567-573.
  14. Lulevich, V., Yang, H.Y., Isseroff, R.R., and Liu, G.Y. (2010). Single cell mechanics of keratinocyte cells. Ultramicroscopy 110, 1435-1442.
  15. Isseroff, R.R., and Gomez, E.C. (2010). Vincent Azubike Ziboh (1929-2009). J Invest Dermatol 130, 1489-1490.
  16. Dasu, M.R., Thangappan, R.K., Bourgette, A., DiPietro, L.A., Isseroff, R., and Jialal, I. (2010). TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice. Lab Invest 90, 1628-1636.
  17. Sivamani, R.K., Pullar, C.E., Manabat-Hidalgo, C.G., Rocke, D.M., Carlsen, R.C., Greenhalgh, D.G., and Isseroff, R.R. (2009). Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers. PLoS Med 6, e12.
  18. Sivamani, R.K., Porter, S.M., and Isseroff, R.R. (2009). An epinephrine-dependent mechanism for the control of UV-induced pigmentation. J Invest Dermatol 129, 784-787.
  19. Lewkowitz-Shpuntoff, H.M., Wen, M.C., Singh, A., Brenner, N., Gambino, R., Pernodet, N., Isseroff, R., Rafailovich, M., and Sokolov, J. (2009). The effect of organo clay and adsorbed FeO(3) nanoparticles on cells cultured on Ethylene Vinyl Acetate substrates and fibers. Biomaterials 30, 8-18.
  20. Shi, B., Grahn, J.C., Reilly, D.A., Dizon, T.C., and Isseroff, R.R. (2008). Responses of the 27-kDa heat shock protein to UVB irradiation in human epidermal melanocytes. Exp Dermatol 17, 108-114.
  21. Pullar, C.E., Manabat-Hidalgo, C.G., Bolaji, R.S., and Isseroff, R.R. (2008). beta-Adrenergic receptor modulation of wound repair. Pharmacol Res 58, 158-164.
  22. Mori, S., Wu, C.Y., Yamaji, S., Saegusa, J., Shi, B., Ma, Z., Kuwabara, Y., Lam, K.S., Isseroff, R.R., Takada, Y.K., et al. (2008). Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem 283, 18066-18075.
  23. Kurzrock, E.A., Lieu, D.K., Degraffenried, L.A., Chan, C.W., and Isseroff, R.R. (2008). Label-retaining cells of the bladder: candidate urothelial stem cells. Am J Physiol Renal Physiol 294, F1415-1421.
  24. Kim, M.H., Liu, W., Borjesson, D.L., Curry, F.R., Miller, L.S., Cheung, A.L., Liu, F.T., Isseroff, R.R., and Simon, S.I. (2008). Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J Invest Dermatol 128, 1812-1820.
  25. Ghoghawala, S.Y., Mannis, M.J., Pullar, C.E., Rosenblatt, M.I., and Isseroff, R.R. (2008). Beta2-adrenergic receptor signaling mediates corneal epithelial wound repair. Invest Ophthalmol Vis Sci 49, 1857-1863.
  26. Sivamani, R.K., Lam, S.T., and Isseroff, R.R. (2007). Beta adrenergic receptors in keratinocytes. Dermatol Clin 25, 643-653, x.
  27. Sivamani, R.K., Garcia, M.S., and Isseroff, R.R. (2007). Wound re-epithelialization: modulating keratinocyte migration in wound healing. Front Biosci 12, 2849-2868.
  28. Pullar, C.E., Zhao, M., Song, B., Pu, J., Reid, B., Ghoghawala, S., McCaig, C., and Isseroff, R.R. (2007). Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epithelium. J Cell Physiol 211, 261-272.
  29. Nguyen, M.M., Lieu, D.K., deGraffenried, L.A., Isseroff, R.R., and Kurzrock, E.A. (2007). Urothelial progenitor cells: regional differences in the rat bladder. Cell Prolif 40, 157-165.
  30. Margolis, D.J., Hoffstad, O., and Isseroff, R.R. (2007). Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers. Arch Dermatol 143, 1275-1280.
  31. Lieu, D.K., Degraffenried, L.A., Isseroff, R.R., and Kurzrock, E.A. (2007). Beta1 integrin expression pattern in transitional urothelium does not allow for efficient stem cell enrichment as in other epithelia. Tissue Eng 13, 263-270.
  32. Ghoghawala, S.Y., Mannis, M.J., Murphy, C.J., Rosenblatt, M.I., and Isseroff, R.R. (2007). Economical LED based, real-time, in vivo imaging of murine corneal wound healing. Exp Eye Res 84, 1031-1038.
  33. Sun, Y., Frenkel, A.I., Isseroff, R., Shonbrun, C., Forman, M., Shin, K., Koga, T., White, H., Zhang, L., Zhu, Y., et al. (2006). Characterization of palladium nanoparticles by using X-ray reflectivity, EXAFS, and electron microscopy. Langmuir 22, 807-816.
  34. Shi, B., and Isseroff, R.R. (2006). Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27). J Cell Physiol 206, 301-308.
  35. Shi, B., Han, B., Schwab, I.R., and Isseroff, R.R. (2006). UVB irradiation-induced changes in the 27-kd heat shock protein (HSP27) in human corneal epithelial cells. Cornea 25, 948-955.
  36. Pullar, C.E., Rizzo, A., and Isseroff, R.R. (2006). beta-Adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis. J Biol Chem 281, 21225-21235.
  37. Pullar, C.E., and Isseroff, R.R. (2006). The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms. J Cell Sci 119, 592-602.
  38. Pullar, C.E., Grahn, J.C., Liu, W., and Isseroff, R.R. (2006). Beta2-adrenergic receptor activation delays wound healing. FASEB J 20, 76-86.
  39. Pullar, C.E., Baier, B.S., Kariya, Y., Russell, A.J., Horst, B.A., Marinkovich, M.P., and Isseroff, R.R. (2006). beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell 17, 4925-4935.
  40. Mukerjee, E.V., Isseroff, R.R., Nuccitelli, R., Collins, S.D., and Smith, R.L. (2006). Microneedle array for measuring wound generated electric fields. Conf Proc IEEE Eng Med Biol Soc 1, 4326-4328.
  41. Stipcevic, T., Piljac, T., and Isseroff, R.R. (2005). Di-rhamnolipid from Pseudomonas aeruginosa displays differential effects on human keratinocyte and fibroblast cultures. J Dermatol Sci 40, 141-143.
  42. Shirakawa, M., and Isseroff, R.R. (2005). Topical negative pressure devices: use for enhancement of healing chronic wounds. Arch Dermatol 141, 1449-1453.
  43. Shi, B., and Isseroff, R.R. (2005). Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes. Exp Dermatol 14, 519-527.
  44. Salehi-Had, H., Alvarenga, L.S., Isseroff, R., and Schwab, I.R. (2005). Factors modulating p63 expression in cultured limbal epithelial cells. Cornea 24, 845-852.
  45. Pullar, C.E., and Isseroff, R.R. (2005). Cyclic AMP mediates keratinocyte directional migration in an electric field. J Cell Sci 118, 2023-2034.
  46. Pullar, C.E., and Isseroff, R.R. (2005). Beta 2-adrenergic receptor activation delays dermal fibroblast-mediated contraction of collagen gels via a cAMP-dependent mechanism. Wound Repair Regen 13, 405-411.
  47. Kurzrock, E.A., Lieu, D.K., deGraffenried, L.A., and Isseroff, R.R. (2005). Rat urothelium: improved techniques for serial cultivation, expansion, freezing and reconstitution onto acellular matrix. J Urol 173, 281-285.
  48. Kang, S.H., Fung, M.A., Gandour-Edwards, R., Reilly, D., Dizon, T., Grahn, J., and Isseroff, R.R. (2004). Heat shock protein 27 is expressed in normal and malignant human melanocytes in vivo. J Cutan Pathol 31, 665-671.
  49. Ionides, E.L., Fang, K.S., Isseroff, R.R., and Oster, G.F. (2004). Stochastic models for cell motion and taxis. J Math Biol 48, 23-37.
  50. Grahn, J.C., and Isseroff, R.R. (2004). Human melanocytes do not express EGF receptors. J Invest Dermatol 123, 244-246.
  51. Sillman, A.L., Quang, D.M., Farboud, B., Fang, K.S., Nuccitelli, R., and Isseroff, R.R. (2003). Human dermal fibroblasts do not exhibit directional migration on collagen I in direct-current electric fields of physiological strength. Exp Dermatol 12, 396-402.
  52. Shi, B., Isseroff, R.R., and Nuccitelli, R. (2003). Power line frequency electromagnetic fields do not increase the rate of protein synthesis in human skin fibroblasts as previously reported. Bioelectromagnetics 24, 465-472.
  53. Shi, B., Farboud, B., Nuccitelli, R., and Isseroff, R.R. (2003). Power-line frequency electromagnetic fields do not induce changes in phosphorylation, localization, or expression of the 27-kilodalton heat shock protein in human keratinocytes. Environ Health Perspect 111, 281-288.
  54. Pullar, C.E., Chen, J., and Isseroff, R.R. (2003). PP2A activation by beta2-adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration. J Biol Chem 278, 22555-22562.
  55. Ojingwa, J.C., and Isseroff, R.R. (2003). Electrical stimulation of wound healing. J Invest Dermatol 121, 1-12.
  56. Grahn, J.C., Reilly, D.A., Nuccitelli, R.L., and Isseroff, R.R. (2003). Melanocytes do not migrate directionally in physiological DC electric fields. Wound Repair Regen 11, 64-70.
  57. Trollinger, D.R., Isseroff, R.R., and Nuccitelli, R. (2002). Calcium channel blockers inhibit galvanotaxis in human keratinocytes. J Cell Physiol 193, 1-9.
  58. Han, B., Schwab, I.R., Madsen, T.K., and Isseroff, R.R. (2002). A fibrin-based bioengineered ocular surface with human corneal epithelial stem cells. Cornea 21, 505-510.
  59. Chen, J., Hoffman, B.B., and Isseroff, R.R. (2002). Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism. J Invest Dermatol 119, 1261-1268.
  60. Pullar, C.E., Isseroff, R.R., and Nuccitelli, R. (2001). Cyclic AMP-dependent protein kinase A plays a role in the directed migration of human keratinocytes in a DC electric field. Cell Motil Cytoskeleton 50, 207-217.
  61. deGraffenried, L.A., and Isseroff, R.R. (2001). Wound dressings alter the colony-forming efficiency of keratinocytes in cultured sheet grafts. Cell Transplant 10, 749-754.
  62. Wong, J.W., Shi, B., Farboud, B., McClaren, M., Shibamoto, T., Cross, C.E., and Isseroff, R.R. (2000). Ultraviolet B-mediated phosphorylation of the small heat shock protein HSP27 in human keratinocytes. J Invest Dermatol 115, 427-434.
  63. Shi, B., and Isseroff, R.R. (2000). Divergent responses of ras-transfected and non-ras-transfected human keratinocytes to extracellular calcium. Biochem Cell Biol 78, 469-476.
  64. Schwab, I.R., Reyes, M., and Isseroff, R.R. (2000). Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease(1). Am J Ophthalmol 130, 543-544.
  65. Schwab, I.R., and Isseroff, R.R. (2000). Bioengineered corneas--the promise and the challenge. N Engl J Med 343, 136-138.
  66. Farboud, B., Nuccitelli, R., Schwab, I.R., and Isseroff, R.R. (2000). DC electric fields induce rapid directional migration in cultured human corneal epithelial cells. Exp Eye Res 70, 667-673.
  67. Obedencio, G.P., Nuccitelli, R., and Isseroff, R.R. (1999). Involucrin-positive keratinocytes demonstrate decreased migration speed but sustained directional migration in a DC electric field. J Invest Dermatol 113, 851-855.
  68. Fang, K.S., Ionides, E., Oster, G., Nuccitelli, R., and Isseroff, R.R. (1999). Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields. J Cell Sci 112 ( Pt 12), 1967-1978.
  69. Fang, K.S., Farboud, B., Nuccitelli, R., and Isseroff, R.R. (1998). Migration of human keratinocytes in electric fields requires growth factors and extracellular calcium. J Invest Dermatol 111, 751-756.
  70. Shi, B., and Isseroff, R.R. (1997). Intracellular calcium oscillations in cell populations of ras-transfected I-7 subline of human HaCaT keratinocytes. J Invest Dermatol 109, 765-769.
  71. Shi, B., and Isseroff, R.R. (1996). Thapsigargin induces phosphorylation of the 27-kDa heat shock protein in human keratinocytes. J Invest Dermatol 107, 749-754.
  72. Sheridan, D.M., Isseroff, R.R., and Nuccitelli, R. (1996). Imposition of a physiologic DC electric field alters the migratory response of human keratinocytes on extracellular matrix molecules. J Invest Dermatol 106, 642-646.
  73. Nishimura, K.Y., Isseroff, R.R., and Nuccitelli, R. (1996). Human keratinocytes migrate to the negative pole in direct current electric fields comparable to those measured in mammalian wounds. J Cell Sci 109 ( Pt 1), 199-207.

 

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