Adjunct Professor Emeritus 4430 Tupper Hall Davis Campus (530) 752-7101 e-mail
Recent/Current Research Funding
National Institutes of Health
UC Davis Children’s Miracle Network
Our overall objective is to understand how the formation of differentiated trophoblast phenotypes is orchestrated in trophoblast progenitor cells.
Successful pregnancy outcome in human and non-human primates is largely dependent on the activity of different kinds of placental trophoblast cells, all of which are derived from the trophectoderm layer of the blastocyst. Invasive (extravillous) trophoblasts migrate into uterine tissue and penetrate superficial uterine blood vessel endothelium. Non-invasive (villous) cytotrophoblasts fuse and form syncytiotrophoblast which forms the outer layer of the villous placenta. Disruption of trophoblast differentiation and trophoblast invasion are implicated as a cause of preeclampsia and other disorders of pregnancy. We have found that the mucin, MUC1, is expressed by trophoblasts and are currently investigating its role in regulating trophoblast invasion.