Michael F. Seldin, M.D., Ph.D.

Professor and Rowe Chair

4453 Tupper Hall
Ph: (530) 754-6016
Fax: (530) 754-6015

mfseldin@ucdavis.edu

Michael Seldin is the Albert Holmes Rowe Chair of Human Genetics, Professor of Biochemistry and Molecular Medicine and Professor of Medicine at the UC Davis School of Medicine. His training includes an M.D., Ph.D. at Baylor College of Medicine and postdoctoral training in the Arthritis Branch at the National Institutes of Health. Current responsibilities include chair of the Rowe Program in Human Genetics and Molecular Medicine, group leader of Genetics Graduate Group Human Genetics Focus Group, director of UC Davis Physician Scientist Training Program and editor of Genes and Immunity (together with Grant Gallagher at University of Medicine & Dentistry of New Jersey).

• Ancestry linkage to human disease;
• Defining population genetic substructure;
• Genetics of autoimmune disease
• Genetics of Type 2 diabetes; and
• Diabetic Nephropathy
• Comparative Genomics.
The laboratory is working on the development and application of methods to define underlying genetic variation that is critical to the etiopathogenesis of common human diseases. These studies are centered on understanding the genetic variation that is linked to human ancestry and application of this information as a tool for positional cloning and clinical epidemiological studies. Specific efforts using and developing these methods are being directed towards systemic lupus erythematosus in African American populations and Type 2 diabetes and diabetic nephropathy in Mexican American populations. Other efforts in the laboratory are defining population substructure and its relevance to disease association. In addition, the laboratory is engaged in association studies for a variety of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis and primary biliary cirrhosis. Multiple national and international collaborations include the North American Rheumatoid Arthritis Consortium (NARAC), Family Investigation of Nephropathy in Diabetes (FIND), and those with Finland (Jaakko Tuomilehto), UCSF (Lindsey Criswell and John Wiencke), UPEN (Hongzhe Li), North Shore (Peter Gregersen), Cornell, UMIN (Tim Behrens), Harbor UCLA (Sharon Adler and Eli Ipp), Phoenix NIH (Bill Knowler and Rob Hanson) NIEHS (Glinda Cooper), Baylor College of Medicine (John Belmont), Ohio State (Rick Kittles), Guatemala (Gabriel Silva), Sweden/Mexico (Marta Alarcon), Johns Hopkins (Michelle Petri), Eric Gershwin (UC Davis), Spain (Pablo Villoslada), and Italy (Carlo Selma). Collaborations with biotechnology industry include Celera Diagnostics.

Genetics
Comparative Pathology
Physiology

Roman Kosoy Ph.D. Postdoctoral Fellow
Chao Tian Graduate Student
Rami Nassir Graduate Student
Michael Ransom Database Manager/Programmer
Russell Shigeta, Laboratory Analyst

1. Tian C, Hinds DA, Shigeta R, Kittles R, Ballinger DG, Seldin MF.
A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping.
Am J Hum Genet. 2006 Oct;79(4):640-9. Epub 2006 Aug 15.
 
2. Yang N, Li H, Criswell LA, Gregersen PK, Alarcon-Riquelme ME, Kittles R, Shigeta R, Silva G, Patel PI, Belmont JW, Seldin MF.
Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine.
Hum Genet. 2005 Dec;118(3-4):382-92. Epub 2005 Sep 29.

3.  2006 Criswell LA, Sang KG, Miuls TR, Cerhan JR, Merlino LA, Lum RF, Pfeifffer KA Woehl B and Seldin MF. Smoking interacts with genetic risk factors in the development of rheumatoid arthritis amoung older Caucasian women. Annals of the Rheumatic Diseases 65:1163-1167.
 
4.  2006 Seldin MF, Shigeta R, Villoslada P, Selmi C, Tuomilehto J, Silva G, Belmont JW,  Klareskog L, and Gregersen P. European Population Substructure: Clustering of Northern and Southern Populations.  PloS Genetics 2:1339-13512.

5.  2007 Tian C, Hinds DA, Shigeta R, Adler SG, Lee A, Pahl MV, Silva G, Belmont JW, Hanson RL, Knowler WC, Gregersen PK, Ballinger DG, and Seldin MF.  A Genome-Wide SNP panel for Mexican American Admixture Mapping. Am J Hum Genet, 80:1014-1023.

6.  2007 Seldin MF.  Admixture mapping as a tool in gene discovery, Current Opinions in Genetics and Development. Curr Opin Genet Dev. 17:177-181.

7.  2007 Remmers EF., Plenge, RM, Lee AT, Graham RP, Hom G, Behrens TW, de Bakker PIW, Le JM, Lee H-S, Franak Batliwalla, Ph.D., Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos, CI, Criswell LA, Seldin MF, Kastner DL, and Gregersen PK.  STAT4 and Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus.  N Engl J Med 357:977-986.

8.  2007 Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran AI, R.L. L, Davies BS, Li W, Tan AKS, Bonnard C, Ong RTH, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK (2007) Genome-Wide Search Identifies TRAF1-C5 as Rheumatoid Arthritis Risk Locus. N Engl J Med 357:1199-1209.

9.  2007 Criswell LA and Seldin MF.  Admixed Populations and Autoimmunity. Arthritis Rheum 58:335-337.

10. 2008 Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, Selmi C, Klareskog L, Pulver AE, Qi L, Gregersen PK, and Seldin MF.  Analysis and Application of European Genetic Substructure Using 300K SNP Information.  PLoS Genet 4: e4.

11. 2008 Seldin MF, and Price AL (2008) Application of Ancestry Informative Markers to Association Studies in European Americans PLoS Genet 4: e5.

12. 2008 Hom, G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA,   Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AJ, Tian C,   Gunnarsson I, Bengtsson AA, Rantapaa-Dahlqvist S, Petri M, Manzi S, Seldin MF,   Ronnblom L, Syvanen AC, Criswell LA,  Gregersen PK , and Behrens TW.  Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358:900-909.
 
13. 2008 Seldin MF , Qi L ,  Scherbarth HR, Tian C, Ransom M, Silva G, Belmont JW,  Gamron S,  Allievi A, Palatnik SA, Saurit V, Paira S, Graf C, Guillerón C, Catoggio LJ, Prigione C, Berbotto GA, García MA, Perandones CE, Truedsson L, Abderrahim H, Battagliotti CG, Pons-Estel BA, and  Alarcon-Riquelme ME. Amerindian Ancestry in Argentina is Associated with Increased Risk for Systemic Lupus Erythematosus.  Genes Immun, In Press.

14. 2008 Kosoy R, Nassir R, Tian C, White PA, Butler LM, Silva G, Kittles R, Alarcon-Riquelme ME, Gregersen PK, Belmont JW, De La Vega FM, and Seldin MF. Ancestry Informative Marker Sets for Determining Continental Origin and Admixture Proportions in Common Populations in America. Human Mutation, In Press.