5th
Annual California Tissue Engineering Meeting
University
of California, Davis
Davis,
California, USA
September
15-16, 2006
Program
Friday, September 15, 2006
9:00a - 5:00p Registration
& Poster Setup
10:00a 10:15a Welcome Address
Claire Pomeroy
Vice Chancellor and Dean, UC Davis School
of Medicine
10:15a
11:00a Zach
Hall
President, California
Institute for Regenerative Medicine.
11:00a
11:45a Irving Weissman
Stanford, Professor, School
of Medicine
Tissue Engineering &
Regenerative Medicine.
11:45a 1:00p Box
Lunch (provided) and Poster Viewing
Scientific Session 1: Stem Cell Technology
and Tissue Engineering
Moderator(s): Tony Ratcliffe, Synthasome Inc., President and CEO
Nathalie Gossett, the Alfred Mann
Institute at USC, Head of Marketing and
Business Development
1:00p-1: 30p Pancreatic
Endocrine Stem Cells: Fact and Fiction
Fred Levine, UC San Diego, Professor of Medicine
1:30p-1: 45p Student Presentation:
Development of an Imaging System for On-Line
Assessment of Human Embryonic Stem-Cell Derived Cardiomyocytes
Oscar Abilez et al. Stanford University, Bio-X Program, Department of Surgery, Department of Mechanical
Engineering, Department of Radiology and Medicine, Molecular Imaging Program
1:45p-2: 15p Stem Cells and Regenerative
Medicine: The Translational Road to
Therapies
Alice Tarantal, UC Davis, Professor, Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine
2:15p-2: 30p New to California Presentation:
Incomplete
Maturation of Embryonic Stem Cell-Derived Endothelial Cells
Kara E. McCloskey et al. Georgia Institute of Technology, Parker H.
Petit Institute for Bioengineering and Bioscience
Kara Just Moved to University of California, Merced, School of Engineering
2:30p-3: 00p Human Embryonic Stem Cells:
Advancing Technology for Therapeutic
Application
Jane Lebkowski, Geron, Senior Vice-President of Regenerative
Medicine
3:00p - 3:30p Break & Poster Session
Scientific Session 2: Cytokines and Cell
Signaling in Tissue Engineering
Moderator(s):
Ben Wu, UCLA,
Associate Professor, The Henry Samueli
School of Engineering and Applied Science
Mike Longaker, Stanford University, Deane P. and Louise
Mitchell Professor, Department of Surgery
3:30p -4:00p Strategies
for Organ Level Tissue Engineering
Geoffrey Gurtner, Stanford, Associate Professor, School of Medicine
4:00p -4:15p Student Presentation:
Global Gene Expression Profiling of Articular and Growth Plate
Cartilage
Shintaro Yamane et al., Department of
Orthopaedic Surgery, School of Medicine, University
of California, Davis
4:15p -4:40 p Hybrid
Biomaterials and Sustained Macromolecule Presentation
for
Bone Tissue Engineering
Kent Leach, UC Davis,
Department of Biomedical Engineering
4:40p -5:05p Collagen Targeted Growth
Factors: Role in Tissue Engineering
Bo Han, USC, Dept of Surgery and Biomedical Engineering,
Keck School of Medicine
5:05p -5:20p Post Doc. Presentation:
Regulatory Analysis of Bone
Morphogenetic Protein5
(bmp5) Expression in Fracture Healing
C. Ham et al., Department
of Surgery, Children's Surgical Research Lab
Stanford
School of Medicine
5:20p 5:50p Osteoblast
Interactions within Apatite Ionic Microenvironment
Ben Wu, UCLA, Associate
Professor, The Henry Samueli School of Engineering and Applied Science
6:00p - Reception and
Posters Session
Saturday, September
16, 2005
7:00a - 11:00a Registration
7:00a - 8:00a Breakfast (provided) & Poster
Session
Scientific Session 3: Biomaterial Engineering
Moderator(s): Scott Simon, UC Davis, Professor, and Department of
Biomedical
Engineering
Kevin Healy, UC Berkeley, Professor, Departments of Materials
Science and Engineering, and Bioengineering
8:00a-8: 30a Miniaturizing Cell Culture
Systems with Microfabrication.
Alexander Revzin, UC Davis,
Department of Biomedical Engineering
8:30a-8:45a Student Presentation:
Shaped, Scaffold-Free Cartilaginous Grafts for
Articular Cartilage Defects
Eun Hee Han
et al., University of California San Diego, Department of Bioengineering
8:45a-9:15a Protein-Polymer
Conjugates in Solution and on Surfaces for Applications in Medicine.
Heather Maynord, UCLA, Department of Chemistry & Biochemistry
9:15a-9:30a Student Presentation:
BMP-2 Release Rates Are Determined by
Surface Properties and Affect IN VITRO
AND IN VIVO Mineralization
Katie Cowan et al. UCLA, Department of Bioengineering
9:30a-10:005a Joints by Nature and by Design
Bob Sah, UC San Diego, Professor and Vice-Chair, Department of Bioengineering
10:00a - 10:30a Break
& Poster Session
Scientific Session 4: Tissue Engineering in
Industry
Moderator(s): AliceTarantal, UC Davis, Professor,
School of Medicine
Manuela Martins-Green, UC Riverside, Professor,
Department
of Cell Biology and Neuroscience
10:30a-11:00a Tissue
Engineering Products: Successes, Challenges, Perceptions
Art Khouri, Genzyme Vice President, Biomaterials Research
11.00a-11:30p Understanding the Potential of Adipose-Derived Stem Cells
for
Regenerative Medicine
John T.
Ransom, Cytori Therapeutics, Vice President of Research
11:30p-12:00p Tissue
Engineering and Stem Cell Therapy for Myocardial Repair
Randy Lee, UCSF, Associate Professor
of Medicine
12:00p-12:30p Sheet-Based
Tissue Engineering: From Bench Top to the First Clinical
Use of a
Completely Biological Tissue Engineered Blood Vessel
Nicholas L'Heureux, Cytograft, Chief Scientific Officer
12:30p Presentation of Awards & Closing
Ceremonies
Posters
Scientific
Session 1: Stem Cell Technology and Tissue Engineering
1. CHARLESTON BIOENGINEERED KIDNEY PROJECT.
Vladimir Mironov, Christopher Drake, Xuejun Wen. Bioprinting Research Center
Medical University of South
Carolina, Charleston, SC, USA
Scientific
Session 2: Cytokines and Cell Signaling in Tissue Engineering
2. COMBINATORIAL SIGNALING
MICROENVIRONMENTS FOR MANIPULATING CELL FATE.
Christopher J. Flaim1, Dayu Teng1, David A. Brafman1, Karl
Willert2, Sangeeta N. Bhatia3,
and Shu Chien1 1 Department of
Bioengineering, University of California San Diego 2 Department of Molecular
and Cellular Medicine, University of California San Diego 3 Division of Health
Sciences and Technology, Massachusetts Institute of Technology
3. BIOMINERALIZED SCAFFOLDS INHIBIT
OSTEOGENESIS IN THE PRESENCE OF SOLUBLE OSTEOGENIC SIGNALS.
Hillary
Davis and J. Kent Leach.
Department of Biomedical Engineering, University of California, Davis.
4. THE EFFECTS OF SYNTHETIC TRITERPENOIDS ON SZP SYNTHESIS IN ARTICULAR CHONDROCYTES.
Takahiro Niikura, M.D., Ph.D., Sang Yang Lee, M.D., A. Hari Reddi, Ph.D. Center for Tissue Regeneration and Repair,
Department of Orthopaedic Surgery, University of California, Davis
5.
REGULATION OF SZP SYNTHESIS BY TGF-BETA/BMP SUPERFAMILY MEMBERS IN ARTICULAR
CHONDROCYTES AND SYNOVIOCYTES.
Takahiro Niikura, M.D., Ph.D., A.
Hari Reddi, Ph.D. Center for Tissue Regeneration and Repair,
Department of Orthopaedic Surgery, University of California, Davis
6. THE INFLUENCE OF AGE ON THE EFFECTIVENESS
OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 IN PREVENTING ATROPHIC
NONUNION FORMATION.
Takahiro Niikura, M.D., Ph.D., David J. Hak,
M.D., M.B.A., Scott J. Hazelwood, Ph.D., A. Hari Reddi, Ph.D. Center for Tissue Regeneration and Repair,
Department of Orthopaedic Surgery, University of California, Davis
7. GLOBAL GENE PROFILING IN EXPERIMENTAL FRACTURE
NONUNIONS
REVEALS A DOWN REGULATION OF
BMP GENE EXPRESSION.
Takahiro Niikura, M.D., Ph.D.,
David J. Hak, M.D., M.B.A., A. Hari Reddi, Ph.D.
Center for Tissue Regeneration and Repair, Department of
Orthopaedic Surgery, University of California,
Davis
8. THE EFFECT OF RECOMBINANT HUMAN VASCULAR
ENDOTHELIAL GROWTH FACTOR ON PREVENTING ATROPHIC NONUNION FORMATION.
Takahiro Niikura, M.D., Ph.D., David J. Hak,
M.D., M.B.A., Scott J. Hazelwood, Ph.D., A. Hari Reddi, Ph.D. Center for Tissue
Regeneration and Repair, Department of Orthopaedic Surgery, University of
California, Davis
9. CELLULAR RESPONSE OF HDF AND MACROPHAGES
TO CHITOSAN BANDAGES.
Cassandra Cortez, Anna Lei, Megan Little, Ajay Shah,
Isabella Wulur, M.S. and Elizabeth Orwin, Ph.D. Depts. of Engineering and
Biology, Harvey Mudd College, Claremont, CA
10. CHEMOKINE ENVIRONMENT MAY IMPACT ENGRAFTMENT
POTENTIAL OF PRECURSOR POPULATIONS FOR LIVER TISSUE REGENERATION: NONHUMAN
PRIMATE STUDIES TO EXAMINE CELL TRAFFICKING AND COMPARTMENTALIZATION WITHIN
LIVER.
Ursula
Esser1, Kim Janatpour1, Yuyou
Duan2, Raj Ramsamooj1, Boris
Ruebner1 and Mark Zern2 1Dept. of Pathology, 2UC
Davis Transplant Program, UCDMC, Sacramento
11. CONDITIONED MEDIA FROM OSTEOCYTIC CELLS
EXPOSED TO HYPOXIC CONDITIONS INDUCES MIGRATION OF HUMAN MESENCHYMAL STEM
CELLS: ROLE OF OSTEOPONTIN AND CD44.
1Leah M. Forquer, 2Damian
C. Genetos, 1Clare E. Yellowley
1Department of Anatomy, Physiology & Cell
Biology, School of Veterinary Medicine, University of California, Davis, CA
2Department of Orthopaedic Surgery, School of Medicine, University of California, Davis
12. IMPACT
OF THE OXYGEN MICROENVIRONMENT ON THE OSTEOGENIC POTENTIAL OF ADIPOSE DERIVED STEM CELLS IN THREE DIMENSIONS.
Jiawei Hea,
Leah M. Forquerb, Clare E. Yellowleyb, J. Kent Leacha
aDept.
of Biomedical Engineering, University
of California, Davis,
California, 95616
bSchool
of Veterinary Medicine, University of
California, Davis,
California, 95616
13. VISUALIZATION
OF MCF10 AND MCF7 CELLS WITH HYBRID NSOM/AFM IN DIFFERENT IMAGING MODES.
Vahid Yazdanpanaha,
Yu Zhanga, Larry Pageb,
Nathaniel Portneyc, Mihri
Ozkanc, and Cengiz
Ozkanb
aDepartment of Mechanical Engineering, University of California Riverside, Riverside, CA 92521, USA
bDepartment of Biochemistry, University of Missouri, Columbia, MO 65201, USA
cDepartment of Electrical
Engineering, University of California Riverside ,Riverside, CA 92521, USA
14. IRON OXIDE NANOPARTICLES AGGREGATION STUDY IN BOTH NORMAL AND CANCER BREAST CELLS BY
AFM/NSOM HYBRID TECHNIQUE.
Yu Zhang, Vahid Yazdanpanah, and Cengiz Ozkan
Department of Mechanical Engineering, University of California Riverside, Riverside
15. A
POWERFUL SYSTEM TO ENGINEER TISSUES FOR ELUCIDATION OF CELL FUNCTION.
L. Zheng, C. Jau, M. Martins-Green,
Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521
Scientific
Session 3: Biomaterial Engineering
16. A MATERIALS-BASED APPROACH TO INDUCING ANGIOGENESIS USING BIOGLASS
45S.
Ann Leu and J. Kent Leach. Department of
Biomedical Engineering, University of California, Davis
17. GEOMETRY OF BONE SUBSTITUTES DEFINES CELL
POLARITY, MIGRATION AND PROLIFERATION.
J. Camilo Roldαn*+, Edwin Chang*, Lila Jazayeri*,
Geoffrey Gurtner*
*Laboratory for Microvascular Surgery and
Vascular Tissue Engineering, Stanford University,
*+Dep. Oral and Maxillofacial Surgery at University of Regensburg, Germany
18. NEUROHISTOPATHOLOGICAL
ANALYSIS OF SYNTHETIC BIOPOLYMERS IMPLANTED IN THE SPINAL CORD OF ADULT
DYSMYELINATED LES RATS
JACEK M.
KWIECIEN, DVM, MSc, PhD, Departments of Pathology and
Molecular Medicine and of Surgery, RONEN AVRAM, MD, Department of Surgery, ADAM
POWER, Department of Surgery, JOSEPH HUI, LEENA SHAHBAL, ANNE TSANG, Bachelor
of Health Sciences Program, McMaster University, Hamilton, Ontario, Canada, and
STEPHANE WOERLY, MD, PhD, Centre de Recherches sur les Macromolecules Vegetales,
Centre National de la Recherche Scientifique,
Grenoble, France.
19. CHARACTERIZING
MECHANICAL STRAINS IN A NOVEL THREE-DIMENSIONAL TISSUE CULTURE PLATFORM
Karen
A. Wei, John O. Gallagher, Jeffrey Jacot, Mark Mercola* and Andrew
D. McCulloch.
University
of California, San Diego, 9500 Gilman Drive, Mail Code #0412, La Jolla, CA
92093
*The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037
20. BUILDING OF A 3-D BLOOD VESSEL CULTURE
SYSTEM FOR CARDIOVASCULAR RESEARCH
H. Yuan, M. Yao and M. Martins-Green
Department of
Cell Biology and Neuroscience, University of California, Riverside
21. CONTROL OF CORNEAL FIBROBLAST PHENOTYPE
THROUGH CO-CULTURE WITH ENDOTHELIAL CELLS.
Jerrah Holth, Jamie Shoffeitt, Marta Bechtel, and Elizabeth Orwin
Depts. of
Engineering and Biology, Harvey Mudd College, Claremont, CA
22. Evaluation of
Aligned Crosslinked Collagen Mats for Use as
Scaffolding Material for Engineering Corneal Tissue.
Lindsay S. Wray, Dr. Elizabeth J. Orwin, Harvey Mudd College, Departments
of Biology and Engineering
Scientific Session 4: Tissue Engineering in Industry
23.
SIMULATION OF MACRO SCALE DRUG DELIVERY IN HUMANS
Metin Ozen,
Ph.D. OZEN ENGINEERING, INC. ANSYS CHANNEL PARTNER
NASA AMES RESEARCH PARK
Late
Abstracts:
24. INSULIN AND INSULIN LIKE GROWTH FACTORS (IGF-1
AND II) AND ITS SUPPLEMENT REGULATE SUPERFICIAL ZONE PROTEIN (SZP) IN ARTICULAR
CARTILAGE SURFACE CHONDROCYTES.
Arash Calafi, Sophia Chiu, Grayson DuRaine,
Shintaro Yamane, and A. Hari Reddi
Lawrence Ellison Center for Tissue
Regeneration and Repair, UC Davis School of Medicine, Sacramento CA 95817
25. CELL
DELIVERY SYSTEM FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY: GENERATION OF
NEURAL CELLS FROM HUMAN BONE MARROW STEM CELLS IN VITRO
Nicole Esclamado, Justin Kim, Elizabeth Orwin, Isabella Wulur
Depts. of Engineering and Biology, Harvey Mudd College, Claremont, CA
26. CELL THERAPY FOR THE INTERVERTEBRAL DISC: THE
ABILITY OF ADIPOSE-DERIVED STEM AND REGENERATIVE CELLS TO REPAIR ACUTE DISC
INJURY
*Timothy A. Moseley,
Ph.D., Lee A. Patterson, MD, Tim Ganey,
PhD, Billy Hutton, DSc,
Joerg Meisel,
MD, PhD and *Marc H. Hedrick, M.D.
Cytori Therapeutics, San Diego, CA; Emory University and Atlanta Medical Center, Atlanta GA; Bergmannstrost-Klinik,
Halle, Germany
27. Functional
evaluation of tissue engineered articular cartilage by magnetic resonance
imaging
Corey P. Neu, Ph.D., Huma Arastu, B.S., Shane Curtiss, A.S., A. Hari Reddi, Ph.D.
Lawrence Ellison Center for Tissue Regeneration
and Repair, UC Davis School of Medicine, Sacramento CA 95817
