Yoshikazu Takada, M.D., Ph.D.

Yohsikazu Takada's laboratory is located in the Research III building on the Medical Center campus in Sacramento.

*         Nobuaki Akakura – Postgraduate Researcher

Publications:

Dorfleutner, A., E. Hintermann, T. Tarui, Y. Takada, and W. Ruf. 2004. Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell 15:4416.

Kamata, T., H. Ambo, W. Puzon-McLaughlin, K. K. Tieu, M. Handa, Y. Ikeda, and Y. Takada. 2004. Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit. Biochem J 378:1079.

Tarui, T., N. Andronicos, R. P. Czekay, A. P. Mazar, K. Bdeir, G. C. Parry, A. Kuo, D. J. Loskutoff, D. B. Cines, and Y. Takada. 2003. Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. J Biol Chem 278:29863.

Tarui, T., M. Majumdar, L. A. Miles, W. Ruf, and Y. Takada. 2002. Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin. J Biol Chem 277:33564.

Eto, K., C. Huet, T. Tarui, S. Kupriyanov, H. Z. Liu, W. Puzon-McLaughlin, X. P. Zhang, D. Sheppard, E. Engvall, and Y. Takada. 2002. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem 277:17804.

Kamata, T., K. K. Tieu, T. Tarui, W. Puzon-McLaughlin, N. Hogg, and Y. Takada. 2002. The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol 168:2296.

Kamata, T., K. K. Tieu, A. Irie, T. A. Springer, and Y. Takada. 2001. Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model. J Biol Chem 276:44275.

Tarui, T., L. A. Miles, and Y. Takada. 2001. Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells. J Biol Chem 276:39562.

Tarui, T., A. P. Mazar, D. B. Cines, and Y. Takada. 2001. Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem 276:3983.

Eto, K., W. Puzon-McLaughlin, D. Sheppard, A. Sehara-Fujisawa, X. P. Zhang, and Y. Takada. 2000. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem 275:34922.

Yokoyama, K., H. P. Erickson, Y. Ikeda, and Y. Takada. 2000. Identification of amino acid sequences in fibrinogen gamma -chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3. J Biol Chem 275:16891.

Puzon-McLaughlin, W., T. Kamata, and Y. Takada. 2000. Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3). J Biol Chem 275:7795.

Zhang, X. P., W. Puzon-McLaughlin, A. Irie, N. Kovach, N. L. Prokopishyn, S. Laferte, K. Takeuchi, T. Tsuji, and Y. Takada. 1999. Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3. Biochemistry 38:14424.

Kamata, T., R. C. Liddington, and Y. Takada. 1999. Interaction between collagen and the alpha(2) I-domain of integrin alpha(2)beta(1). Critical role of conserved residues in the metal ion-dependent adhesion site (MIDAS) region. J Biol Chem 274:32108.

Yokoyama, K., X. P. Zhang, L. Medved, and Y. Takada. 1999. Specific binding of integrin alpha v beta 3 to the fibrinogen gamma and alpha E chain C-terminal domains. Biochemistry 38:5872.

Meredith, J. E., Jr., W. B. Kiosses, Y. Takada, and M. A. Schwartz. 1999. Mutational analysis of cell cycle inhibition by integrin beta1C. J Biol Chem 274:8111.

Zhang, X. P., T. Kamata, K. Yokoyama, W. Puzon-McLaughlin, and Y. Takada. 1998. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. J Biol Chem 273:7345.

Takada, Y., T. Kamata, A. Irie, W. Puzon-McLaughlin, and X. P. Zhang. 1997. Structural basis of integrin-mediated signal transduction. Matrix Biol 16:143.

Takagi, J., T. Kamata, J. Meredith, W. Puzon-McLaughlin, and Y. Takada. 1997. Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem 272:19794.

Irie, A., T. Kamata, and Y. Takada. 1997. Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1. Proc Natl Acad Sci U S A 94:7198.

Irie, A., T. Kamata, and Y. Takada. 1997. [Molecular mechanisms of integrin-ligand interaction]. Tanpakushitsu Kakusan Koso 42:1679.