Jan Nolta, Ph.D.

Professor
CRISP Building, Sacramento Campus
(916) 703-9300
e-mail

Recent/Current
Research Funding

National Institutes of Health

California Institute for Regenerative Medicine

Research Interests

Dr. Nolta is the Director of the Stem Cell Program at UC Davis School of Medicine, and directs the new Institute for Regenerative Cures. The UC Davis stem cell program has over 145 faculty members collaborating to work toward stem cell-related cures for a spectrum of diseases and injuries. The current research in Dr. Nolta’s laboratory is focused on developing therapies that will use mesenchymal stem cells (MSCs) to deliver factors for treating Huntington’s disease and other disorders and injuries. Her group focuses on “bench to the bedside” research, and she has been involved in numerous clinical trials of gene and cell therapy. She is scientific director of the new Good Manufacturing Practice clean room facility at UC Davis, where stem cells of different types are being isolated or expanded for clinical trials.

The basic research in the Nolta laboratory focuses on understanding the dynamics of stem cell migration and attraction to sites of injury. Following intravenous infusion, adult stem cells home to sites of tissue damage. Areas studied are cellular response to hypoxia and chemokines, cell motility, cell-to-cell interactions, and paracrine factors secreted by MSC at the site of injury.

For more information please visit the Nolta Lab homepate at: http://www.jannolta.com 

 

Representative Publications

2003  Wu G, Nolta JA, Starnes V, and Cramer D. Migration of mesenchymal stem cells to heart allografts during chronic rejection. Transplantation Mar 15; 75(5): 679-685.

2003  Schmidt M, Carbonaro D, Speckmann C, Bohnsack J, Nolta JA, Kohn D, von Kalle C. Clonality Analysis after retroviral–mediated gene transfer to cord blood CD34+ cells of an ADA-deficient SCID infant. Nature Medicine, Apr1; 9(4); 463-68.

2004  D Hess, T Meyerrose, L Wirthlin, M Creer, P Herrbrich, T Craft, Nolta J. Functional characterization of highly purified human stem cells isolated based on aldehyde dehydrogenase activity. Blood, Sept.104:1648-55.

2007  Meyerrose TE, DeUgarte DA, Hofling A, Herrbrich P, Sands MS, Hedrick MA, and Nolta JA. In vivo Distribution of Adipose-Derived Mesenchymal Stem Cells in Novel Xenotransplant Models. Stem Cells.; 25; 220-227.

2008  G Bauer, M Dao, S Case, P Herrbrich, J Arevalo, T Meyerrose, X Wang, S Csik, D Skelton, D B. Kohn, and J Nolta. In Vivo Biosafety Model to Assess Risk of Adverse Events from Retroviral and Lentiviral Vectors. Mol Ther. Jul;16(7):1308-15.

2008  T Meyerrose, M Roberts, K Ohlemiller, C Vogler, L Wirthlin, J Nolta, M Sands. Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplant model of human disease. Stem Cells.26:1713-22.

2008  Zhou P, Hohm S, Capoccia B, Link D, and Nolta JA. Immunodeficient mouse models to study human stem-cell mediated repair of tissue injury. Methods Mol Biol; 430:213-25.

2008  D. Hess, T. Craft, L. Wirthlin, W. Eades, M. Creer, M. Sands, J. Nolta. Widespread nonhematopoietic tissue distribution by transplanted human progenitor cells with high aldehyde dehydrogenase activity. Stem Cells. Mar;26(3):611-20.

2008  Rosová I, Dao MA, Capoccia BJ, Link DC, Hess DA, Nolta JA. Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells. Stem Cells. Aug;26(8):2173-82.

2008  D. Maxwell, J. Bonde, D. Hess, M. Creer, R. Lahey, D. Piwnica-Worms, and J. Nolta. Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human stem cells. Stem Cells. Feb;26(2):517-24.

2009  Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human stem cells with high aldehyde dehydrogenase activity. Blood 21 May, 113 ( 21): 5340-5351.

2010  C Sondergaard, D Hess, D Maxwell, C Weinheimer, I Rosová, M Creer, D Piwnica-Worms, A Kovacs, L Pedersen, and J Nolta. Human UCB Progenitors with High ALDH Activity Improve Vascular Density in Acute Myocardial Infarction. In press, Journal of Translational Medicine.

2010  I. Rosová, D. Link, and J. Nolta. Small Interfering RNA-Mediated Decreases in c-Met Levels Affect the Differentiation Potential of Human Mesenchymal Stem Cells and Reduce Their Capacity for Tissue Repair. In press, Tissue Engineering.

 

Recent Books, Invited Articles, and Chapters (Selected, 3 of 20)

Meyerrose TM, Herrbrich P, Wang X, Dao MA, Nolta JA. Pluripotent human stem cell analysis in immune deficient mice. The Pluripotential Hematopoietic Stem Cell, Eurekah Press, 2003.

Meyerrose TE, Herrbrich P, Hess DA, Nolta JA. Immune-deficient mouse models for analysis of human stem cells. Biotechniques. Dec;35 (6):1262-72, 2003.

Meyerrose T, Rosova I, Dao M, Bauer G, Nolta JA. Establishment and transduction of primary human mesenchymal stem cell monolayers. Chapter 2 in Genetic Engineering of Mesenchymal Stem Cells. Kluwer, pp 45-58. Nolta JA (Editor). Feb 2006.

 

Recent/Current Teaching

BIM 272, Biomedical Engineering Graduate Course

BIO 186A, Stem Cell Technology and Medical Appliations

BMB 290, Medical Applications of Stem Cell Technology

CLH 250, Integrating Medicine Into Basic Science

HON 493, Cancer as a Process Special Study Module

MCB/ECH 294, Current Progress in Biotechnology

271/272, Tissue Engineering Class

Hematopoiesis 101: Scholars of the California Institute for Regenerative Medicine

Human Stem Cell Sorting, UC Davis Biotechnology Program Short Course on Flow Cytometry Special Summer Session

Howard Hughes Medical Students Special Summer Session

UC Davis Biotechnology Program Short Course on Flow Cytometry Special Summer Session

Stem Cells 101, Stem Cells in the Study and Treatment of Neurodegenerative Diseases, UCD/CSUS Bridges CIRM Stem Cell Program

 

Teaching and Research Awards

• International Society of Hematology New Investigator Award, 1996
• Research Career and Development Award, CHLA Research Institute, 1996
• James Shannon Directors Award, NIH NIDDK, 1997
• Huntington's Deisease Society of America Distinguished Leadership Award, 2008
• Associate Editor, Stem Cells, February 2008 - present
• California State University, Sacramento Distinguished Service Award, 2009