Michael F. Seldin, M.D., Ph.D.

Professor and Rowe Chair

4453 Tupper Hall
Ph: (530) 754-6016
Fax: (530) 754-6015

mfseldin@ucdavis.edu

Michael Seldin is the Albert Holmes Rowe Chair of Human Genetics, Professor of Biochemistry and Molecular Medicine and Professor of Medicine at the UC Davis School of Medicine. His training includes an M.D., Ph.D. at Baylor College of Medicine and postdoctoral training in the Arthritis Branch at the National Institutes of Health. Current responsibilities include chair of the Rowe Program in Human Genetics and Molecular Medicine, group leader of Genetics Graduate Group Human Genetics Focus Group, director of UC Davis Physician Scientist Training Program and editor of Genes and Immunity (together with Grant Gallagher at University of Medicine & Dentistry of New Jersey).

• Ancestry linkage to human disease;
• Defining population substructure;
• Genetics of autoimmune disease
• Genetics of Type 2 diabetes; and
• Diabetic Nephropathy and Comparative Genomics.

The laboratory is working on the development and application of methods to define underlying genetic variation that is critical to the etiopathogenesis of common human diseases. These studies are centered on understanding the genetic variation that is linked to human ancestry and application of this information as a tool for positional cloning and clinical epidemiological studies. Specific efforts using and developing these methods are being directed towards systemic lupus erythematosus in African American populations and Type 2 diabetes and diabetic nephropathy in Mexican American populations. Other efforts in the laboratory are defining population substructure and its relevance to disease association. In addition, the laboratory is engaged in linkage and association studies for a variety of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis and primary billiary cirrhosis. Multiple national and international collaborations include the North American Rheumatoid Arthritis Consortium (NARAC), Family Investigation of Nephropathy in Diabetes (FIND), and those with Finland (Jaakko Tuomilehto), UCSF (Lindsey Criswell and John Wiencke), UPEN (Hongzhe Li), North Shore (Peter Gregersen), Cornell, UMIN (Tim Behrens), Harbor UCLA (Sharon Adler and Eli Ipp), Phoenix NIH (Bill Knowler and Rob Hanson) NIEHS (Glinda Cooper), Baylor College of Medicine (John Belmont), Ohio State (Rick Kittles), Guatemala (Gabriel Silva), Sweden/Mexico (Marta Alarcon), Johns Hopkins (Michelle Petri), Eric Gershwin (UC Davis), Spain (Pablo Villoslada), and Italy (Carlo Selma). Collaborations with biotechnology industry include Perlegen Sciences and Celera Diagnostics.

1. Tian C, Hinds DA, Shigeta R, Kittles R, Ballinger DG, Seldin MF.
   A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping.
   Am J Hum Genet. 2006 Oct;79(4):640-9. Epub 2006 Aug 15.
    
2. Yang N, Li H, Criswell LA, Gregersen PK, Alarcon-Riquelme ME, Kittles R, Shigeta R, Silva G, Patel PI, Belmont JW, Seldin MF.
   Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine.
   Hum Genet. 2005 Dec;118(3-4):382-92. Epub 2005 Sep 29.
    
3. Seldin MF, Shigeta R, Laiho K, Li H, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Kaarela K, Kauppi M, Alexander HC, Begovich AB, Tuomilehto J.
   Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
   Genes Immun. 2005 Dec;6(8):720-2.
    
4. Runstadler JA, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.
   Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families.
   Arthritis Rheum. 2005 Jan;52(1):247-56.
    
5. Zhang C, Chen K, Seldin MF, Li H.
   A hidden Markov modeling approach for admixture mapping based on case-control data.
   Genet Epidemiol. 2004 Nov;27(3):225-39.
    
6. Runstadler JA, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.
   HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.
   Genes Immun. 2004 Nov;5(7):562-71.
    
7. Seldin MF, Morii T, Collins-Schramm HE, Chima B, Kittles R, Criswell LA, Li H.
   Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.
   Genome Res. 2004 Jun;14(6):1076-84. Epub 2004 May 12.
    
8. Collins-Schramm HE, Chima B, Morii T, Wah K, Figueroa Y, Criswell LA, Hanson RL, Knowler WC, Silva G, Belmont JW, Seldin MF.
   Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians.
   Hum Genet. 2004 Feb;114(3):263-71. Epub 2003 Nov 20.
    
9. Runstadler JA, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.
   Analysis of MHC region genetics in Finnish patients with juvenile idiopathic arthritis: evidence for different locus-specific effects in polyarticular vs pauciarticular subsets and a shared DRB1 epitope.
   Genes Immun. 2003 Jul;4(5):326-35.
    
10. Collins-Schramm HE, Chima B, Operario DJ, Criswell LA, Seldin MF.
    Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population.
    Hum Genet. 2003 Aug;113(3):211-9. Epub 2003 Jun 3.