Kermit L Carraway III, Ph.D.

Associate Professor

Basic Sciences, Research III Bldg., Rm. 1400
UC Davis Cancer Center
4645 2nd Avenue,
Ph: (916) 734-3114
Fax: (916) 734-0190
klcarraway@ucdavis.edu

Cornell University, Biochemistry, Ph.D., 1992 - 1995
Harvard Medical School, Cell Signaling, Postdoctoral Fellow, 1993 - 1996

Dr. Carraway's research interests include the roles of mammalian growth factors and receptors in normal development and tumor progression, Drosophila growth factors and receptors, intracellular signal transduction pathways, and receptor trafficking and degradation.

1. Carraway KL 3rd, Sweeney C.
   Co-opted integrin signaling in ErbB2-induced mammary tumor progression.
   Cancer Cell. 2006 Aug;10(2):93-5. Review.
   
2. Sweeney C, Miller JK, Shattuck DL, Carraway KL 3rd.
   ErbB receptor negative regulatory mechanisms: implications in cancer.
   J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):89-99.
   
3. Funes M, Miller JK, Lai C, Carraway KL 3rd, Sweeney C.
   The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.
   J Biol Chem. 2006 Jul 14;281(28):19310-9. Epub 2006 May 11.
   
4. Laederich MB, Funes-Duran M, Yen L, Ingalla E, Wu X, Carraway KL 3rd, Sweeney C.
   The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosin kinases.
   J Biol Chem. 2004 Nov 5;279(45):47050-6. Epub 2004 Sep 1.
   
5. Wu X, Yen L, Irwin L, Sweeney C, Carraway KL 3rd.
   Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
   Mol Cell Biol. 2004 Sep;24(17):7748-57.
   
   
6. Sweeney C, Carraway KL 3rd.
   Negative regulation of ErbB family receptor tyrosine kinases.
   Br J Cancer. 2004 Jan 26;90(2):289-93. Review.
   
7. Carraway KL 3rd, Sweeney C.
   EGF receptor activation by heterologous mechanisms.
   Cancer Cell. 2002 Jun;1(5):405-6.
   
8. Ravid T, Sweeney C, Gee P, Carraway KL 3rd, Goldkorn T.
   Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation.
   J Biol Chem. 2002 Aug 23;277(34):31214-9. Epub 2002 Jun 12.