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Research in pediatric nephrology

Lavjay Butani, M.D.

Lavjay Butani conducts research in the development of normative data on the urinary calcium to creatinine ratio, especially in children of different ethnicities to determine the impact of the urinary calcium to creatinine ratio on bone mineral density and on the risk of nephrolithiasis in prospective studies. In addition he studies complications of immunosuppressive medications and the effect of hyperlipidemia on graft function in children with renal transplants.

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Keith Lau, M.D.

Dr. Keith Lau conducts research on the role of abnormally glycosylated IgA1 molecules in the pathogenesis and as a biomarker of IgA nephropathy and Henoch Schonlein Purpura nephritis. Currently, the only way to diagnose IgA nephropathy is to perform a renal biopsy, thus there is a need to identify a less invasive clinical tool to diagnose this common childhood disease. Dr. Lau is also working with Dr. Tom Depner to study the kinetics of various blood components during hemodialysis.

Sudesh Makker, M.D.

Sudesh Makker conducts research on immune-mediated glomerular diseases. He investigates the biochemical and molecular nature of autoantigens responsible for autoimmune glomerular diseases and studies the immunopathologic mechanisms involved in the genesis as well as immuno-specific treatment of these diseases.

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Alfonso Tramontano, Ph.D.

Alfonso Tramontano conducts research in unconventional antibody function and molecular mechanisms of autoimmune disease pathogenesis. He investigates the role of pathogenic or beneficial autoantibodies induced with recombinant or chemically modified antigens in animal models of autoimmune glomerulonephritis, diabetes and rheumatoid arthritis. His unifying theme is to study the mechanisms bridging innate and adaptive immune responses. A long-term goal of his work is the development of strategies for immunotherapy of chronic diseases of autoimmune origin.

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