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Department of Cell Biology and Human Anatomy

Department of Cell Biology and Human Anatomy

Neil Hunter, Ph.D.

Neil Hunter, Ph.D.

Associate Professor
347C Briggs Hall
Davis Campus
(530) 754-4401
e-mail

Recent/Current
Research Funding

National Institutes of Health

Graduate Group Affiliations

Biochemistry, Molecular, Cellular and
Developmental Biology

Genetics

Microbiology

Research Interests

Molecular, genetic and cytological approaches to understanding the mechanism and regulation of crossing-over between chromosomes with respect chromosome transmission and genome instability.

 

Representative Publications

2013  Reynolds, A., Qiao, H., Yang, Y., Chen, J., Biswas, K., Holloway, K., Baudat, F., de Massy, B., Wang. J., Höög, C., Cohen, P. and Hunter, N. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nature Genetics doi:10.1038/ng.2541.

2012  Biswas, K., Das, R., Eggington, J.M., Qiao, H., North, S.L., Stauffer, S., Burkett, S., Betty K. Martin, B.S., Southon, E, Sizemore, S.C., Pruss, D., Bowles, K.R., Roa, B.B., Hunter, N., Tessarollo, L., Wenstrup, R.J., Byrd, R.A. and Sharan, S.K. Functional evaluation of BRCA2 variants mapping to the PALB2 binding and C-terminal DNA binding domains using a mouse ES cell–based assay. Human Molecular Genetics 21, 3993-4006. PMCID: PMC3428152.

2012  Qiao H., Chen, J., Reynolds, A., Höög, C., Paddy, M. and Hunter, N. Interplay between centromeres, synaptonemal complex and homologous recombination during mammalian meiosis. PLoS Genetics 8, e1002790. PMCID: PMC3386176.

2012  Zakheryevich, K, Tang, S., Ma, Y. and Hunter, N. Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell 149, 334-47.

2011  Hunter, N. Double duty for Exo1 during meiotic recombination. Cell Cycle 10(16), 2607-2609.

2011  Hwang, Y-H. and Hunter, N. Mapping meiotic breaks: Spo11 oligonucleotides precisely mark the spots. Genome Biology 12, 111-114. doi:10.1186/gb-2011-12-4-111.

2010  Zakheryevich, K, Ma, Y., Tang, S., Hwang, Y-H., Boiteux, S. and Hunter, N. Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand-break resection and resolution of double-Holliday Junctions. Molecular Cell 40, 1001-1015.

2010  Lao, J.P. and Hunter, N. Trying to avoid your sister. PLoS Biology 8(10): e1000519.

2010  Bzymek, M., Thayer, N.H., Oh, S.D., Kleckner, N. and Hunter, N. Double-Holliday Junctions are Intermediates of DNA Break Repair. Nature 464, 937-941.

2009  Oh S.D., Jessop, L., Lao, J.P., Lichten, M.J. and Hunter, N.H. Stabilization and Electrophoretic Analysis of Meiotic Recombination Intermediates in Saccharomyces cerevisiae. In, Methods in Molecular Biology, Meiosis Methods and Protocols, Scott Keeney, ed. (Totowa, Humana Press).

2008  Oh S.D., Lao, J.P. and Hunter, N., RecQ Helicase, Sgs1, and XPF-Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules During Meiotic Recombination. Molecular Cell 31, 324-336.

2008  Hunter, N., Hop1 and the meiotic DNA-damage response. Cell 132, 731-732.

2008  Hunter, N., The RecQ DNA helicases: Jacks-of all-trades or master-tradesmen? Cell Research 18, 328-330.

2008  Lao, J.P, Oh, S.D., Shinohara, M., Shinohara, A. and Hunter, N., Rad52 promotes post-invasion steps of meiotic double-strand-break repair. Molecular Cell, 29, 517-524.

2008  Shinohara, M, Oh, S.D., Hunter, N. and Shinohara, A., Crossover assurance and crossover interference are distinctly regulated by the ZMM/SIC proteins during meiosis. Nature Genetics, 40, 299-309.

2007  Oh S.D., Lao, J.P., Hwang, P.Y-H., Taylor, A.F., Smith, G.R. and Hunter, N., Sgs1, a Bloom's helicase ortholog, prevents aberrant crossing-over by suppressing the formation of multichromatid joint molecules. Cell 130, 259-272.

2006  Hunter, N., Meiotic Recombination. In, Molecular Genetics of Recombination, Aguilera, A. and Rothstein, R. (Eds), Topics in Current Genetics, Springer-Verlag, Heidelberg.

2006  Cromie, G. A., Hyppa, R. W., Taylor, A. F., Zakharyevich, K., Hunter, N., and Smith, G. R., Single Holliday Junctions are intermediates of meiotic recombination. Cell 127, 1167-1178.

2006  Martini, E., Diaz, R.L., Hunter, N. and Keeney, S., Crossover homeostasis in yeast meiosis. Cell 126, 285-295.

2004  Hunter, N., Meiosis. In, the Encyclopedia of Biological Chemistry, Lennarz, W. and Lane, M. (Eds), Elsevier Press, San Diego. pp 610-616.

2004  Boerner, V.G., Kleckner, N. and Hunter, N., Crossover/noncrossover differentiation, synaptonemal complex formation and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117, 29-45.

2003  de los Santos, T., Hunter, N., Lee, C., Larkin, B., Loidl, J., and Hollingsworth, N.M., The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics, 164, 81-94.

2002  Blat, Y., Protacio, R., Hunter, N. and Kleckner, N., Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Cell, 111 791-802.

2001  Hunter, N. and Kleckner, N., The single-end invasion: an asymmetric intermediate at the double-strand-break to double-Holliday junction transition of meiotic recombination. Cell 106, 59-70.

 

Recent/Current Teaching

MCB 220L BMB/CDB graduate student rotation course

MIC 296, Advanced Concepts in DNA Metabolism

BIS 101, Genes and Gene Expression

MIC 191, Introduction to Research

 

Honors and Awards

  • Wellcome Trust - Prize Travelling Postdoctoral Fellowship, 1993-1996
  • Wellcome Trust - Prize PhD Studentship, 2003-2006
  • Damon Runyon Cancer Foundation -Scholar Award, 2004-2006
  • Concern Foundation - Young Investigator Award, 2005
  • March of Dimes - Basil O'Conner Award, 2006
  • France-Berkeley Fund Award, 2007
  • Howard Hughes Medical Institute - Early Career Scientist, 2009
  • University of California, Davis Mutant Mouse Regional Resource Center Award
  • UC Davis Chancellor’s Fellow, 2009-2014