Our TeamJohn Voss, Ph.D.
Research interests
My research interests are in observing molecular switching in proteins, as well as protein folding and assembly. This work is carried out in large part through the use electron paramagnetic resonance (EPR — a.k.a. ESR) spectroscopy of site-directed spin labels. We use this approach to address problems in several biological systems, including those related to cardiovascular and neurodegenerative diseases.
Graduate groups
Laboratory personnel
Ph: (530) 752-3164, (530) 754-5708
msbudamagunta@ucdavis.edu
Jens Lagerstedt, Ph.D.
Ph: (530) 752-3164, (530) 754-5708
jolagerstedt@ucdavis.edu
Michael Saxton, Ph.D.
Ph: (530) 752-6163
misaxton@ucdavis.edu
Recent publications
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Gupta VN, Narayanaswami VA, Budamagunta MS, Yamamoto TN, Voss JC, Ryan RO.
Lipid induced extension of apolipoprotein E helix 4 correlates with low density lipoprotein receptor binding ability.
J Biol Chem. 2006 Nov 1; [Epub ahead of print]
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Hess JF, Budamagunta MS, Shipman RL, FitzGerald PG, Voss JC.
Characterization of the linker 2 region in human vimentin using site-directed spin labeling and electron paramagnetic resonance.
Biochemistry. 2006 Oct 3;45(39):11737-43.
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Martin DD, Budamagunta MS, Ryan RO, Voss JC, Oda MN.
Apolipoprotein A-I assumes a "looped belt" conformation on reconstituted high density lipoprotein.
J Biol Chem. 2006 Jul 21;281(29):20418-26. Epub 2006 May 11.
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Tetali SD, Budamagunta MS, Voss JC, Rutledge JC.
C-terminal interactions of apolipoprotein E4 respond to the postprandial state.
J Lipid Res. 2006 Jul;47(7):1358-65. Epub 2006 Apr 21.
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Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH.
Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms.
J Biol Chem. 2005 Oct 7;280(40):34288-95. Epub 2005 Aug 1.
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Lagerstedt JO, Reeve I, Voss JC, Persson BL.
Structure and function of the GTP binding protein Gtr1 and its role in phosphate transport in Saccharomyces cerevisiae.
Biochemistry. 2005 Jan 18;44(2):511-7.
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Lagerstedt JO, Voss JC, Wieslander A, Persson BL.
Structural modeling of dual-affinity purified Pho84 phosphate transporter.
FEBS Lett. 2004 Dec 17;578(3):262-8.
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Shao B, Bergt C, Fu X, Green P, Voss JC, Oda MN, Oram JF, Heinecke JW.
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.
J Biol Chem. 2005 Feb 18;280(7):5983-93. Epub 2004 Nov 30.
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Hess JF, Budamagunta MS, FitzGerald PG, Voss JC.
Characterization of structural changes in vimentin bearing an epidermolysis bullosa simplex-like mutation using site-directed spin labeling and electron paramagnetic resonance.
J Biol Chem. 2005 Jan 21;280(3):2141-6. Epub 2004 Nov 18.
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Hess JF, Budamagunta MS, Voss JC, FitzGerald PG.
Structural characterization of human vimentin rod 1 and the sequencing of assembly steps in intermediate filament formation in vitro using site-directed spin labeling and electron paramagnetic resonance.
J Biol Chem. 2004 Oct 22;279(43):44841-6. Epub 2004 Jul 1.
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Shafer AM, Kalai T, Bin Liu SQ, Hideg K, Voss JC.
Site-specific insertion of spin-labeled L-amino acids in Xenopus oocytes.
Biochemistry. 2004 Jul 6;43(26):8470-82.
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Shafer AM, Bennett VJ, Kim P, Voss JC.
Probing the binding pocket and endocytosis of a G protein-coupled receptor in live cells reported by a spin labeled substance P agonist.
J Biol Chem. 2003 Sep 5;278(36):34203-10. Epub 2003 Jun 23. Erratum in: J Biol Chem. 2004 Jan 23; 279(4):3120.
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Oda MN, Forte TM, Ryan RO, Voss JC.
The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger.
Nat Struct Biol. 2003 Jun;10(6):455-60.
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Hess JF, Voss JC, FitzGerald PG.
Real-time observation of coiled-coil domains and subunit assembly in intermediate filaments.
J Biol Chem. 2002 Sep 20;277(38):35516-22. Epub 2002 Jul 16.