Specialties
Clinical and Molecular Pharmacology
Director: Michael DeGregorio, Pharm.D.
Co-Director: Phil Mack, Ph.D.
The Pharmacokinetics facility provides the resources and experienced personnel to perform kinetic analyses for clinical and preclinical chemotherapeutic drug development studies. In addition to providing basic pharmacokinetic services, this facility is intended to encourage and facilitate all areas of cancer research, including basic and translational research, by providing a range of analytical services such as high-performance liquid chromatography (HPLC) and atomic absorption spectrophotometry (AA). This facility can, for example, provide the equipment and the personnel expertise for sample storage and preparation, analyses of chemotherapeutic drugs and related compounds, and interpretation of pharmacokinetic, pharmacodynamic, and mass spectral data. This facility will also provide consultation services for pharmacokinetic research project methods, study design, kinetic sampling schedules, protocol review, and will collaborate in manuscript preparation.
The Molecular Pharmacology section of this shared resource provides (1) molecular correlative studies of tissues from patients on clinical trials, (2) evaluation of biomarkers of response or resistance, and (3) molecular analysis of drug activity in vivo. The service offers assays for NCI-funded Clinical Investigators who do not have their own labs (i.e., CTEP Translational Research Fund (TRF) contracts). Services include specialized collection and processing of biological specimens (buccal cells, sputum, shed tumor DNA in plasma, etc.), specimen log-in anonymity, specialized assays (IHC, mutational analyses, polymorphisms, ELISAs, laser scanning cytometry (LSC), centrifugal elutriation, etc. with quality controls), data oversight and collating, and data files for statistical review. New specialized assays are incorporated as needed for correlative studies.
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