Education ProgramsYoshikazu Takada, M.D., Ph.D.
Yohsikazu Takada's laboratory is located in the Research III building on the Medical Center campus in Sacramento. * Satoshi Yamaji, Katsuaki Ieguchi – Postgraduate Researcher |
Publications: Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada YK, Takada Y. Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alpha Vbeta 3 and alpha 4beta 1 and induces proliferation of monocytic cells in an integrin-dependent manner. J Biol Chem. 2008 Jul 17. Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008 Jun 27;283(26):18066-75. Epub 2008 Apr 25. Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W. Inhibition of tissue factor signaling suppresses tumor growth. Blood. 2008 Jan 1;111(1):190-9. Epub 2007 Sep 27. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007;8(5):215. Review. Fleming FE, Graham KL, Taniguchi K, Takada Y, Coulson BS. Rotavirus-neutralizing antibodies inhibit virus binding to integrins alpha 2 beta 1 and alpha 4 beta 1. Arch Virol. 2007;152(6):1087-101. Epub 2007 Feb 23. Akakura N, Hoogland C, Takada YK, Saegusa J, Ye X, Liu FT, Cheung AT, Takada Y. The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth. Cancer Res. 2006 Oct 1;66(19):9691-7. Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. Nat Chem Biol. 2006 Jul;2(7):381-9. Epub 2006 Jun 11. Graham KL, Takada Y, Coulson BS. Rotavirus spike protein VP5* binds alpha2beta1 integrin on the cell surface and competes with virus for cell binding and infectivity. J Gen Virol. 2006 May;87(Pt 5):1275-83. Tarui T, Akakura N, Majumdar M, Andronicos N, Takagi J, Mazar AP, Bdeir K, Kuo A, Yarovoi SV, Cines DB, Takada Y. Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Thromb Haemost. 2006 Mar;95(3):524-34. Wu PL, Lee SC, Chuang CC, Mori S, Akakura N, Wu WG, Takada Y. Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family. J Biol Chem. 2006 Mar 24;281(12):7937-45. Epub 2006 Jan 10. Graham KL, Fleming FE, Halasz P, Hewish MJ, Nagesha HS, Holmes IH, Takada Y, Coulson BS. Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands. J Gen Virol. 2005 Dec;86(Pt 12):3397-408. Thodeti CK, Fröhlich C, Nielsen CK, Takada Y, Fässler R, Albrechtsen R, Wewer UM. ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. FEBS Lett. 2005 Oct 24;579(25):5589-95. Epub 2005 Sep 28. Schwarz M, Röttgen P, Takada Y, Le Gall F, Knackmuss S, Bassler N, Büttner C, Little M, Bode C, Peter K. Single-chain antibodies for the conformation-specific blockade of activated platelet integrin alphaIIbbeta3 designed by subtractive selection from naive human phage libraries. FASEB J. 2004 Nov;18(14):1704-6. Epub 2004 Sep 16. Mikawa M, Wang H, Guo L, Liu R, Marik J, Takada Y, Lam K, Lau D. Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells. Mol Cancer Ther. 2004 Oct;3(10):1329-34. Graham KL, Zeng W, Takada Y, Jackson DC, Coulson BS. Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences. J Virol. 2004 Nov;78(21):11786-97. Muramatsu H, Zou P, Suzuki H, Oda Y, Chen GY, Sakaguchi N, Sakuma S, Maeda N, Noda M, Takada Y, Muramatsu T. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. J Cell Sci. 2004 Oct 15;117(Pt 22):5405-15. Epub 2004 Oct 5. Takatsuki H, Komatsu S, Sano R, Takada Y, Tsuji T. Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3). Cancer Res. 2004 Sep 1;64(17):6065-70. Kamata, T., H. Ambo, W. Puzon-McLaughlin, K. K. Tieu, M. Handa, Y. Ikeda, and Y. Takada. 2004. Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit. Biochem J 378:1079. Tarui, T., N. Andronicos, R. P. Czekay, A. P. Mazar, K. Bdeir, G. C. Parry, A. Kuo, D. J. Loskutoff, D. B. Cines, and Y. Takada. 2003. Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. J Biol Chem 278:29863. Tarui, T., M. Majumdar, L. A. Miles, W. Ruf, and Y. Takada. 2002. Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin. J Biol Chem 277:33564. Eto, K., C. Huet, T. Tarui, S. Kupriyanov, H. Z. Liu, W. Puzon-McLaughlin, X. P. Zhang, D. Sheppard, E. Engvall, and Y. Takada. 2002. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem 277:17804. Kamata, T., K. K. Tieu, T. Tarui, W. Puzon-McLaughlin, N. Hogg, and Y. Takada. 2002. The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol 168:2296. Kamata, T., K. K. Tieu, A. Irie, T. A. Springer, and Y. Takada. 2001. Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model. J Biol Chem 276:44275. Tarui, T., L. A. Miles, and Y. Takada. 2001. Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells. J Biol Chem 276:39562. Tarui, T., A. P. Mazar, D. B. Cines, and Y. Takada. 2001. Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem 276:3983. Eto, K., W. Puzon-McLaughlin, D. Sheppard, A. Sehara-Fujisawa, X. P. Zhang, and Y. Takada. 2000. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem 275:34922. Yokoyama, K., H. P. Erickson, Y. Ikeda, and Y. Takada. 2000. Identification of amino acid sequences in fibrinogen gamma -chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3. J Biol Chem 275:16891. Puzon-McLaughlin, W., T. Kamata, and Y. Takada. 2000. Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3). J Biol Chem 275:7795. Zhang, X. P., W. Puzon-McLaughlin, A. Irie, N. Kovach, N. L. Prokopishyn, S. Laferte, K. Takeuchi, T. Tsuji, and Y. Takada. 1999. Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3. Biochemistry 38:14424. Kamata, T., R. C. Liddington, and Y. Takada. 1999. Interaction between collagen and the alpha(2) I-domain of integrin alpha(2)beta(1). Critical role of conserved residues in the metal ion-dependent adhesion site (MIDAS) region. J Biol Chem 274:32108. Yokoyama, K., X. P. Zhang, L. Medved, and Y. Takada. 1999. Specific binding of integrin alpha v beta 3 to the fibrinogen gamma and alpha E chain C-terminal domains. Biochemistry 38:5872. Meredith, J. E., Jr., W. B. Kiosses, Y. Takada, and M. A. Schwartz. 1999. Mutational analysis of cell cycle inhibition by integrin beta1C. J Biol Chem 274:8111. Zhang, X. P., T. Kamata, K. Yokoyama, W. Puzon-McLaughlin, and Y. Takada. 1998. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. J Biol Chem 273:7345. Takada, Y., T. Kamata, A. Irie, W. Puzon-McLaughlin, and X. P. Zhang. 1997. Structural basis of integrin-mediated signal transduction. Matrix Biol 16:143. Takagi, J., T. Kamata, J. Meredith, W. Puzon-McLaughlin, and Y. Takada. 1997. Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem 272:19794. Irie, A., T. Kamata, and Y. Takada. 1997. Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1. Proc Natl Acad Sci U S A 94:7198. Irie, A., T. Kamata, and Y. Takada. 1997. [Molecular mechanisms of integrin-ligand interaction]. Tanpakushitsu Kakusan Koso 42:1679. |
